Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abdisa Tufa; Ayça Taş; Tuğba Ağbektaş; Ömer Topcu; Solomon Genet; Yavuz Siliğ

doi:10.7197/cmj.907003

EN

Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abstract

Objective: We aimed to analyzed the association between gastric cancer and polymorphism of XPO5 gene.

Method: The polymorphism in the XPO5 gene (rs11544382) was determined in 120 individuals (60 gastric cancer patients; 60 healthy controls) using Real-Time PCR method.

Results: The comparison of gastric cancer patients and controls revealed a statistically significant relationship for alcoholic drink consumption (p<0.05).The relationship between XPO5 gene (rs11544382) polymorphism and gastric cancer was statistically not significant. There was no a statistically significant relationship between mutant (GG) genotype with both wild type (AA) and heterozygous (AG) polymorphic genotypes when evaluated in XPO5 polymorphism gastric cancer patients and control groups (χ2:0.12, p=0.729). The heterozygous (AG) was dominant in gastric cancers patients and control subjects, 93.3 and 91.7% respectively.

Conclusions: This study provides information about allele

and genotype frequency distribution of XPO5 gene polymorphism (rs11544382) in Turkish At the same time, AG genotype was found to be dominant in gastric cancer patients and their controls.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Abdisa Tufa
0000-0003-2196-6835
Ethiopia

Ayça Taş ^*
0000-0002-7132-1325
Türkiye

Tuğba Ağbektaş
0000-0003-3433-8870
Türkiye

Ömer Topcu
0000-0002-1017-9820
Türkiye

Solomon Genet
0000-0002-5433-0107
Ethiopia

Yavuz Siliğ
0000-0002-0562-7457
Türkiye

Publication Date

September 30, 2021

Submission Date

May 21, 2021

Acceptance Date

September 26, 2021

Published in Issue

Year 1970 Volume: 43 Number: 3

DOI

https://doi.org/10.7197/cmj.907003

IZ

https://izlik.org/JA98ZL67PW

Cite

RIS / Bibtex

AMA

1.Tufa A, Taş A, Ağbektaş T, Topcu Ö, Genet S, Siliğ Y. Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer. CMJ. 2021;43(3):254-262. doi:10.7197/cmj.907003

Öz

Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite