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Mean Platelet Volume (MPV) is Correlated with Body Mass Index

Year 2018, , 432 - 437, 29.12.2018

Naim Ata

https://doi.org/10.7197/223.vi.491832

Abstract

Objectıves:Obesity is a common health problem all over the world, leading to significant chronic diseases such as diabetes mellitus, hypertension and coronary artery disease. Platelets are one of the blood components that play a role in a number of important pathways such as inflammation and endothelial activation other than hemostasis. They become more metabolically active as their volume increases. In many studies increase in MPV has negative effects on acute coronary syndrome, stent thrombosis and serbrovascular events. In this study, it was aimed to evaluate whether there is a correlation between body mass index (BMI) used in the definition and classification of obesity and mean platelet volume (MPV). 

Methods:Seventy-two patients who presented to the internal medicine outpatient clinic due to obesity and had no hypertension, diabetes mellitus and hyperlipidemia were included in the study. After the basal demographic characteristics of the patients were recorded, transthoracic echocardiographic examination was performed to exclude possible cardiac pathologies.Examples of routine biochemistry and blood parameters were obtained and analyzed 

Results:The mean age of the patients was 45.06 (± 10.69) years, and the mean BMI was determined as 43.4 kg / m2 (± 5.3).Transthoracic echocardiographic examinations were found within normal limits. The mean platelet volume was 8.57 fL (± 1.22) and there was a positive correlation between BMI and MPV (p: 0.004, r: 0.319).No significant correlation was found with other parameters.

Conclusıons:Increase in body mass index is corroleted with increase in MPV values. MPV increase may play a role in the etiopathogenesis of chronic diseases associated with BMI increase in obesity patients.


Keywords

Obesity. Body mass index

References

  • 1. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004;103:2096-2104.
  • 2. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384)
  • 3. Vagdatli E., Gounari E., Lazaridou E., Katsibourlia E., Tsikopoulou F., Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28–32
  • 4. Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004;35:1688- 1691
  • 5. Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. JAm Coll Cardiol 2005;46:284-290.
  • 6. Goncalves SC, Labinaz M, Le May M, Glover C, Froeschl M, Marquis JF, O'Brien E, et al. Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention. Am J Cardiol 2011;107:204-209
  • 7. WHO. Obesity: preventing and managing the global epidemic. 2000. Geneva, World Health Organization. Ref Type: Generic
  • 8. Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A,, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovasculardisease: collaborative analysis of 58 prospective studies. Emerging Risk Factors Collaboration, Lancet. 2011 Mar 26;377(9771):1085–95.
  • 9. Al Rifai M, Silverman MG, Nasir K, Budoff MJ, Blankstein R, Szklo Met al. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015Apr;239(2):629–33. doi: 10.1016/j.atherosclerosis.2015.02.011.
  • 10. Das SR1, Alexander KP, Chen AY, Powell-Wiley TM, Diercks DB, Peterson ED et al. Impact of body weight and extreme obesity on the presentation, treatment, and in-hospitaloutcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry).J Am Coll Cardiol. 2011 Dec 13;58(25):2642-50. doi: 10.1016/j.jacc.2011.09.030.
  • 11. Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications. 2004;18: 173–6.
  • 12. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets. 2006;17:67–9.
  • 13. Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010; 56:154–8.
  • 14. Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol. 2004;44:415–22.
  • 15. Coban E, Afacan B. The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelets. 2008;19:111–4.
  • 16. Demirtunc R, Duman D, Basar M. Effects of doxazosin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study. Clin Drug Investig. 2007;27:435–41.

Obezlerde Ortalama Platelet Hacmi (MPV), Vücut Kitle İndeksi ile Koreledir

Year 2018, , 432 - 437, 29.12.2018

Naim Ata

https://doi.org/10.7197/223.vi.491832

Abstract

Amaç: Obezite, tüm dünyada giderek yaygınlaşan, diabetes mellitus, hipertansiyon ve koroner arter hastalığı gibi önemli kronik hastalıklara yol açan bir sağlık problemidir. Trombositler, hemostaz dışında inflamasyon ve endotel aktivasyonu gibi bir çok önemli yolakta rol oynayan kan bileşenlerinden biridir. Hacimleri artıkça metabolik olarak daha aktif olurlar. Yapılan bir çok çalışmada MPV artışının;  akut koroner sendrom, stent trombozu ve serbrovasküler olay seyrinde olumsuz etkilerinin olduğu görülmüştür.   Bu çalışmada obezite tanım ve sınıflandırmasında kullanılan vücut kitle İNDEKSİ (VKİ) ve ortalama trombosit hacmi (MPV) arasında korelasyonun olup olmadığının değerlendirilmesi amaçlanmıştır.

