Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Mustafa Ergül; Adamu Bekele; Hatice Terzi; Ahmet Altun

doi:10.7197/cmj.vi.578764

EN TR

Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Abstract

Cancer is the main cause of death and morbidity worldwide. Among females, breast cancer is the most commonly diagnosed and the leading cause of cancer-related death. Despite an improvement in the treatment of cancer in the latest years, metastatic breast cancer treatment success is not at a desirable level. Plants have huge potential to endow us with noble drugs and current drugs of plant origin are important part of cancer chemotherapy. The aim of this study was to evaluate the antiproliferative activity of wheat germ oil in MCF-7 breast cancer cell line. Antiproliferative activity and apoptotic effect of wheat germ oil were examined using the XTT and flow cytometry assay, respectively. According to the XTT results, at concentrations greater than 0.5 mg/mL, wheat germ oil displayed significant antiproliferative activity in MCF-7 cells in a dose-dependent manner. The Annexin V binding assay results also demonstrated that the IC₅₀ concentration of wheat germ oil increased early and late apoptotic populations (p < 0.05). Though further studies are required to specifically identify compounds involved in the anticancer activity of wheat germ oil, our findings demonstrate that wheat germ oil inhibits proliferation of MCF-7 cells and its action is dose-dependent.

Keywords

Cancer,apoptosis,MCF-7

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Mustafa Ergül ^*
0000-0003-4303-2996
Türkiye

Adamu Bekele
Ethiopia

Hatice Terzi
Türkiye

Ahmet Altun
0000-0003-2056-8683
Türkiye

Publication Date

September 30, 2019

Submission Date

June 18, 2019

Acceptance Date

September 30, 2019

Published in Issue

Year 2019 Volume: 41 Number: 3

DOI

https://doi.org/10.7197/cmj.vi.578764

IZ

https://izlik.org/JA37FT97ET

Cite

RIS / Bibtex

AMA

1.Ergül M, Bekele A, Terzi H, Altun A. Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines. CMJ. 2019;41(3):500-505. doi:10.7197/cmj.vi.578764

Cited By

Dose-dependent effects of wheat germ oil and vitamin E on apoptosis and gene expression in breast and cervical cancer cell lines with single-cell RNA-seq profiling

Scientific Reports

https://doi.org/10.1038/s41598-025-25408-3

Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines

Abstract

Keywords

Öz

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Dose-dependent effects of wheat germ oil and vitamin E on apoptosis and gene expression in breast and cervical cancer cell lines with single-cell RNA-seq profiling