New generation graphene-based dendritic phthalocyanine: Potential usage for biomedical applications
Abstract
Objective: It is aimed to produce new graphene-based materials with potential used in biomedical applications.
Method: The new GO-ZnPc hybrid was obtained by self-assembly method. Sonication was performed in the formation of hybrid. UV-Vis, emission spectra and scanning electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation.
Results: The GO solutions of different concentrations (0.0005 µg / mL; 0.005 µg / mL; 0.05 µg / mL; 0.4 µg / mL; 0.7 µg / mL; 1 µg / mL) prepared by sonication were added to 10 µg / mL ZnPc solution separately and sonicated again. UV-Vis, emission spectra and scanning electron microscopy (SEM) were used to characterize ZnPc-GO hybrid formation. All measurements showed that intermolecular interactions occurred after mixing the two components together, and the resulting hybrid was stable.
Conclusions: In this study, the new ZnPc-GO hybrid prepared and characterized. ZnPc and GO derivative was observed to well-coordinated. The obtained hybrid system was observed to have very interesting spectroscopic properties. It was observed that the GO-based ZnPc hybrid gave an absorption peak at 716 nm in the UV-Vis spectrum. The redshift observed with the ZnPc-GO hybrid formation in the UV spectra indicates that this material has the potential to be used in many biomedical applications, especially in tissue engineering and photodynamic therapy.
Keywords
References
- [1] Yang Y, Asiri A M, Tang Z, Du D, Lin Y. Graphene based materials for biomedical applications. Mater Today 2013; 16: 365-373.
- [2] Nanda S S, Papaefthymiou G C, Yi D K. Functionalization of Graphene Oxide and its Biomedical Applications. Crit Rev Solid State 2015; 40: 291-315.
- [3] Huang P, Xu C, Lin J, Wang C, Wang X, Zhang C, Zhou X, Guo S, Cui D. Folic Acid-conjugated Graphene Oxide loaded with Photosensitizers for Targeting Photodynamic Therapy. Theranostics 2011; 1: 240-250.
- [4] Li Y, Dong H, Li Y, Shi D. Graphene-based nanovehicles for photodynamic medical therapy. Int J Nanomed 2015; 10: 2451-2459.
- [5] Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J. Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system. J Photoch Photobio B 2014; 135: 7-16.
- [6] Shen H, Zhang L, Liu M, Zhang Z. Biomedical Applications of Graphene. Theranostics 2012; 2: 283-294.
- [7] Youssef Z, Vanderesse R, Colombeau L, Baros F, Roques‑Carmes T, Frochot C, Wahab H, Toufaily J, Hamieh T, Acherar S, Gazzali A M. The application of titanium dioxide, zinc oxide, fullerene, and graphene nanoparticles in photodynamic therapy. Cancer Nano 2017; 8: 1-62.
- [8] Tabisha T A, Zhanga S, Winyard P G. Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species. Redox Biol 2018; 15: 34-40.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Authors
Ebru Yabaş
*
0000-0001-7163-3057
Türkiye
Publication Date
September 30, 2019
Submission Date
September 23, 2019
Acceptance Date
September 30, 2019
Published in Issue
Year 2019 Volume: 41 Number: 3