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Pulmonary alveolar microlithiasis: quantitative approach by bone scintigraphy

Year 2009, Volume: 31 Issue: 4, 481 - 486, 27.10.2009

Abstract

Abstract

Pulmonary alveolar microlithiasis (PAM) is a rare idiopathic disease of unknown etiology and pathogenesis. PAM is characterized histopathologically by extensive intra-alveolar calcium and phosphate deposition throughout both lung parenchymas. None-invasive diagnosis of pulmonary calcification and ossification requires various imaging techniques, including chest radiography and computed tomography, while bone scintigraphy may play a role in the disease staging by quantitative analysis. In this report, we presented a quantitative assessment technique for calcified foci in lungs by means of relative density analysis in successive bone scintigraphies of a patient with PAM.

Keywords: Pulmonary alveolar microlithiasis, bone scintigraphy, density, computed tomography.

 

Özet

Pulmoner alveolar mikrolitiyazis (PAM) etiyoloji ve patogenezi bilinmeyen nadir idiopatik bir hastalıktır. Histopatolojik olarak her iki akciğer parankiminde yaygın intra-alveolar kalsiyum ve fosfat çökmesi ile karakterizedir. Pulmoner kalsifikasyon ve ossifkasyonun non-invaziv tanısı direkt akciğer grafisi, bilgisayarlı tomografi gibi görüntüleme tekniklerini gerektirirken, kemik sintigrafisi de kantitatif analiz ile hastalığın düzeyi hakkında bilgi vererek rol alabilir. Bu raporda, bir PAM hastasının bir birini takip eden kemik sintigrafilerinde rölatif dansite analizi ile akciğerlerdeki kalsifiye odakların kantitatif olarak değerlendirildiği bir yöntem sunuldu.

Anahtar sözcükler: Pulmoner alveolar mikrolitiyasis, kemik sintigrafisi, dansite, bilgisayarlı tomografi

References

  • Senyigit A, Yaramis A, Gürkan F, Kirbas G, Buyukbayram H, Nazaroglu H, Alp M.N, Topcu F. Pulmonary alveolar microlithiasis: A rare familial inheritance with report of six cases in a family. Respiration 2001; 68:204-9.
  • Chan E.D, Morales D.V, Welsh C.H, McDermott M.T, Schwarz M.I. Calcium Deposition with or without Bone Formation in the Lung. Am J Respir Crit Care Med 2002; 165: 1654-69.
  • Lauta VM. Pulmonary alveolar microlithiasis: an overview of clinical and pathological features together with possible therapies. Respir Med 2003; 97: 1081-5.
  • Mariotta S, Ricci A, Papale M, De Clementi F, Sposato B, Guidi F, et al. Pulmonary alveolar microlithiasis: report on 576 cases published in the literature. Sarcoidosis Vasc Diffuse Lung Dis 2004; 21: 73–181.
  • Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, et al. Mutations SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. Am J Hum Genet 2006; 79: 650–6.
  • Mariotta S, Guidi L, Papale M, Ricci A, Bisetti A, Pulmonary alveolar microlithiasis: Review of Italian reports. Eur J Epidemiol 1997; 13: 587-90.
  • Castellana G, Gentile M, Castellana R, Fiorente P, Lamorgese V. Pulmonary Alveolar Microlithiasis: Clinical Features, Evolution of the Phenotype, and Review of the Literature. Am J Med Genet 2002; 111: 220-4.
  • Castellana G, Lamorgese V. Pulmonary Alveolar Microlithiasis. World Cases and Review of the Literature. Respiration 2003; 70: 549-55.
  • Gasparetto E.L, Tazoniero P, Escuissato D.L, Marchiori E, Frare E Silva R.L, Sakamoto D. Pulmonary alveolar microlithiasis presenting with crazy-paving pattern on high resolution CT. Brit J Radiol 2004; 77; 974-6.
  • Ucan ES, Keyf AI, Aydilek R, Yalcin Z, Sebit S, Kudu M, Ok U. Pulmonary alveolar microlithiasis: review of Turkish reports. Thorax 1993; 48; 171-3.
  • Chung MJ, Lee KS, Franquet T, Müller NL, Han J, Kwon OJ. Metabolic lung disease; imaging and histopathologic findings. Eur J Radiol 2005; 54: 233-45.
  • Coolens JL, Devos P, De Roo M. Diffuse pulmonary uptake of 99mTc bone-imaging agents: case report and survey. Eur J Nucl Med. 1985; 11: 36-42.
  • Deniz O, Ors F, Tozkoparan E, Ozcan A, Gumus S, Bozlar U, Bilgic H, Ekiz K, Demirci N. High resolution computed tomographic features of pulmonary alveolar microlithiasis. Eur J Radiol 2005; 55: 452-60.
  • Rossi SE, Erasmus JJ, Volpacchio M, Franquet T, Castiglioni T, McAdams HP. "Crazy- paving" pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics. 2003; 23: 1509-19.
  • Shah TC, Talwar A, Shah RD, Margouleff D. Pulmonary alveolar microlithiasis: radiographic and scintigraphic correlation. Clin Nucl Med. 2007; 32:249-251.
  • Sahin U, Yildiz M, Bircan H.A, Akaya A, Candir O. Absence of pulmonary uptake of Tc- 99m methylendiphosphonate in alveolar microlithiasis. Ann Nucl Med 2004; 18: 695-8.
  • Turktas H, Ozturk C, Guven M, Ugur P, Erzen C. Pulmonary alveolar microlithiasis with the absence of technethium-99m MDP uptake of lungs. Clin Nucl Med 1988; 13: 883-5.
  • Shigeno C, Fukunaga M, Morita R, Maeda H, Hino M, Torizuka K. Bone scintigraphy in pulmonary alveolar microlithiasis: a comparative study of radioactivity and density distribution. Clin Nucl Med 1982; 7: 103-7.

