Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome

Sibel Yucel Kocak; Arzu Ozdemir

doi:10.7197/cmj.909706

EN

Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome

Abstract

Objective: It’s recommended to use equations such as Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) by using creatinine level in estimating glomerular filtration rate (GFR). Here, we aimed to compare serum cystatin-C (Cys-C) and Cys-C based equations with creatinine and creatinine based equations in patients with chronic kidney disease (CKD) and nephrotic syndrome (NS).

Method: A total of 142 patients with CKD (30 with NS and 112 without NS) followed in the nephrology outpatient clinic were included into the study. The patients were divided into two groups as NS (n=30) and non-NS (n=112).

Results: Out of 142 patients, 74 (52.1%) were male. Mean age of the patients was 51.94 ± 14.23 years (17-80). There was no significant difference in terms of age, gender and diabetes prevalence rates between the patients with NS and non-NS (p>0.05). Proteinuria was 6300.77 ± 3192.47 grams in the NS group and 1112.09 ±1004.36 grams in the non-NS group (p=0.001). Total cholesterol and LDL values were found to be significantly higher in patients with NS (p=0.033 and p=0.017, respectively). While there was no difference in serum creatinine level between the two groups, the Cys-C value in the NS group was found to be significantly higher than those of non-NS group (2.44 ± 0.94 vs 2.00 ± 0.99; p=0.014). CKD-EPI-CysC GFR and CKD-EPI Cr-CysC values were found to be significantly lower in the NS group than in the non-NS group (p=0.025, p=0.042, respectively). No significant difference was found between the two groups in CKD-EPI-Cr, MDRD formula and creatinine clearance.

Conclusions: Formulas based on alternative markers such as Cys-C may be more advantageous for the correct estimation of GFR. In this study, we showed that CKD-EPI-CysC and CKD-EPI Cr-CysC are better in detecting CKD than others in the evaluation of renal functions in NS.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sibel Yucel Kocak ^*
0000-0003-3984-4043
Türkiye

Arzu Ozdemir
0000-0001-7651-7282
Türkiye

Publication Date

July 1, 2021

Submission Date

April 7, 2021

Acceptance Date

May 19, 2021

Published in Issue

Year 2021 Volume: 43 Number: 2

DOI

https://doi.org/10.7197/cmj.909706

IZ

https://izlik.org/JA33RY39XP

Cite

RIS / Bibtex

AMA

1.Yucel Kocak S, Ozdemir A. Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome. CMJ. 2021;43(2):159-166. doi:10.7197/cmj.909706

Cited By

Association between combined healthy lifestyle score and risk of kidney stones: a cross-sectional study in US adults

Critical Public Health

https://doi.org/10.1080/09581596.2026.2624914

Öz

Comparison of creatinine, cystatin, CKD-EPI cystatin C, CKD-EPI creatinine and MDRD equations in estimating glomerular filtration rate in patients with nephrotic syndrome

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Association between combined healthy lifestyle score and risk of kidney stones: a cross-sectional study in US adults