Research Article
DETERMINATION OF CHANGES IN VITAMIN D, FOLIC ACID AND VITAMIN B12 LEVELS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT AFTER SUICIDAL INTERVENTIONS
Abstract
ABSTRACT
Introduction: Depression is a psychological and physiological destruction process. In recent years, it has been one of the leading causes of public health problems in our country and in the world. Patients with depressive mood are at a higher risk compared to the normal population in terms of realizing suicidal ideation. Since the first place of application after a suicide attempt is usually the emergency services, the studies carried out in the ED are extremely important in this sense.
Methods: Data in the study were analyzed using SPSS Data:23.0 (SPSS Inc., Chicago, Illinois, USA). Continuous variables were expressed as mean ± standard deviation (SD). In the evaluation of the data, the significance test of the difference between the two means (Independent t test) was used when the parametric test assumptions were fulfilled, and the Man Whitney U test was used when the parametric test assumptions were not fulfilled.
Results: In our study, we compared the levels of vitamin D, folic acid and vitamin B12 in patients who applied to the emergency department after a suicide attempt with the normal population. Vitamin D and vitamin B12 levels were found to be significantly lower in the patient group compared to the control group.
Conclusions: Our current clinical study supports many studies in the literature, with the detection of low levels of vitamin D and vitamin B12 after the examinations of the patient group who came to the emergency room with a depressive episode and the control group.
Project Number
yok
References
- 1. Chunmei Geng , Abdul Sami Shaikh , Wenxiu Han , Dan Chen 1, Yujin Guo , Pei Jiang . Vitamin D and depression: mechanisms, determination and application, Asia Pac J Clin Nutr. 2019;28(4):689-694.
- 2. Gülseren Nur Ekinci , Nevin Sanlier. The relationship between nutrition and depression in the life process: A mini-review, Exp Gerontol. 2023; 172.
- 3. GBD 2015 Mortality and Causes of Death Collaborators, Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459
- 4. Leo Sher , Maria A Oquendo . Suicide: An Overview for Clinicians, Med Clin North Am. 2023, 107(1):119-130. 5. Jean-Claude Guilland . What is a vitamin? Rev Prat. 2013, 63(8):1060-9.
- 6. Mohamed Said Boulkrane , Julia Fedotova , Valentina Kolodyaznaya , Vincenzo Micale , Filippo Drago , Annemieke Johanna Maria van den Tol , Denis Baranenko . Vitamin D and Depression in Women: A Mini-review Curr Neuropharmacol. 2020;18(4):288-300.
- 7. Adriana S Dusso , Alex J Brown, Eduardo Slatopolsky. Vitamin D, Am J Physiol Renal Physiol. 2005, 289(1):8-28.
- 8. Richard D Semba . Treatment of depression: time to consider folic acid and vitamin B12 J Psychopharmacol. 2005, 19(1):59-65.
- 9. Edward Reynolds . Vitamin B12, folic acid, and the nervous system, Lancet Neurol. 2006, 5(11):949-60.
- 10. Murphy, G.E. 1998. Why women are less likely than men to commit suicide. Compr. Psychiatry 39, 165–175.
- 11. Henderson, J.P. Mellin, C. Patel, F. 2005. Suicide—a statistical analysis by age, sex and method. J. Clin. Forensic Med. 12, 305–309
- 12. Massimiliano Beghi, Cesare Giuseppe Cerri , Cesare Maria Cornaggia , Francesca Febbo , Anita Mollica, Giuseppe Berardino , Daniele Piscitelli , Emanuela Resta , Giancarlo Logroscino, Antonio Daniele, Mario Altamura, Antonello Bellomo, Francesco Panza , Madia Lozupone. Suicidal behaviour in older age: A systematic review of risk factors associated to suicide attempts and completed suicides Neurosci Biobehav Rev. 2021, 127:193-211.
- 13. Richard D Semba . Treatment of depression: time to consider folic acid and vitamin B12 J Psychopharmacol. 2005 ,19(1):59-65.
- 14. Kathleen Mikkelsen, Lily Stojanovska, Vasso Apostolopoulos . The Effects of Vitamin B in Depression, Curr Med Chem. 2016;23(38):4317-4337.
- 15. David T Field , Rebekah O Cracknell , Jessica R Eastwood , Peter Scarfe , Claire M Williams , Ying Zheng , Teresa Tavassoli High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression, Hum Psychopharmacol. 2022, 37(6):e2852.
- 16. E H Reynolds . The neurology of folic acid deficiency, Handb Clin Neurol. 2014;120:927-43.
- 17. Chunmei Geng , Abdul Sami Shaikh 2, Wenxiu Han , Dan Chen , Yujin Guo , Pei Jiang Vitamin D and depression: mechanisms, determination and application,Asia Pac J Clin Nutr. 2019;28(4):689-694.
- 18. Gordon B Parker , Heather Brotchie , Rebecca K Graham. Vitamin D and depression J Affect Disord. 2017 Jan 15;208:56-61.
- 19. Gleicilaine A S Casseb , Manuella P Kaster , Ana Lúcia S Rodrigues Potential Role of Vitamin D for the Management of Depression and Anxiety, CNS Drugs. 2019,33(7):619-637.
- 20. Elisa J de Koning , Paul Lips , Brenda W J H Penninx , Petra J M Elders , Annemieke C Heijboer , Martin den Heijer , Pierre M Bet , Harm W J van Marwijk , Natasja M van Schoor. Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial, Am J Clin Nutr. 2019, 1;110(5):1119-1130.
