Research Article

The relationship between free thyroid hormone index and thyrotoxicosis in pregnancy

Volume: 42 Number: 1 May 20, 2020
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The relationship between free thyroid hormone index and thyrotoxicosis in pregnancy

Abstract

Objective: The aim of this study was to evaluate free thyroid hormone index (FTHI) (FT3 index/ FT4 index) as a parameter to use in differential diagnosis of gestational Graves’ disease (GGD) and gestational transient thyrotoxicosis (GTT). GGD and GTT are the most common causes of thyrotoxicosis in early pregnancy and differential diagnosis is important since they are treated differently. 
Method: Women who applied to our clinic with thyrotoxicosis were evaluated and 51 pregnant women were recruited to the study. Among the 51 women, 36 had GTT, 15 had GGD. The age, gestational age, thyroid stimulating hormone (TSH) levels, and FTHI (FT3 index / FT4 index) of all patients were recorded and compared. FT3/FT3 upper limit of normal (ULN) is referred as FT3 index. FT4 index is also referred as FT4/FT4 ULN. All diagnosis of GGD and GTT was confirmed with TRAb assays.
Results: The mean values of FT3, FT3 index, FTHI of the GGD group were found to be statistically significantly higher compared to GTT group (p: 0.002, p: 0.001, 0.001; respectively). No statistically significant difference was found between groups in terms of age, gestational age, FT4, FT4 index and TSH (p:0.999, p:0.730, p:0.620, p:0.570, p:0.291; respectively) FTHI values were above 1 in all patients with GGD while it was below 1 in GTT group. 
Conclusions: The FTHI values above 1 may be used as a practical, cheap parameter for differential diagnosis between GGD and GTT.

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References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Publication Date

May 20, 2020

Submission Date

May 6, 2020

Acceptance Date

May 13, 2020

Published in Issue

Year 2020 Volume: 42 Number: 1

DOI

https://doi.org/10.7197/cmj.vi.732979

IZ

https://izlik.org/JA24FH97JZ

Cite

RIS / Bibtex
AMA
1.Acıbucu F, Uysal G, Bankir M. The relationship between free thyroid hormone index and thyrotoxicosis in pregnancy. CMJ. 2020;42(1):94-99. doi:10.7197/cmj.vi.732979

Cited By

Advances in the differential diagnosis of transient hyperthyroidism in pregnancy and Graves’ disease

Archives of Gynecology and Obstetrics

https://doi.org/10.1007/s00404-022-06774-z