Aim: Nesfatin-1 is a recently discovered adipocytokine that is believed to regulate food intake and is linked to body mass index. While its precise mechanism of action remains unclear, a deeper understanding of how nesfatin-1 interacts with metabolic diseases, inflammation, and insulin resistance could have significant implications for the treatment of a wide range of conditions, including cardiovascular disease.
Smoking is a complex issue with roots in social, cultural, and economic factors that can contribute to nicotine addiction. Additionally, nicotine's ability to stimulate the mind and promote feelings of relaxation can create a positive feedback loop that makes it difficult to quit. Unfortunately, there is limited research on the effects of smoking on Nesfatin-1 levels. However, one study found that women who smoke tend to have lower levels of Nesfatin-1. To build on this finding, the present study aims to further investigate nesfatin-1 levels in both smokers and non-smokers.
Methods: A total of 70 participants, smokers (n=35) and non-smokers (n=35), were included in the study. The participant's gender, age, height and weight, body mass index, and nesfatin-1 levels were measured and compared.
The SPSS 23.0 program was used to evaluate the data statistically. Data were evaluated with a t-test. The error level was taken as 0.05.
Result: Serum Nesfatin-1 levels were significantly higher in smokers (13.73± 3.11) than in non-smokers (8.63 ± 0.91) (t=-9.315, p<0.01). No significant difference was found between other parameters in the smoker and non-smoker groups.
Conclusion: Our study has shown that individuals who smoke display higher levels of Nesfatin-1 compared to non-smokers, indicating a correlation between smoking and Nesfatin-1. However, further investigation is required to understand the mechanism behind this increase. It is hoped that continued research will unveil the potential of Nesfatin-1 in treating human obesity.
Prior to conducting the research, appropriate permissions and ethical clearance were secured from the (No. 2019-03/02) was obtained from the Sivas Cumhuriyet University Faculty of Medicine Ethics Committee. In this manner, individuals provided informed consent before their participation.
Primary Language | English |
---|---|
Subjects | Health Services and Systems (Other) |
Journal Section | Medical Science Research Articles |
Authors | |
Publication Date | December 31, 2023 |
Submission Date | December 27, 2023 |
Acceptance Date | December 28, 2023 |
Published in Issue | Year 2023 |