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Granular cell tumor of the esophagus

Year 2011, Volume: 33 Issue: 4, 473 - 477, 17.01.2011

Mete Akın Mehmet İşler Gökhan Aksakal Nermin Karahan Yıldıran Songür

Abstract

Abstract

Granular cell tumors are rare lesions and only 4-6% of cases were located in gastrointestinal system. Approximately one third of these cases occur in the esophagus. They are usually small and asymptomatic lesions and malignancy rate is approximately 2-4%. They are usually detected incidentally, however may be cause some nonspesific symptoms in patients. Altough endoscopic follow up is sufficient for small and asymptomatic tumors, surgical or endoscopic resection is recommended in symptomatic patients and lesions with malign potential. We report here in, a case of granular cell tumor, wich was detected in distal esophagus on upper gastrointestinal tract endoscopy and resected by endoscopic polipectomy, in a patient with nonspesific dyspeptic complaints.

Keywords: Granular cell tumor, esophagus, endoscopic polypectomy

 

Özet

Granüler hücreli tümörler nadir lezyonlardır ve vakaların sadece % 4-6’sı gastrointestinal sistemde lokalize olur. Bunlarında yaklaşık üçte biri özofagusta ortaya çıkar. Genellikle küçük ve asemptomatik lezyonlardır ve malignite oranları yaklaşık %2-4 arasındadır. Genellikle tesadüfen saptanırlar ancak bazı nonspesifik semptomalara da sebep olabilirler. Küçük ve asemptomatik lezyonlarda endoskopik izlem yeterli olabilirken semptomatik hastalarda ve malignite potansiyeli olan lezyonlarda cerrahi veya endoskopik rezeksiyon önerilmektedir. Bu yazıda, nonspesifik dispeptik yakınmalar nedeniyle tetkik edilen, üst gastrointestinal sistem endoskopisinde distal özofagusta submukozal polipoid lezyon tespit edilerek endoskopik polipektomi ile rezeksiyon uygulanan ve granüler hücreli tümör 5 tanısı konulan bir vaka bildiriyoruz.

Anahtar sözcükler: Granüler hücreli tümör, özofagus, endoskopik polipektomi

Keywords

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References

  • Abrikossoff A. Uber Myome, ausgehend von der quergestreiften willkurlichen Muskulatur. Virchows Arch Pathol Anat 1926; 260: 215-33.
  • Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 1980; 13: 301-16.
  • M orrison JG, Gray GF Jr, Dao AH, Adkins B Jr. Granular cell tumors. Am Surg 1987; 53: 156-60.
  • Johnston MJ, Helwig EB. Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci 1981; 26: 807-16.
  • Orlowska J, Pachlewski J, Gugulski A, Butruk E. A conservative approach to granular cell tumors of the esophagus: four case reports and literature review. Am J Gastroenterol 1993; 88: 311-5.
  • Brady PG, Nord HJ, Connar RG. Granular cell tumor of the esophagus: natural history, diagnosis, and therapy. Dig Dis Sci 1988; 33: 1329-33.
  • Parfitt JR, McLean CA, Joseph MG, Streutker CJ, Al-Haddad S, Driman DK. Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients. Histopathology 2006; 48: 424-30.
  • Billeret Lebranchu V. [Granular cell tumor Epidemiology of 263 cases]. Arch Anat Cytol Pathol 1999; 47: 26-30.
  • Perçinel S, Savaş B, Yılmaz G, Erinanç H, Küpana Ayva S, Bektaş M, Ensari A. Granular cell tumor of the esophagus: three case reports and review of the lithetarure. Turk J Gastroenterol 2008; 19: 184-8.
  • Kaplan S, Dağlı AF, Özercan İH, Bahçecioğlu İH. Özofagus yerleşimli granüler hücreli tümör: Olgu sunumu. F.Ü. Sağlık Bil. Dergisi 2004: 18; 247-49.
  • David O, Jakate S. Multifocal granular cell tumor of the esophagus and proximal stomach with infiltrative pattern: a case report and review of the literature. Arch Pathol Lab Med 1999; 123: 967-73.
  • Ordonez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol 1999; 23: 207-22.
  • Mazur M, Shultz JJ, Myers JL. Granular cell tumor: immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med 1990; 114: 692-6.
  • Narra SL, Tombazzi C, Datta V, Ismail MK. Granular cell tumor of the esophagus: report of five cases and review of the litherature. Am J Med Sci 2008; 335: 338-41.
  • De Rezende L, Lucendo AJ, Alvarez-Argüelles H. Granular cell tumors of the esophagus: report of five cases and review of diagnostic and therapeutic techniques. Dis Esophagus 2007; 20: 436-43.
  • Ordonez NG. Granular cell tumor: a review and update. Adv Anat Pathol 1999; 6: 186-203.
  • Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: 779-94.
  • Klima M, Peters J. Malignant granular cell tumor. Arch Pathol Lab Med 1987; 111: 1070-3.
  • Jardines L, Cheung L, LiVolsi V, Hendrickson S, Brooks JJ. Malignant granular cell tumors: report of a case and review of the literature. Surgery 1994; 116: 49- 54.
  • Giacobbe A, Facciorusso D, Conoscitore P, Spirito F, Squillante MM, Bisceglia M. Granular cell tumor of the esophagus. Am J Gastroenterol 1988; 83: 1398- 400.
  • Brandimarte G, Tursi A, Vittori I, Monardo E. Granular cell tumour of the oesophagus: a rare cause of dysphagia with differential diagnosis of oesophageal neoplastic lesions. Digest Liver Dis 2000; 32: 803-6.
  • Tada S, Iida M, Yao T, Miyagahara T, Hasuda S, Fujishima M. Granular cell tumor of the esophagus: endoscopic ultrasonographic demonstration and endoscopic removal. Am J Gastroenterol 1990; 85: 1507-11.
  • Yasuda I, Tomita E, Nagura K, Nishigaki Y, Yamada O, Kachi H. Endoscopic removal of granular cell tumors. Gastrointest Endosc 1995;41:163-7
  • Fotiadis C, Manolis EN, Troupis TG, Gorgoulis VG, Sechas MN. Endoscopic resection of a large granular cell tumor of the esophagus. J Surg Oncol 2000; 75: 277-9.
  • Norberto L, Urso E, Angriman I, Ranzato R, Erroi F, Marino S, Tosato S, Ruffolo C, D'Amico DF. Yttrium-aluminum-garnet laser therapy of esophageal granular cell tumor. Surg Endosc 2002; 16: 361-2.
  • Maccarini MR, Michieletti G, Tampieri I, Triossi O, Bertinelli E, Casetti T. Simple endoscopic treatment of a granular-cell tumor of the esophagus. Endoscopy 1996; 28: 730-1.

