The predictive value of mean platelet volume, neutrophil lymphocyte ratio and platelet lymphocyte ratio in acute middle cerebral artery infarction patients

Hamit Çelik; Mesut Erbas

doi:10.7197/cmj.vi.746648

TR EN

Akut orta serebral arter enfarkt hastalarında ile ortalama trombosit hacmi, nötrofil lenfosit oranı ve trombosit lenfosit oranının prediktif değeri

Öz

Amaç: Tıkayıcı beyin damar hastalıklarında ortalama trombosit hacminin arttığı, lenfosit ve nötrofilerin iskemik hasarı artırdığı bilinmektedir. Çalışmamızda akut orta serebral dal enfarkı olan hastalarda ortalama trombosit hacmi, nötrofil lenfosit oranı ve trombosit lenfosit oranının prediktif değerini belirlemeyi amaçladık.

Yöntem: Nisan 2017–Eylül 2019 tarihleri arasında Çanakkale Onsekiz Mart Anestezi ve Reanimasyon yoğun bakımda takip edilen, daha önce iskemik inme geçirmemiş akut orta serebral arter dal tıkanıklığı olan 50 hastanın dosyası geriye dönük olarak incelendi. Hasta grubu ulusal inme sağlık ölçeği skalası (NIHSS) ve Modifiye rankin skoru (mRS) kullanılarak değerlendirildi. İnmenin ilk saatindeki nötrofil ve trombosit sayısının lenfosit sayısına (NLO ve TLO oranı) oranının ve OTH (ortalama trombosit hacmi) düzeylerini Benzer yaş ve cinsiyette kontrol grubu ile karşılaştırdık.

Bulgular: Çalışmamıza akut orta serebral arter dal iskemisi olan 28’i kadın (%56) olmak üzere 50 hasta alındı. Kontrol grubu ise yaşı ve cinsiyetiyle uyumlu 24’ü (%48) kadın 50 sağlıklı kişi alındı. Hastaların ortalama NIHSS skoru 11.4±2.6 ve ortalama mRS skoru 2.5±1.5 idi.

Sonuç: Tıkayıcı beyin damar hastalıklarında hematolojik parametrelerin inmenin şiddeti ve prognozuyla ilişkisini inceleyen birçok çalışma vardır. Akut orta serebral arter dal infarktı geçiren hastalarla yaptığımız bu çalışmada inmenin ilk saatinde bakılan NLO, TLO, OTH düzeyini kontrol grubu ile kıyaslandığında istatiksel olarak anlamlı yüksek bulundu. Hematolojik parametrelerin iskemik inmede bir biyobelirteç olarak kullanılması için çok merkezli daha geniş katılımlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Orta serebral arter dal enfarktı, ortalama trombosit hacmi, nötrofil, lenfosit

The predictive value of mean platelet volume, neutrophil lymphocyte ratio and platelet lymphocyte ratio in acute middle cerebral artery infarction patients

Abstract

Objective: The aim of this study was to determine the predictive value of mean platelet volume (MPV), neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) in patients with acute middle cerebral artery (MCA)branch infarction.

Method: This examination was performed on the files of 50 patients followed up at the Anesthesia and Reanimation ICU of Onsekiz Mart University Hospital between April 2017 and September 2019 for acute occlusion in the MCA branch, with no previous history of an ischemic stroke. These patients were assessed with the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Score (mRS). The ratios of the neutrophil and platelet countsto the lymphocyte count (NLR and PLR ratios) within the first hour of the stroke and MPV were compared to a control group.

Results: The study included 50 patients with the acute ischemia of the MCA branch, of which 28 (56%) were female. The control group consisted of 50 healthy people, and 24 (48%) of these were female. The mean NIHSS score of the patients was 11.4 ± 2.6, and their mean mRS was 2.5 ± 1.5.

Conclusions: In our study with patients who had acute middle cerebral artery infarction, we found that the NLR, PLR, and MPV levels within the first hour of stroke were higher in the patient group in comparison to the control group ona statistically significant level. However, multicenter studies with larger subject groups are needed for the use of hematological parameters as biomarkers in an ischemic stroke

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hamit Çelik ^*
0000-0002-8654-2518
Türkiye

Mesut Erbas
0000-0003-3996-7094
Türkiye

Publication Date

July 21, 2020

Submission Date

June 1, 2020

Acceptance Date

July 14, 2020

Published in Issue

Year 2020 Volume: 42 Number: 2

DOI

https://doi.org/10.7197/cmj.vi.746648

IZ

https://izlik.org/JA67TW66UZ

Cite

RIS / Bibtex

AMA

1.Çelik H, Erbas M. The predictive value of mean platelet volume, neutrophil lymphocyte ratio and platelet lymphocyte ratio in acute middle cerebral artery infarction patients. CMJ. 2020;42(2):179-184. doi:10.7197/cmj.vi.746648