Research Article
Year 2021,
, 377 - 383, 31.12.2021
Abstract
References
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- 3. Saini V. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes. 2010; July 15; 1(3): 68-75.
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- 5. Ebert T, Bachmann A, Lössner U, et al. Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis. Metabolism. 2009;58:547–51.
- 6. Abdullah B, Deveci K, Atilgan R, Kiliçli F, Söylemez MS. Serum angiopoietin-related growth factor (AGF) levels are elevated in gestational diabetes mellitus and associated with insulin resistance. Ginekol Pol. 2012 Oct;83(10):749-53.
- 7. Oike, Y. et al. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood.2004; 103(10), 3760–3765.
- 8. Oike, Y. et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med. 2005; 11(4), 400–408.
- 9. Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 2011;278:559–64.
- 10. Stepan H, Ebert T, Schrey S, Reisenbuchler C, Stein S, Lossner U, Bluher M, Stumvoll M, Kratzsch J, Faber R, Fasshauer M. Serum levels of angiopoietin-related growth factor are increased in preeclampsia. Am J Hypertens 2009;22:314-8.
- 11. Boztosun A, Deveci K, Klcl F, Soylemez MS, Muhtaroglu S. Serum levels of angiopoietin-related growth factor (AGF) are increased in polycystic ovary syndrome. J Investig Med 2012;60:813-7.
- 12. Ebert T, Kralisch S, Loessner U, Jessnitzer B, Stumvoll M, Fasshauer M, Tonjes A. Relationship between serum levels of angiopoietin-related growth factor and metabolic risk factors. Horm Metab Res 2014;46:685-90. 13. Namkung J, Koh SB, Kong ID, Choi JW, Yeh BI. Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome. Metabolism 2011;60:564-8.
- 14. Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim DH, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2013;19:83-92.
- 15. Kim MJ, Namkung J, Chang JS, Kim SJ, Park KS, Kong ID. Leptin regulates the expression of angiopoietin-like 6. Biochem Biophys Res Commun 2018;502:397-402.
- 16. Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol 2017;233:105-18.
- 17. Jun Namkung, Joon HS , Jae SC , Sang- WP, Jang Y, Sang-BK , In Deok K, Kyu-Sang P. Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study. Diabetes Metab J 2019;43:521-529
Year 2021,
, 377 - 383, 31.12.2021
Abstract
Obesity is an increasing health problem all over the world. Angiopoietin-related growth factor (AGF, ANGPTL6) is a hepatocyte that directly regulates lipid, glucose and energy metabolism independent of angiogenic effects. In this study, we investigated circulating AGF levels in relation to kidney function, type 2 diabetes mellitus and insulin resistance. Angiopoietin-related growth factor was determined by enzyme-linked immunosorbent assay in subjects with a normal glomerular filtration rate (n = 44, 22 diabetic and 22 nondiabetic) and in patients on chronic hemodialysis (CD; n = 44, 22 diabetic and 22 nondiabetic). Median serum AGF levels were 176,6± 96,6 μg/L inpatients who underwent dialysis and 186,0±81,7 μg/L in patients not on dialysis. There was no statistically significant difference between the mean serum AGF levels of the patients who underwent dialysis and those who did not(p>0.05). AGF serum levels were significantly increased in diabetic patients (222,56±90,61 μg/L) as compared with non-diabetic patients (140,12 ± 66,06 μg/L) (P <0.05). In addition, we evaluated the relationship between biochemical parameters and anthropometric measurements of the patients and AGF in our study. BMI, HOMA, waist/hip circumference ratios positively correlated with circulating AGF in all patients. Our results suggest that T2DM is positively associated with AGF serum levels. We think that this study will be useful to explain the pathogenesis of AGF in insulin resistance. Further studies are needed to better elucidate the physiologic significance of circulating AGF in human.
References
- 1. Reaven GM. The insulin resistance syndrome: definition and dietary approaches to treatment. Annu Rev Nutr . 2005; 25, 391– 406.
- 2. Kitazawa M, Ohizumi Y, Oike Y, Hishinuma T, Hashimoto S. Angiopoietin-related growth factor suppresses gluconeogenesis through the Akt/forkhead box class O1-dependent pathway in hepatocytes. J Pharmacol Exp Ther. 2007; Dec ;323(3):787-93.
- 3. Saini V. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J Diabetes. 2010; July 15; 1(3): 68-75.
- 4. Lu B, Yang Y. Insulin resistance in Chinese patients with type 2 diabetes is associated with C-reactive protein independent of abdominal obesity. Cardiovascular Diabetology. 2010; 9:92.
- 5. Ebert T, Bachmann A, Lössner U, et al. Serum levels of angiopoietin-related growth factor in diabetes mellitus and chronic hemodialysis. Metabolism. 2009;58:547–51.
- 6. Abdullah B, Deveci K, Atilgan R, Kiliçli F, Söylemez MS. Serum angiopoietin-related growth factor (AGF) levels are elevated in gestational diabetes mellitus and associated with insulin resistance. Ginekol Pol. 2012 Oct;83(10):749-53.
- 7. Oike, Y. et al. Angiopoietin-related growth factor (AGF) promotes angiogenesis. Blood.2004; 103(10), 3760–3765.
- 8. Oike, Y. et al. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med. 2005; 11(4), 400–408.
- 9. Kadomatsu T, Tabata M, Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 2011;278:559–64.
- 10. Stepan H, Ebert T, Schrey S, Reisenbuchler C, Stein S, Lossner U, Bluher M, Stumvoll M, Kratzsch J, Faber R, Fasshauer M. Serum levels of angiopoietin-related growth factor are increased in preeclampsia. Am J Hypertens 2009;22:314-8.
- 11. Boztosun A, Deveci K, Klcl F, Soylemez MS, Muhtaroglu S. Serum levels of angiopoietin-related growth factor (AGF) are increased in polycystic ovary syndrome. J Investig Med 2012;60:813-7.
- 12. Ebert T, Kralisch S, Loessner U, Jessnitzer B, Stumvoll M, Fasshauer M, Tonjes A. Relationship between serum levels of angiopoietin-related growth factor and metabolic risk factors. Horm Metab Res 2014;46:685-90. 13. Namkung J, Koh SB, Kong ID, Choi JW, Yeh BI. Serum levels of angiopoietin-related growth factor are increased in metabolic syndrome. Metabolism 2011;60:564-8.
- 14. Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim DH, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS. Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med 2013;19:83-92.
- 15. Kim MJ, Namkung J, Chang JS, Kim SJ, Park KS, Kong ID. Leptin regulates the expression of angiopoietin-like 6. Biochem Biophys Res Commun 2018;502:397-402.
- 16. Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M. ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21. J Endocrinol 2017;233:105-18.
- 17. Jun Namkung, Joon HS , Jae SC , Sang- WP, Jang Y, Sang-BK , In Deok K, Kyu-Sang P. Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study. Diabetes Metab J 2019;43:521-529
There are 16 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | December 31, 2021 |
| Acceptance Date | December 29, 2021 |
| Published in Issue | Year 2021 |