Özofagus yerleşimli granüler hücreli tümör

Year 2011, Volume: 33 Issue: 4, 473 - 477, 17.01.2011

Mete Akın Mehmet İşler Gökhan Aksakal Nermin Karahan Yıldıran Songür

Abstract

Granüler hücreli tümörler nadir lezyonlardır ve vakaların sadece % 4-6’sı gastrointestinal sistemde lokalize olur. Bunlarında yaklaşık üçte biri özofagusta ortaya çıkar. Genellikle küçük ve asemptomatik lezyonlardır ve malignite oranları yaklaşık %2-4 arasındadır. Genellikle tesadüfen saptanırlar ancak bazı nonspesifik semptomalara da sebep olabilirler. Küçük ve asemptomatik lezyonlarda endoskopik izlem yeterli olabilirken semptomatik hastalarda ve malignite potansiyeli olan lezyonlarda cerrahi veya endoskopik rezeksiyon önerilmektedir. Bu yazıda, nonspesifik dispeptik yakınmalar nedeniyle tetkik edilen, üst gastrointestinal sistem endoskopisinde distal özofagusta submukozal polipoid lezyon tespit edilerek endoskopik polipektomi ile rezeksiyon uygulanan ve granüler hücreli tümör 5 tanısı konulan bir vaka bildiriyoruz.

