Miyelodisplastik sendromdan geçişli akut myelomonositik lösemi olgusunda monozomi 7 sitogenetik anomalisi
Abstract
Özet
Myelodisplastik sendrom sitopeni ile karakterize, hematopoietik kök hücrelerin klonal bir hastalığıdır. Hastalarda kemik iliğinde hücre yapılmamasına bağlı komplikasyonlardan, akut lösemiye kadar geniş bir yelpazede risk tanımlanır. Myelodisplastik sendromda ve/veya akut lösemilerde prognozu belirleyen en önemli kriterlerden biri kemik iliği örneklerinin sitogenetik incelemesidir. Burada myelodisplastik sendromdan transforme akut myelomonositik lösemi (Akut miyelositik lösemi-M4) tanısı almış bir olgu sunulmaktadır. Dişeti kanaması, halsizlik ve kilo kaybı şikayetleri ile kliniğe başvuran 57 yaşındaki erkek olguda, kanda yüksek lökosit sayısı dikkat çekmiştir. Kemik iliği analizinde olguya akut myelomonositik lösemi tanısı konmuştur. Kemik iliği sitogenetik analizinde monozomi 7 ile uyumlu karyotip örnekleri tespit edilmiş olup "kötü prognoz belirteci" olarak yorumlanmıştır. Hastada kemoterapi sürmekte olup, halen remisyon elde edilmiş durumdadır.
Anahtar sözcükler: Akut miyelomonositik lösemi, miyelodisplastik sendrom, monozomi 7, kromozomal anomali
Abstract
The myelodysplastic syndrome is a diverse group of clonal hematopoietic stem cell disorders characterized by cytopenia. Patients have a risk of developing acute leukemia though most succumb to complications of low blood counts. One of the most important criteria in myelodysplastic syndrome and/or acute leukemia which represent prognosis is the cytogenetic analyses of bone marrow. Here we presented an acute myelomonocytic leukemia case (Acute melocytic leukemia-M4) transferred from myelodysplastic syndrome. A 57 year-old male patient with gingival bleeding, fatigue, weight loss complains had high leucocyte count level. In his bone marrow analyses revealed myelomonocytic leukemia diagnosis. Monosomy 7 was observed in his bone marrow cytogenetic analyses result which was accepted as "poor prognostic criteria". The patient still has treated and is in remission phase now.
Keywords: Acute myelomonocytic leukemia, myelodysplastic syndrome, monosomy 7, chromosomal abnormality
Keywords
References
- Lichtman MA, Brennan JK. Myelodysplastic disorders (Indolent clonal myeloid diseases and oligoblastic leukemia). In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, eds. Williams Hematology. 6th ed. New York:McGraw-Hill, 2001: 1029-46.
- Redner A. Leukemias. In: Lanzkowsky P, ed. Manual of Pediatric Hematology and Oncology. 4th edition. San Diego: Elsevier Academic Press; 2005; pp 415-52.
- Golub TR, Arceci RJ. Acute myelogenous leukemia. In: Pizzo PA, Poplack DG. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia: Lippincott Williams&Wilkins, 2006; pp 591-644.
- Heim S, Mitelman F: Cancer Cytogenetics (2.nd ed.). Wiley-Liss, New York, 1995.
- Yunis JJ. New chromosome tecniques in the study of human neoplasia. Human Pathol 1981; 1: 540-9.
- Seabright M. Improvement of tyripsin method for banding chromosomes. Lancet 1973; 1: 1249.
- Mitelman Fed CN. Quidance for cancer cytogenetics, supplement an international system for human cytogenetic nomenculature. Basel: J. Karger New York, 1991.
- Güran Ş, Bahçe M, Tunca Y, İmirzalioğlu N, Ural AU, Beyan C, Suvay S, Yalçın A. Miyelodisplastik sendrom olgularında sitogenetik analiz sonuçları. Gülhane Tıp Dergisi 2000; 42: 337-40.
- Sendi S H, Hichri H et al: Cytogenetic survey of 117 Tunisian patients with de novo myelodysplastic syndrome. Annalles de génétique 2002; 45: 131-5.
- Yulia V. Olshanskayaa, , Alla I. Udovichenkoa, Lubov Yu Kolosovaa and Alina V. Kokhnoa. Myelodysplastic syndrome with monosomy 7 in a patient with XY gonadal dysgenesis (incomplete testicular feminization) Cancer Genetics and Cytogenetics 2009:191;2: 113-4.
