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The relationship between paraoxonase, arylesterase, lipoprotein (a) and other lipid parameters in patients with coronary heart disease
Abstract
Objective: Millions of people die every year in industrialized countries due to coronary heart disease (CHD) and rank first among the causes of mortality. It is vital to know the causes of CHD and to determine early diagnosis methods. Low antioxidant enzyme paraoxonase (PONl) activity in High Density Lipoprotein (HDL) structure, which prevents Low Density Lipoprotein (LDL) oxidation, is a risk factor for CHD.
Method: For this purpose, serum PONl activities, ARE activities, Lp (a), apo A, apo B and other lipid parameters were investigated in 80 patients who were diagnosed with CHD who applied to the Cardiology Clinic of Fırat University Medical Faculty Hospital. CHD group; It consists of coronary heart patients who have undergone myocardial infarction to the cardiology outpatient clinic, or who have decided to by-pass operation as a result of coronary angiography, who use antiischemic drugs, have no diabetes, do not drink alcohol and smoke, do not have coronary heart disease in the family history, do not take lipid-lowering drugs. The control group consists of 40 healthy individuals without cardiovascular disease, diabetes or a disease affecting serum lipid level.
Results: Cholesterol, triglyceride (TG), HDL, LDL, VLDL, serum PONl and ARE activities, Lp (a), apo A and apo B levels were found statistically significant in the CHD compared to the healthy control group (p <0.05). Serum PONl activity and ARE activity were lower in the patient groups compared to the healthy control group, and serum Lp (a) levels were higher (p <0.05).
Conclusions: Serum PONI activity serum Lp (a) levels, which are accepted as important parameters in the diagnosis of CHD, were also found to be significant biochemical markers in our study.
Keywords
Supporting Institution
Fırat Üniversitesi Araştırma Fonu (FÜNAF-514)
Project Number
FÜNAF-514
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
October 27, 2020
Submission Date
July 8, 2020
Acceptance Date
September 21, 2020
Published in Issue
Year 2020 Volume: 42 Number: 3