Research Article
Year 2019,
, 537 - 543, 30.09.2019
Abstract
References
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The incidences of upper gastrointestinal and colorectal malignancies in Ağrı city of eastern Anatolia
Abstract
Objective: Gastrointestinal
tract malignancies comprise essential morbidity and mortality reasons in east
Anatolia. The data regarding the incidences and clinical symptoms of these
malignancies in this region are scarce.
Method: All
endoscopic interventions and obtained biopsies between July 2014 and August
2015 were reviewed retrospectively. Age-adjusted and crude incidences were
calculated according to the mid- population
number in 2014 given by the regional governorship.
Results: A total of 1176 endoscopic interventions (927 (78.8%)
upper endoscopy and 249 (21.2%) colonoscopy) were performed within 12 months of
time interval. As a result of these endoscopic interventions, 14 (19.1%)
esophageal cancers, 49 (67.1%) gastric cancers, and 10 (13.6%) colorectal cancers
were diagnosed. Crude incidences per 100.000 individuals for esophageal cancer
were 2.4 and 2.6, for gastric cancer were 9.1 and 8.3, and for colorectal cancer
were 2.8 and 0.7 for men and women, respectively. Gender and age-adjusted
esophageal cancer rates per 100.000 individuals for men between 30-34 years was
0.34 and for women between 40-44 years was 3.03. While weight loss was more
common in upper gastrointestinal malignancies (49.2% vs. 10%, p<0.001),
anemia was more common in colorectal malignancies (90% vs. 15.8%, p=0.02).
Conclusions:
When age-adjusted cancer rates were taken into
consideration, the esophageal cancer rate in young men and women was shown to
be increased in Ağrı province, contrary to Turkey’s general. Despite an
increase in the crude incidence of gastric cancer, when adjusted to age, the
incidence seems to be in accordance with the general tendency.
Keywords
References
- 1. Wright NA, Poulsom R, Stamp G, et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 1993;104:12–20.
- 2. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin 2011;6:69–90.
- 3. Sitarz R, Skierucha M, Mielko J, et al. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manag Res 2018;10:239-248.
- 4. Wheeler JB, Reed CE. Epidemiology of esophageal cancer. The Surgical Clinics of North America 2012; 92:1077–87.
- 5. GLOBOCAN. Estimated number of colorectal cancer new cases in 2018, worldwide, both sexes, all ages Cancer Today 2018 [cited 2018 October,19, 2018]; Available from: https://gco.iarc.fr/today/ online-analysis table?v=2018 &mode= cancer&mode_population= continents&population=900&populations=900&key=asr&sex=0&cancer=39&type=0&statistic=5&prevalence=0&population_group=0&ages_group%5B%5D=0&ages_group%5B%5D= 17&nb_items=5&group_cancer=1&include_nmsc=1&include_ nmsc_other=1.
- 6. Bray, F. , Ferlay, J. , Soerjomataram, I. , et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2018; 68: 394-424. doi:10.3322/caac.214927.
- 7. Boyle P, Longman JS. ABC of colrectal cancer: Epidemiology. BMJ 2000; 321: 805-8.
- 8. HSGM. Cancer Statistics of Turkey in 2014. https://hsgm.saglik.gov.tr/tr/kanser istatistikleri/yillar/495-2014-y%C4%B1l%C4%B1-t%C3%BCrkiye-kanser-istatistikleri.html
- 9. İstatiksel Göstergeler/ Bölgesel İstatikler/ 2014 Nüfus ve Göç verileri. tuik.gov.tr/Start.do
- 10. Türkdogan MK, Akman N, Tuncer I, et al. Epidemiological aspects of endemic upper gastrointestinal cancers in eastern Turkey. Hepatogastroenterology 2005;52:496-500.
- 11. Binici DN, Koca T, Dursun H. Dietary Habits, demographical, and socio-economical risk factors of the newly diagnosed gastric cancers in the Eastern Anatolia Region of Turkey: an endemic upper gastrointestinal cancer region. Dig Dis Sci 2009;54:2629-33.
- 12. Suleyman C, Atakan Y, Ipek C, İsmail B, Ogun A. Annually Incidence of Esophagus Cancer in the Hakkari City of Eastern Anatolia. Journal of Gastroenterology and Hepatology Research 2013; 2: 696-698.
- 13. Topcu N, Ilhan M, Koca D, et al. Analysis of 3065 cancer cases in an Eastern part of Turkey: The results of hospital-based registries from Van Region. Annals of Oncology 2004; 15(Supplement 3): 560.
- 14. Corley DA and Buffler PA. Oesophageal and gastric cardia adenocarcinomas: analysis of regional variation using the cancer incidence in five continents database. International Journal of Epidemiology 2001; 30: 1415–1425.
- 15. Pera M, Manterola C, Vidal O, and Grande L. Epidemiology of esophageal adenocarcinoma. Journal of Surgical Oncology 2005; 92: 151–159.
- 16. Yousefi MS, Sharifi-Esfahani M, Pourgholam-Amiji N, et al. Esophageal cancer in the world: incidence, mortality and risk factors 2018; 5: 2504-2517.
- 17. Aykan NF, Yalçın S, Turhal NS, et al. Epidemiology of colorectal cancer in Turkey: A cross-sectional disease registry study (A Turkish Oncology Group trial). Turk J Gastroenterol 2015; 26: 145-53.
There are 17 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | September 30, 2019 |
| Acceptance Date | September 25, 2019 |
| Published in Issue | Year 2019 |