Gereç ve yöntemler: Obezite nedeni ile dahiliye polikliniğine başvuran ve hipertansiyon diabetes mellitus ve hiperlipidemi saptanmayan 78 hasta çalışmaya dahil edilmiştir. Hastaların bazal demografik özellikleri kayıt edildikten sonra olası kardiyak patolojileri dışlamak için transtorasik ekokardiyografik inceleme yapılmıştır. Rutin biyokimya ve kan parametleri için örnekler alınıp incelenmiştir  

Bulgular:Hastaların ortalama yaşları 45.06 (±10.69)  yıl olup, ortalama VKİ 43.4 kg/m2(±5.3) olarak tespit edilmiştir. Transtorasik ekokardiyografik incelemeleri normal sınırlarda tespit edilmiştir. Ortalama trombosit hacimleri 8.57 fL(±1.22) olup VKİ ile MPV arasında pozitif korelasyon saptanmıştır (p:0.004, r:0.319). Diğer parametler ile anlamlı korelasyon tespit edilmememiştir.

Sonuç: Vücut kitle İNDEKSİ artışı MPV değerindeki artış ile koroledir. Obezite hastalarında VKİ artış ile birlkte görülen kronik hastalıkların etyopatogenizde MPV artışı rol oynayabilir.

Keywords

Obezite Vücut kitle indeksi

References

  • 1. Coppinger JA, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond JP, et al. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood 2004;103:2096-2104.
  • 2. Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis. J Clin Invest 2005;115:3378-3384)
  • 3. Vagdatli E., Gounari E., Lazaridou E., Katsibourlia E., Tsikopoulou F., Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28–32
  • 4. Greisenegger S, Endler G, Hsieh K, Tentschert S, Mannhalter C, Lalouschek W. Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events? Stroke 2004;35:1688- 1691
  • 5. Huczek Z, Kochman J, Filipiak KJ, Horszczaruk GJ, Grabowski M, Piatkowski R, et al. Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention. JAm Coll Cardiol 2005;46:284-290.
  • 6. Goncalves SC, Labinaz M, Le May M, Glover C, Froeschl M, Marquis JF, O'Brien E, et al. Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention. Am J Cardiol 2011;107:204-209
  • 7. WHO. Obesity: preventing and managing the global epidemic. 2000. Geneva, World Health Organization. Ref Type: Generic
  • 8. Wormser D, Kaptoge S, Di Angelantonio E, Wood AM, Pennells L, Thompson A,, et al. Separate and combined associations of body-mass index and abdominal adiposity with cardiovasculardisease: collaborative analysis of 58 prospective studies. Emerging Risk Factors Collaboration, Lancet. 2011 Mar 26;377(9771):1085–95.
  • 9. Al Rifai M, Silverman MG, Nasir K, Budoff MJ, Blankstein R, Szklo Met al. The association of nonalcoholic fatty liver disease, obesity, and metabolic syndrome, with systemic inflammation and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2015Apr;239(2):629–33. doi: 10.1016/j.atherosclerosis.2015.02.011.
  • 10. Das SR1, Alexander KP, Chen AY, Powell-Wiley TM, Diercks DB, Peterson ED et al. Impact of body weight and extreme obesity on the presentation, treatment, and in-hospitaloutcomes of 50,149 patients with ST-Segment elevation myocardial infarction results from the NCDR (National Cardiovascular Data Registry).J Am Coll Cardiol. 2011 Dec 13;58(25):2642-50. doi: 10.1016/j.jacc.2011.09.030.
  • 11. Hekimsoy Z, Payzin B, Ornek T, Kandogan G. Mean platelet volume in type 2 diabetic patients. J Diabetes Complications. 2004;18: 173–6.
  • 12. Coban E, Bostan F, Ozdogan M. The mean platelet volume in subjects with impaired fasting glucose. Platelets. 2006;17:67–9.
  • 13. Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010; 56:154–8.
  • 14. Nadar SK, Blann AD, Kamath S, Beevers DG, Lip GY. Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Am Coll Cardiol. 2004;44:415–22.
  • 15. Coban E, Afacan B. The effect of rosuvastatin treatment on the mean platelet volume in patients with uncontrolled primary dyslipidemia with hypolipidemic diet treatment. Platelets. 2008;19:111–4.
  • 16. Demirtunc R, Duman D, Basar M. Effects of doxazosin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study. Clin Drug Investig. 2007;27:435–41.
There are 16 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Medical Science Research Articles
Authors

Naim Ata

Publication Date December 29, 2018
Acceptance Date December 26, 2018
Published in Issue Year 2018

Cite

AMA Ata N. Obezlerde Ortalama Platelet Hacmi (MPV), Vücut Kitle İndeksi ile Koreledir. CMJ. December 2018;40(4):432-437. doi:10.7197/223.vi.491832