Anahtar sözcükler: Granüler hücreli tümör, özofagus, endoskopik polipektomi

Keywords

Granüler hücreli tümör özofagus endoskopik polipektomi

References

  • Abrikossoff A. Uber Myome, ausgehend von der quergestreiften willkurlichen Muskulatur. Virchows Arch Pathol Anat 1926; 260: 215-33.
  • Lack EE, Worsham GF, Callihan MD, Crawford BE, Klappenbach S, Rowden G, Chun B. Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 1980; 13: 301-16.
  • M orrison JG, Gray GF Jr, Dao AH, Adkins B Jr. Granular cell tumors. Am Surg 1987; 53: 156-60.
  • Johnston MJ, Helwig EB. Granular cell tumors of the gastrointestinal tract and perianal region: a study of 74 cases. Dig Dis Sci 1981; 26: 807-16.
  • Orlowska J, Pachlewski J, Gugulski A, Butruk E. A conservative approach to granular cell tumors of the esophagus: four case reports and literature review. Am J Gastroenterol 1993; 88: 311-5.
  • Brady PG, Nord HJ, Connar RG. Granular cell tumor of the esophagus: natural history, diagnosis, and therapy. Dig Dis Sci 1988; 33: 1329-33.
  • Parfitt JR, McLean CA, Joseph MG, Streutker CJ, Al-Haddad S, Driman DK. Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients. Histopathology 2006; 48: 424-30.
  • Billeret Lebranchu V. [Granular cell tumor Epidemiology of 263 cases]. Arch Anat Cytol Pathol 1999; 47: 26-30.
  • Perçinel S, Savaş B, Yılmaz G, Erinanç H, Küpana Ayva S, Bektaş M, Ensari A. Granular cell tumor of the esophagus: three case reports and review of the lithetarure. Turk J Gastroenterol 2008; 19: 184-8.
  • Kaplan S, Dağlı AF, Özercan İH, Bahçecioğlu İH. Özofagus yerleşimli granüler hücreli tümör: Olgu sunumu. F.Ü. Sağlık Bil. Dergisi 2004: 18; 247-49.
  • David O, Jakate S. Multifocal granular cell tumor of the esophagus and proximal stomach with infiltrative pattern: a case report and review of the literature. Arch Pathol Lab Med 1999; 123: 967-73.
  • Ordonez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol 1999; 23: 207-22.
  • Mazur M, Shultz JJ, Myers JL. Granular cell tumor: immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med 1990; 114: 692-6.
  • Narra SL, Tombazzi C, Datta V, Ismail MK. Granular cell tumor of the esophagus: report of five cases and review of the litherature. Am J Med Sci 2008; 335: 338-41.
  • De Rezende L, Lucendo AJ, Alvarez-Argüelles H. Granular cell tumors of the esophagus: report of five cases and review of diagnostic and therapeutic techniques. Dis Esophagus 2007; 20: 436-43.
  • Ordonez NG. Granular cell tumor: a review and update. Adv Anat Pathol 1999; 6: 186-203.
  • Fanburg-Smith JC, Meis-Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: 779-94.
  • Klima M, Peters J. Malignant granular cell tumor. Arch Pathol Lab Med 1987; 111: 1070-3.
  • Jardines L, Cheung L, LiVolsi V, Hendrickson S, Brooks JJ. Malignant granular cell tumors: report of a case and review of the literature. Surgery 1994; 116: 49- 54.
  • Giacobbe A, Facciorusso D, Conoscitore P, Spirito F, Squillante MM, Bisceglia M. Granular cell tumor of the esophagus. Am J Gastroenterol 1988; 83: 1398- 400.
  • Brandimarte G, Tursi A, Vittori I, Monardo E. Granular cell tumour of the oesophagus: a rare cause of dysphagia with differential diagnosis of oesophageal neoplastic lesions. Digest Liver Dis 2000; 32: 803-6.
  • Tada S, Iida M, Yao T, Miyagahara T, Hasuda S, Fujishima M. Granular cell tumor of the esophagus: endoscopic ultrasonographic demonstration and endoscopic removal. Am J Gastroenterol 1990; 85: 1507-11.
  • Yasuda I, Tomita E, Nagura K, Nishigaki Y, Yamada O, Kachi H. Endoscopic removal of granular cell tumors. Gastrointest Endosc 1995;41:163-7
  • Fotiadis C, Manolis EN, Troupis TG, Gorgoulis VG, Sechas MN. Endoscopic resection of a large granular cell tumor of the esophagus. J Surg Oncol 2000; 75: 277-9.
  • Norberto L, Urso E, Angriman I, Ranzato R, Erroi F, Marino S, Tosato S, Ruffolo C, D'Amico DF. Yttrium-aluminum-garnet laser therapy of esophageal granular cell tumor. Surg Endosc 2002; 16: 361-2.
  • Maccarini MR, Michieletti G, Tampieri I, Triossi O, Bertinelli E, Casetti T. Simple endoscopic treatment of a granular-cell tumor of the esophagus. Endoscopy 1996; 28: 730-1.
There are 26 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Mete Akın

Mehmet İşler

Gökhan Aksakal

Nermin Karahan

Yıldıran Songür

Publication Date January 17, 2011
Published in Issue Year 2011Volume: 33 Issue: 4

Cite

AMA Akın M, İşler M, Aksakal G, Karahan N, Songür Y. Granular cell tumor of the esophagus. CMJ. December 2011;33(4):473-477.