- Marosi C, Köller U, Koller-Weber E, Schwarzinger I, Schneider B, Jäger U, Vahls P, Nowotny H, Pirc-Danoewinata H, Steger G, et al. Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML. Cancer Genet Cytogenet 1992;6: 14-25.
- Johansson B, Mertens F, Heim S, Kristoffersson U, Mitelman F. Cytogenetics of secondary myelodysplasia (sMDS) and acute nonlymphocytic leukemia (sANLL). Eur J Haematol 1991;47: 17-27.
Miyelodisplastik sendromdan geçişli akut myelomonositik lösemi olgusunda monozomi 7 sitogenetik anomalisi
Abstract
Myelodisplastik sendrom sitopeni ile karakterize, hematopoietik kök hücrelerin klonal bir hastalığıdır. Hastalarda kemik iliğinde hücre yapılmamasına bağlı komplikasyonlardan, akut lösemiye kadar geniş bir yelpazede risk tanımlanır. Myelodisplastik sendromda ve/veya akut lösemilerde prognozu belirleyen en önemli kriterlerden biri kemik iliği örneklerinin sitogenetik incelemesidir. Burada myelodisplastik sendromdan transforme akut myelomonositik lösemi (Akut miyelositik lösemi-M4) tanısı almış bir olgu sunulmaktadır. Dişeti kanaması, halsizlik ve kilo kaybı şikayetleri ile kliniğe başvuran 57 yaşındaki erkek olguda, kanda yüksek lökosit sayısı dikkat çekmiştir. Kemik iliği analizinde olguya akut myelomonositik lösemi tanısı konmuştur. Kemik iliği sitogenetik analizinde monozomi 7 ile uyumlu karyotip örnekleri tespit edilmiş olup “kötü prognoz belirteci” olarak yorumlanmıştır. Hastada kemoterapi sürmekte olup, halen remisyon elde edilmiş durumdadır
References
- Lichtman MA, Brennan JK. Myelodysplastic disorders (Indolent clonal myeloid diseases and oligoblastic leukemia). In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U, eds. Williams Hematology. 6th ed. New York:McGraw-Hill, 2001: 1029-46.
- Redner A. Leukemias. In: Lanzkowsky P, ed. Manual of Pediatric Hematology and Oncology. 4th edition. San Diego: Elsevier Academic Press; 2005; pp 415-52.
- Golub TR, Arceci RJ. Acute myelogenous leukemia. In: Pizzo PA, Poplack DG. Principles and Practice of Pediatric Oncology. 5th ed. Philadelphia: Lippincott Williams&Wilkins, 2006; pp 591-644.
- Heim S, Mitelman F: Cancer Cytogenetics (2.nd ed.). Wiley-Liss, New York, 1995.
- Yunis JJ. New chromosome tecniques in the study of human neoplasia. Human Pathol 1981; 1: 540-9.
- Seabright M. Improvement of tyripsin method for banding chromosomes. Lancet 1973; 1: 1249.
- Mitelman Fed CN. Quidance for cancer cytogenetics, supplement an international system for human cytogenetic nomenculature. Basel: J. Karger New York, 1991.
- Güran Ş, Bahçe M, Tunca Y, İmirzalioğlu N, Ural AU, Beyan C, Suvay S, Yalçın A. Miyelodisplastik sendrom olgularında sitogenetik analiz sonuçları. Gülhane Tıp Dergisi 2000; 42: 337-40.
- Sendi S H, Hichri H et al: Cytogenetic survey of 117 Tunisian patients with de novo myelodysplastic syndrome. Annalles de génétique 2002; 45: 131-5.
- Yulia V. Olshanskayaa, , Alla I. Udovichenkoa, Lubov Yu Kolosovaa and Alina V. Kokhnoa. Myelodysplastic syndrome with monosomy 7 in a patient with XY gonadal dysgenesis (incomplete testicular feminization) Cancer Genetics and Cytogenetics 2009:191;2: 113-4.
- Marosi C, Köller U, Koller-Weber E, Schwarzinger I, Schneider B, Jäger U, Vahls P, Nowotny H, Pirc-Danoewinata H, Steger G, et al. Prognostic impact of karyotype and immunologic phenotype in 125 adult patients with de novo AML. Cancer Genet Cytogenet 1992;6: 14-25.
- Johansson B, Mertens F, Heim S, Kristoffersson U, Mitelman F. Cytogenetics of secondary myelodysplasia (sMDS) and acute nonlymphocytic leukemia (sANLL). Eur J Haematol 1991;47: 17-27.
Details
| Primary Language | English |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | June 29, 2009 |
| Published in Issue | Year 2009Volume: 31 Issue: 3 |