Assessment of rabex-5 level of thyroid nodules with benign and malignant characteristics in aspiration cytology
Abstract
Objective: The aim of the present study was to determine the Rabex-5 level in the plasma of patients who were found to have benign and malignant cytology as a result of fine-needle aspiration biopsy implemented on thyroid nodules and to determine whether there was a difference between benign and malignant.
Method: The cytology of 117 benign and 26 malignant thyroid nodules was evaluated as the study material.
Results: It was determined that the nodule diameter had no effect on benign and malignant cytology (p 0.998). There was no significant difference found between age and benign and malignant cytology results (p 0.591). There was no difference between female and male genders in terms of Rabex-5 level (p 0.654).
Conclusions: In conclusion, it was found that there was no difference in plasma RABEX-5 levels of patients with benign and malignant thyroid nodule cytology. However, it is thought that further studies to evaluate the expression of Rabex-5 in cancerous tissues of patients with thyroid malignancies will provide a scientific contribution
Keywords
References
- Vanderpump MP The Epidemiology of Thyroid Disease. Br Med Bull (2011).99:39-51.
- Ze Rial M, Mcbride H. Rab Proteins as Membrane Organizers. Nat Rev Mol Cell Biol (2001). 2: 107-117.
- Erdoğan MF, Kamel N, Aras D, Akdoğan A, Başkal N, Erdoğan G. Value of Re-aspira Benign Nodular Thyroid Disease. Thyroid (1998).8:1087-90.
- Bernards A, Settlema NJ. GAP Control: Regulating the Regulators of Small GTPases. Trends Cell Biol (2004). 14: 377-385.
- Zhang JS, Yang LQ, Du Br, Gao H. Higher RABEX-5 mRNA Predicts Unfavourable Survival in Patients with Colorectal Cancer. Eur Rev Med Pharmacol Sci. (2017). 21(10):2372-2376.
- Kang l, Hao X, Tang Y, Wei X, Gong Y. RABEX-5 Overexpression in Gastric Cancer is Correlated with Elevated MMP-9 level. Am J Transl Res (2006). 8: 2365-2374.
- Zhang F, Jia Y, Kong F, Hu G, Cai Q, Xu T. Elevated RABEX-5 Expression Predicts Poor Prognosis in Non-Small-Cell Lung Cancer. Am J Cancer Res (20015). 5: 2849-2855.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
December 31, 2019
Submission Date
December 23, 2019
Acceptance Date
December 31, 2019
Published in Issue
Year 2019 Volume: 41 Number: 4