Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

Abdülkadir Şahan; Abdülkerim Yılmaz; Türker Taşlıyurt; Sibel Doruk; Handan İnönü Köseoğlu; Hakan Şıvgın; Mustafa Sağcan

doi:10.7197/cmj.v36i2.1008002087

EN TR

Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

Abstract

Abstract

Aim. Chronic obstructive pulmonary disease (COPD) is a chronic, progressive, inflammatory disease. Oxidative stress and airway inflammation are its main pathophysiologic components. In this study, our aim was to investigate the effect of an angiotensin receptor blocker (ARB) telmisartan which also exerts antiinflammatory effects on inflammation and oxidative stress in COPD. Method. The study group consisted of 50 stable COPD patients including 25 telmisartan users. Exhaled breath condensate (EBC) samples of the cases were collected using an EBC collecting device (Ecoscreen, Jaeger, Germany). EBC samples were analyzed and 8-isoprostane levels were measured using an enzyme immunoassay method (Cayman Chemical Co. Michigan, USA). Results. Any intergroup difference as for mean age, distribution of gender and smoking were not found. In telmisartan users, and nonusers mean 8-isoprostane levels were 33.98 and 35.91 pg/mL, respectively with a statistically significant intergroup difference (p<0.001) Conclusion. We think that ARBs decrease oxidative stress and inflammation, and thus exert favourable effects on the pathophysiology and progression of COPD.

Keywords: Chronic obstructive pulmonary disease, oxidative stress, 8-isoprostane, angiotensin receptor blocker, telmisartan

Özet

Amaç. Kronik obstrüktif akciğer hastalığı (KOAH) kronik, ilerleyici, inflamatuar bir hastalıktır. Oksidatif stres ve havayolu inflamasyonu hastalığın ana patofizyolojik etkenleridir. Bu çalışmada bir anjiyotensin reseptör blokeri (ARB) olan telmisartan’ın KOAH’daki antiinflamatuar etkisini araştırmayı amaçladık. Yöntem. Çalışmaya 25’i telmisartan kullanan 50 KOAH hastası alındı. Hastaların yoğunlaştırılmış soluk havası (EBC) örnekleri EBC toplama cihazı kullanılarak toplandı (Ecoscreen, Jaeger, Germany). EBC örnekleri analiz edildi ve enzim immunoassay metodu (Cayman Chemical Co. Michigan, USA) kullanılarak 8-izoprostan düzeyleri ölçüldü. Bulgular. Her iki grup arasında ortalama yaş, cinsiyet ve sigara kullanımı açısından fark yoktu. Telmisartan kullanan ve kullanmayan grupta 8-izoprostan düzeyleri sırasıyla 33,98 ve 35,91 pg/mL olarak ölçüldü, iki grup arasındaki fark istatistiksel olarak anlamlı bulundu (p<0,001). Sonuç. ARB’lerin oksidatif stres ve inflamasyonu azaltarak hastalığın patofizyolojisi ve ilerleyişine olumlu etkileri olabilir.

Anahtar sözcükler: Kronik obstrüktif akciğer hastalığı, oksidatif stres, 8-izoprostan, anjiyotensin reseptör blokeri, telmisartan

Keywords

Chronic obstructive pulmonary disease, oxidative stress, 8-isoprostane, angiotensin receptor blocker, telmisartan

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English

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Authors

Abdülkadir Şahan

Abdülkerim Yılmaz

Türker Taşlıyurt

Sibel Doruk

Handan İnönü Köseoğlu

Hakan Şıvgın

Mustafa Sağcan

Publication Date

June 27, 2014

Submission Date

April 2, 2013

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Year 2014 Volume: 36 Number: 2

DOI

https://doi.org/10.7197/cmj.v36i2.1008002087

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https://izlik.org/JA34WN45LD

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RIS / Bibtex

AMA

1.Şahan A, Yılmaz A, Taşlıyurt T, et al. Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate. CMJ. 2014;36(2):178-183. doi:10.7197/cmj.v36i2.1008002087

Cited By

Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers

Critical Care Medicine

https://doi.org/10.1097/CCM.0000000000003475

Antiinflammatory effect of telmisartan on chronic obstructive pulmonary disease: 8-isoprostane concentration in exhaled breath condensate

Abstract

Keywords

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Risk of Sepsis and Mortality Among Patients With Chronic Obstructive Pulmonary Disease Treated With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers