Abstract
Adrenolökodistrofi: Manyetik Rezonans ve Difüzyon Ağırlıklı Görüntüleme
Bulguları
ÖZET
Adrenolökodistrofi (ALD), adrenal
korteks ve santral sinir sisteminin etkilendiği adrenal yetmezlik ve demiyelinasyona
bağlı nörolojik bulgularla seyreden nadir genetik bir hastalıktır. Bu
bozukluğun temel histopatolojik özellikleri, beyaz cevherde demiyelinasyon ve
aksonal kaybıdır. ALD gibi lökodistrofi tanısı alan hastalarda altta yatan
beyaz cevher anormalilerinin karakterizasyonu, lokalizasyonu ve ayırıcı
tanısında MRG öncelikli görüntüleme yöntemidir. Bu yazıda adrenolökodistrofi
tanısı alan 9 yaşındaki erkek olguda manyetik rezonans görüntüleme ve difüzyon
ağırlıklı görüntüleme bulgularının kliniğe katkısını sunmayı amaçladık.
Adrenoleukodystrophy: Magnetic
Resonance and Diffusion Weighted Imaging Findings
ABSTRACT
Adrenoleukodystrophy (ALD) is
a rare genetic disorder characterized by adrenal failure affecting adrenal
cortex and central nervous system and demyelination-related neurological signs.
The basic histopathological properties of this disorder are white matter
demyelination and axonal loss. In patients diagnosed with a leukodystrophy such
as ALD, magnetic resonance imaging (MRI) is the primary imaging modality for
characterization, localization, and differential diagnosis of underlying white
matter abnormalities. Herein, we aimed to report the contribution of MRI and
diffusion-weighted imaging (DWI) findings to clinical findings of the disorder
in a 9-year-old boy diagnosed with adrenoleukodystrophy.
References
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- Reference2 Barkovich AJ, Ferriero DM, Bass N, Boyer R. Involvement of the pontomedullary corticospinal tracts; a usefull finding in the diagnosis of X-linked adrenoleukodystropy. AJNR Am J Neuroradiol. 1997; 18: 95-100.
- Reference3 Yüzbaş Çekiç P, Biçeroğlu S, Sener RN. Adrenoleukodystrophy: Diffusion MRI findings. Journal of Pediatric Neurology. 2005; 3: 277–8.
- Reference4 Sener RN. Atypical X-linked adrenoleukodystrophy: new MRI observations with FLAIR, magnetization transfer contrast, diffusion MRI, and proton spectroscopy. Magn Reson Imaging. 2002; 20: 215–9.
- Reference5 Mutlu DY, Fırat A, Karakaş HM, Erdem G, Fırat Y, Güngör S. Adrenolökodistrofinin Manyetik Rezonans Görüntüleme Bulguları: Spektroskopi Ve Difüzyon Ağırlıklı Görüntülemenin Tanıya Katkısı. İnönü Üniversitesi Tıp Fakültesi Dergisi. 2008; 15: 103-7.
- Reference6 Şener RN. Atypical X-linked adrenoleukodystrophy: new MRI observations with FLAIR, magnetization transfer contrast, diffusion MRI, and proton spectroscopy. Magnetic Resonance Imaging. 2002; 20: 215–9.
- Reference7 Segawa F, Kishibayashi J, Kamada K, Sunohara N, Kinoshita M. Diffusion anisotropy in cerebral white matter lesion. No To Shinkei. 1994; 46: 765–70.
- Reference8 Santosh Rai PV, Suresh BV, Bhat IG, Sekhar M, Chakraborti S. Childhood adrenoleukodystrophy - Classic and variant - Review of clinical manifestations and magnetic resonance imaging. J Pediatr Neurosci. 2013; 8: 192-7.
Abstract
References
- Reference1 Mooser HW. Adrenoleukodystrophy; phenotype, genetics, patogenezis and terapy. Brain. 1997; 120: 1485-1508.
- Reference2 Barkovich AJ, Ferriero DM, Bass N, Boyer R. Involvement of the pontomedullary corticospinal tracts; a usefull finding in the diagnosis of X-linked adrenoleukodystropy. AJNR Am J Neuroradiol. 1997; 18: 95-100.
- Reference3 Yüzbaş Çekiç P, Biçeroğlu S, Sener RN. Adrenoleukodystrophy: Diffusion MRI findings. Journal of Pediatric Neurology. 2005; 3: 277–8.
- Reference4 Sener RN. Atypical X-linked adrenoleukodystrophy: new MRI observations with FLAIR, magnetization transfer contrast, diffusion MRI, and proton spectroscopy. Magn Reson Imaging. 2002; 20: 215–9.
- Reference5 Mutlu DY, Fırat A, Karakaş HM, Erdem G, Fırat Y, Güngör S. Adrenolökodistrofinin Manyetik Rezonans Görüntüleme Bulguları: Spektroskopi Ve Difüzyon Ağırlıklı Görüntülemenin Tanıya Katkısı. İnönü Üniversitesi Tıp Fakültesi Dergisi. 2008; 15: 103-7.
- Reference6 Şener RN. Atypical X-linked adrenoleukodystrophy: new MRI observations with FLAIR, magnetization transfer contrast, diffusion MRI, and proton spectroscopy. Magnetic Resonance Imaging. 2002; 20: 215–9.
- Reference7 Segawa F, Kishibayashi J, Kamada K, Sunohara N, Kinoshita M. Diffusion anisotropy in cerebral white matter lesion. No To Shinkei. 1994; 46: 765–70.
- Reference8 Santosh Rai PV, Suresh BV, Bhat IG, Sekhar M, Chakraborti S. Childhood adrenoleukodystrophy - Classic and variant - Review of clinical manifestations and magnetic resonance imaging. J Pediatr Neurosci. 2013; 8: 192-7.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | September 30, 2018 |
| Acceptance Date | July 10, 2018 |
| Published in Issue | Year 2018 |