- 21. Nithila Mariam Roy , Lara Al-Harthi , Neela Sampat , Rawan Al-Mujaini , Sangeetha Mahadevan , Samir Al Adawi , Musthafa Mohamed Essa , Lyutha Al Subhi , Buthaina Al-Balushi , M Walid Qoronfleh Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD, Front Biosci (Landmark Ed). 2021, 1;26(3):566-611.
Year 2023,
Volume: 45 Issue: 3, 85 - 90, 30.09.2023
Abstract
Supporting Institution
sivas cumhuriyet üniversitesi araştırma ve uygulama hastanesi
Project Number
yok
Thanks
bütün yazarlara teşekkür ederim.
References
- 1. Chunmei Geng , Abdul Sami Shaikh , Wenxiu Han , Dan Chen 1, Yujin Guo , Pei Jiang . Vitamin D and depression: mechanisms, determination and application, Asia Pac J Clin Nutr. 2019;28(4):689-694.
- 2. Gülseren Nur Ekinci , Nevin Sanlier. The relationship between nutrition and depression in the life process: A mini-review, Exp Gerontol. 2023; 172.
- 3. GBD 2015 Mortality and Causes of Death Collaborators, Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459
- 4. Leo Sher , Maria A Oquendo . Suicide: An Overview for Clinicians, Med Clin North Am. 2023, 107(1):119-130. 5. Jean-Claude Guilland . What is a vitamin? Rev Prat. 2013, 63(8):1060-9.
- 6. Mohamed Said Boulkrane , Julia Fedotova , Valentina Kolodyaznaya , Vincenzo Micale , Filippo Drago , Annemieke Johanna Maria van den Tol , Denis Baranenko . Vitamin D and Depression in Women: A Mini-review Curr Neuropharmacol. 2020;18(4):288-300.
- 7. Adriana S Dusso , Alex J Brown, Eduardo Slatopolsky. Vitamin D, Am J Physiol Renal Physiol. 2005, 289(1):8-28.
- 8. Richard D Semba . Treatment of depression: time to consider folic acid and vitamin B12 J Psychopharmacol. 2005, 19(1):59-65.
- 9. Edward Reynolds . Vitamin B12, folic acid, and the nervous system, Lancet Neurol. 2006, 5(11):949-60.
- 10. Murphy, G.E. 1998. Why women are less likely than men to commit suicide. Compr. Psychiatry 39, 165–175.
- 11. Henderson, J.P. Mellin, C. Patel, F. 2005. Suicide—a statistical analysis by age, sex and method. J. Clin. Forensic Med. 12, 305–309
- 12. Massimiliano Beghi, Cesare Giuseppe Cerri , Cesare Maria Cornaggia , Francesca Febbo , Anita Mollica, Giuseppe Berardino , Daniele Piscitelli , Emanuela Resta , Giancarlo Logroscino, Antonio Daniele, Mario Altamura, Antonello Bellomo, Francesco Panza , Madia Lozupone. Suicidal behaviour in older age: A systematic review of risk factors associated to suicide attempts and completed suicides Neurosci Biobehav Rev. 2021, 127:193-211.
- 13. Richard D Semba . Treatment of depression: time to consider folic acid and vitamin B12 J Psychopharmacol. 2005 ,19(1):59-65.
- 14. Kathleen Mikkelsen, Lily Stojanovska, Vasso Apostolopoulos . The Effects of Vitamin B in Depression, Curr Med Chem. 2016;23(38):4317-4337.
- 15. David T Field , Rebekah O Cracknell , Jessica R Eastwood , Peter Scarfe , Claire M Williams , Ying Zheng , Teresa Tavassoli High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression, Hum Psychopharmacol. 2022, 37(6):e2852.
- 16. E H Reynolds . The neurology of folic acid deficiency, Handb Clin Neurol. 2014;120:927-43.
- 17. Chunmei Geng , Abdul Sami Shaikh 2, Wenxiu Han , Dan Chen , Yujin Guo , Pei Jiang Vitamin D and depression: mechanisms, determination and application,Asia Pac J Clin Nutr. 2019;28(4):689-694.
- 18. Gordon B Parker , Heather Brotchie , Rebecca K Graham. Vitamin D and depression J Affect Disord. 2017 Jan 15;208:56-61.
- 19. Gleicilaine A S Casseb , Manuella P Kaster , Ana Lúcia S Rodrigues Potential Role of Vitamin D for the Management of Depression and Anxiety, CNS Drugs. 2019,33(7):619-637.
- 20. Elisa J de Koning , Paul Lips , Brenda W J H Penninx , Petra J M Elders , Annemieke C Heijboer , Martin den Heijer , Pierre M Bet , Harm W J van Marwijk , Natasja M van Schoor. Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial, Am J Clin Nutr. 2019, 1;110(5):1119-1130.
- 21. Nithila Mariam Roy , Lara Al-Harthi , Neela Sampat , Rawan Al-Mujaini , Sangeetha Mahadevan , Samir Al Adawi , Musthafa Mohamed Essa , Lyutha Al Subhi , Buthaina Al-Balushi , M Walid Qoronfleh Impact of vitamin D on neurocognitive function in dementia, depression, schizophrenia and ADHD, Front Biosci (Landmark Ed). 2021, 1;26(3):566-611.
There are 20 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Implementation Science and Evaluation |
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Project Number | yok |
| Publication Date | September 30, 2023 |
| Acceptance Date | September 26, 2023 |
| Published in Issue | Year 2023Volume: 45 Issue: 3 |
