Comparison of CYP1A1 and CYP1B1 expressions in tissue biopsies obtained from with diagnosis invasive breast lobular carcinoma
Abstract
Objective: Expression of CYPs may provoke tumor development targeting activation of procarcinogens or increase in development and proliferation of breast tumor cells. Moreover, it affects the etiology of breast cancer and they may also change response to treatment. So, we aimed to compare the protein expression of CYP1A1 and CYP1B1, which are the most commonly expressed in breast cancer, which is so important.
Method: Breast biopsy specimens from at least 14 invasive breast lobular carcinoma were used and they obtained from Adiyaman University Pathology Department. The protein expression of CYP1A1, CYP1B1 were determined by immunohistochemically method. Staining intensity was graded as 0 if no staining was observed, +1 if weak staining was present, +2 if moderate staining was observed, and +3 if strong staining was present.
Results: Results were assessment using the total number of participants. When pathologic and histological glands are considered, for right breast, as +3 staining CYP1A1 and CYP1B1 protein expressions were found to be 83.33 % and 16.67 % respectively. In +2 staining CYP1A1 protein expressions was found to be 16.67 %, but CYPB1 not expressed. For left breast, CYP1A1 protein was strongly stained by 50 %. In account of moderate staining. In terms of moderate staining, both CYP1A1 and CYP1B1 proteins were expressed in 33.33 % percent. Besides, weak staining results to be found. CYP1A1 and CYP1B1 were found to be 16.67 % and 33.33 %, respectively. No statistically significant difference was found between CYP1A1 and CYP1B1 (P>0.05).
Conclusions: CYP1A1 was expressed in all cases, whereas CYP1B1 was expressed less or not at all. These results indicate that CYP1A1 can an important marker in breast cancer cases.
Keywords
Thanks
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Authors
İşıl Yıldırım
*
0000-0002-3027-6054
Türkiye
Bilge Aydın Türk
Türkiye
Serpil Oğuztüzün
Türkiye
Pınar Kaygın
Türkiye
Publication Date
December 31, 2019
Submission Date
September 25, 2019
Acceptance Date
January 2, 2020
Published in Issue
Year 2019 Volume: 41 Number: 4