Pulmoner alveolar mikrolitiyazis: kemik sintigrafisi ile kantitatif yaklaşım

Year 2009, Volume: 31 Issue: 4, 481 - 486, 27.10.2009

Abstract

Pulmoner alveolar mikrolitiyazis (PAM) etiyoloji ve patogenezi bilinmeyen nadir idiopatik bir hastalıktır. Histopatolojik olarak her iki akciğer parankiminde yaygın intra-alveolar kalsiyum ve fosfat çökmesi ile karakterizedir. Pulmoner kalsifikasyon ve ossifkasyonun non-invaziv tanısı direkt akciğer grafisi, bilgisayarlı tomografi gibi görüntüleme tekniklerini gerektirirken, kemik sintigrafisi de kantitatif analiz ile hastalığın düzeyi hakkında bilgi vererek rol alabilir. Bu raporda, bir PAM hastasının bir birini takip eden kemik sintigrafilerinde rölatif dansite analizi ile akciğerlerdeki kalsifiye odakların kantitatif olarak değerlendirildiği bir yöntem sunuldu

References

  • Senyigit A, Yaramis A, Gürkan F, Kirbas G, Buyukbayram H, Nazaroglu H, Alp M.N, Topcu F. Pulmonary alveolar microlithiasis: A rare familial inheritance with report of six cases in a family. Respiration 2001; 68:204-9.
  • Chan E.D, Morales D.V, Welsh C.H, McDermott M.T, Schwarz M.I. Calcium Deposition with or without Bone Formation in the Lung. Am J Respir Crit Care Med 2002; 165: 1654-69.
  • Lauta VM. Pulmonary alveolar microlithiasis: an overview of clinical and pathological features together with possible therapies. Respir Med 2003; 97: 1081-5.
  • Mariotta S, Ricci A, Papale M, De Clementi F, Sposato B, Guidi F, et al. Pulmonary alveolar microlithiasis: report on 576 cases published in the literature. Sarcoidosis Vasc Diffuse Lung Dis 2004; 21: 73–181.
  • Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, et al. Mutations SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. Am J Hum Genet 2006; 79: 650–6.
  • Mariotta S, Guidi L, Papale M, Ricci A, Bisetti A, Pulmonary alveolar microlithiasis: Review of Italian reports. Eur J Epidemiol 1997; 13: 587-90.
  • Castellana G, Gentile M, Castellana R, Fiorente P, Lamorgese V. Pulmonary Alveolar Microlithiasis: Clinical Features, Evolution of the Phenotype, and Review of the Literature. Am J Med Genet 2002; 111: 220-4.
  • Castellana G, Lamorgese V. Pulmonary Alveolar Microlithiasis. World Cases and Review of the Literature. Respiration 2003; 70: 549-55.
  • Gasparetto E.L, Tazoniero P, Escuissato D.L, Marchiori E, Frare E Silva R.L, Sakamoto D. Pulmonary alveolar microlithiasis presenting with crazy-paving pattern on high resolution CT. Brit J Radiol 2004; 77; 974-6.
  • Ucan ES, Keyf AI, Aydilek R, Yalcin Z, Sebit S, Kudu M, Ok U. Pulmonary alveolar microlithiasis: review of Turkish reports. Thorax 1993; 48; 171-3.
  • Chung MJ, Lee KS, Franquet T, Müller NL, Han J, Kwon OJ. Metabolic lung disease; imaging and histopathologic findings. Eur J Radiol 2005; 54: 233-45.
  • Coolens JL, Devos P, De Roo M. Diffuse pulmonary uptake of 99mTc bone-imaging agents: case report and survey. Eur J Nucl Med. 1985; 11: 36-42.
  • Deniz O, Ors F, Tozkoparan E, Ozcan A, Gumus S, Bozlar U, Bilgic H, Ekiz K, Demirci N. High resolution computed tomographic features of pulmonary alveolar microlithiasis. Eur J Radiol 2005; 55: 452-60.
  • Rossi SE, Erasmus JJ, Volpacchio M, Franquet T, Castiglioni T, McAdams HP. "Crazy- paving" pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics. 2003; 23: 1509-19.
  • Shah TC, Talwar A, Shah RD, Margouleff D. Pulmonary alveolar microlithiasis: radiographic and scintigraphic correlation. Clin Nucl Med. 2007; 32:249-251.
  • Sahin U, Yildiz M, Bircan H.A, Akaya A, Candir O. Absence of pulmonary uptake of Tc- 99m methylendiphosphonate in alveolar microlithiasis. Ann Nucl Med 2004; 18: 695-8.
  • Turktas H, Ozturk C, Guven M, Ugur P, Erzen C. Pulmonary alveolar microlithiasis with the absence of technethium-99m MDP uptake of lungs. Clin Nucl Med 1988; 13: 883-5.
  • Shigeno C, Fukunaga M, Morita R, Maeda H, Hino M, Torizuka K. Bone scintigraphy in pulmonary alveolar microlithiasis: a comparative study of radioactivity and density distribution. Clin Nucl Med 1982; 7: 103-7.
There are 18 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Taner Erselcan

Serdar Gül

Zekiye Hasbek

Hulusi Eğilmez

Cesur Gümüş

Publication Date October 27, 2009
Published in Issue Year 2009Volume: 31 Issue: 4

Cite

AMA Erselcan T, Gül S, Hasbek Z, Eğilmez H, Gümüş C. Pulmonary alveolar microlithiasis: quantitative approach by bone scintigraphy. CMJ. December 2009;31(4):481-486.