An aggressive Basal Cell Carcinoma with multiple focuses and distant lung metastasis: case report

Volume: 34 Number: 4 April 7, 2012
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An aggressive Basal Cell Carcinoma with multiple focuses and distant lung metastasis: case report

Abstract

Abstract

Basal cell carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate from the basal layer of the epidermis and it is the most common type of skin cancer in humans. Giant BCC (i.e. greater than 5 cm in diameter) is quite rare and comprises 0.5 percent of all BCC. Despite the high incidence of BCC, metastasis of this tumor is rare, with rates ranging from 0.0028% to 0.55% of all BCC cases. In this case, the tumour reached a giant size and had a pulmonary metastasis.,We aimed to emphasize that although BCC’s are usually indolent; the importance of adequate surgery and chemoradiotherapy should always be considered in indicated cases.

Keywords: Basal cell carcinoma, metastasis, giant size, adequate surgery

Özet

Bazal hücreli karsinom (BHK) epidermisin bazal tabakasından kaynaklanan ve nonkeratinize hücrelerden oluşan en yaygın cilt tümörüdür. Dev BHK (yani çapı 5 cm’den büyük) oldukça nadirdir ve tüm BHK’ların %0,5’ ini oluşturmaktadır. BHK insidansı yüksek olmasına rağmen, bu tümörün metastaz oranı tüm vakaların %0,0028-%0,55 arasında değişmektedir. Bu vakada tümör dev boyuta ulaştı ve akciğer metastazı vardı. Burada, BHK’lar genellikle yavaş seyirli olmasına rağmen gerekli vakalarda yeterli cerrahi ve kemoradyoterapinin önemini vurgulamak istedik.

Anahtar sözcükler: Bazal hücreli karsinom, metastaz, dev çap, yeterli cerrahi

Keywords

References

  1. Weedon D. Tumors of epidermis. In Tumors of Weedon's Skin Pathology. 3rd ed. Weedon D (Eds). New Yolk: Churchill-Livingstone Elsevier; 2010: 682-3.
  2. Leboit PE, Burg G, Weedon D, Sarasin A. ed. World Health Organization Classification Of Tumours Pathology & Genetics Skin Tumours, Lyon,2006
  3. Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF. Lever's Histopathology of the Skin. 9th ed. Philadelphia, PA: Lippincott Williams and Wilkins 2005: 836-49.
  4. de Bree E, Laliotis A, Manios A, Tsiftsis DD, Melissas J. Super giant basal cell carcinoma of the abdominal wall: still possible in the 21st century. Int J Dermatol 2010; 49: 806-9.
  5. Seo SH, Shim WH, Shin DH, Kim YS, Sung HW. Pulmonary metastasis of Basal cell carcinoma. Ann Dermatol 2011; 23: 213-6.
  6. Ko CB, Walton S, Keczkes K. Extensive and fatal basal cell carcinoma: a report of three cases. Br J Dermatol 1992; 127: 164-7.
  7. Mikhail GR, Nims LP, Kelly AP Jr, Ditmars DM Jr, Eyler WR. Metastatic basal cell carcinoma: review, pathogenesis, and report of two cases. Arch Dermatol 1977; 113: 1261-9.
  8. Barbaud A, Simon M, Parache RM, Serre G. Immunohistochemical characterization of the differentiation state of basal cell carcinomas with special interest for infiltrating relapsing tumors. Eur J Dermatol 1998; 8: 320-4. 9. Bozikov K, Taggart I. Metastatic infiltrative/morpheaform subtype a risk factor? Eur J Dermatol 2006; 16: 691-2. basal cell carcinoma: is

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Nilüfer Kadıoğlu

Ali Uzunlar

Murat Oktay

Cem Şahiner

Derya Özçelik

Hakan Turan

Publication Date

April 7, 2012

Submission Date

April 7, 2012

Acceptance Date

-

Published in Issue

Year 1970 Volume: 34 Number: 4

AMA
1.Erdem H, Kadıoğlu N, Uzunlar A, et al. An aggressive Basal Cell Carcinoma with multiple focuses and distant lung metastasis: case report. CMJ. 2012;34(4):510-515. https://izlik.org/JA94DJ68JP