Metastasis to bone from gastric cancer: a single centre experience

Saadettin Kılıçkap; Ümit Tapan; Şuayib Yalçın

Metastasis to bone from gastric cancer: a single centre experience

Year 2010, Volume: 32 Issue: 2, 192 - 198, 11.06.2010

Saadettin Kılıçkap , Ümit Tapan , Şuayib Yalçın

Abstract

Abstract

Aim. Bone metastasis is relatively uncommon with gastric carcinoma. Its complications have a negative impact on the quality of life and function of cancer patients. We planned a retrospective study to investigate the incidence and clinicopathological features of bone metastasis form gastric cancer and to explore the therapeutic outcome. Method. We retrospectively reviewed the clinical records of consecutive 253 patients with gastric cancer who admitted Outpatient Clinic of Medical Oncology in Hacettepe University. Result. Of 253 patients with gastric cancer, 26 patients (10.2%) were found to have skeletal metastases. The median age was 56 years. The vertebrae were the most frequent metastatic site (85%). Bone metastasis-related events (BMEs) included fracture, cord compression, severe bone pain, and radiation therapy because of the risk of fracture were found in 15 (58%) patients. Surgical treatment was given to 3 patients because of bone fracture and cord compression. The median survival was 130 days and 1-year survival was 27%. The median duration between diagnosis of skeletal metastasis and death was 68 days. Elevated alkaline phosphatase (ALP) level was associated with short survival. Conclusion. Skeletal metastasis-associated complications may significantly reduce the quality of life. Bone metastasis is a major health problem because of its complications including pain, pathologic bone fractures, and spinal cord compression.

Key words: Gastric cancer; bone metastasis; incidence; survival; complication.

Özet

Amaç. Mide kanserinde kemik metastazı sık değildir. Kemik metastazı komplikasyonları kanser hastalarında fonksiyon ve yaşam kalitesi üzerine olumsuz etkiler yapmaktadır. Çalışmada mide kanseri olgularında kemik metastazı insidansı, klinikopatolojik özellikleri ve tedavi sonuçlarını değerlendirmeyi amaçladık. Yöntem. Hacettepe Üniversitesi Medikal Onkoloji polikliniğine başvuran 253 hastanın klinik kayıtları retrospektif olarak gözden geçirildi. Bulgular. Mide kanserli 253 hastanın 26’sında (%10.2) kemik metastazı bulundu. Ortanca yaş 56 idi. Vertebralar en sık metastaz yeri idi (%85). Fraktür, kord basısı, ciddi kemik ağrısı ve fraktür riski nedeniyle radyoterapi uygulaması gibi kemik metastazı ilişkili olaylar 15 (%58) olguda izlendi. 3 hastaya kord basısı ve kemik fraktürü nedeniyle cerrahi yapıldı. Ortanca sağkalım 130 gün ve 1 yıllık sağkalım %27 idi. Kemik metastazından ölüme kadar geçen ortanca sure 68 gün idi. Yüksek alkalen fosfataz (ALP) düzeyi kısa sağkalımla ilişkili idi. Sonuç. İskelet metastazına bağlı komplikasyonlar yaşam kalitesini anlamlı derecede azaltabilir. Kemik metastazları, ağrı, patolojik kemik kırıkları ve spinal kord bası komplikasyonları nedeniyle önemli bir sağlık sorunudur.

Anahtar kelimeler: Mide kanseri; kemik metastazı; insidans; sağkalım; komplikasyon.

Keywords

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