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An aggressive Basal Cell Carcinoma with multiple focuses and distant lung metastasis: case report

Year 2012, Volume: 34 Issue: 4, 510 - 515, 07.04.2012

Havva Erdem , Nilüfer Kadıoğlu Ali Uzunlar Ümran Yıldırım , Murat Oktay Cem Şahiner Derya Özçelik Hakan Turan

Abstract

Abstract

Basal cell carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate from the basal layer of the epidermis and it is the most common type of skin cancer in humans. Giant BCC (i.e. greater than 5 cm in diameter) is quite rare and comprises 0.5 percent of all BCC. Despite the high incidence of BCC, metastasis of this tumor is rare, with rates ranging from 0.0028% to 0.55% of all BCC cases. In this case, the tumour reached a giant size and had a pulmonary metastasis.,We aimed to emphasize that although BCC’s are usually indolent; the importance of adequate surgery and chemoradiotherapy should always be considered in indicated cases.

Keywords: Basal cell carcinoma, metastasis, giant size, adequate surgery

Özet

Bazal hücreli karsinom (BHK) epidermisin bazal tabakasından kaynaklanan ve nonkeratinize hücrelerden oluşan en yaygın cilt tümörüdür. Dev BHK (yani çapı 5 cm’den büyük) oldukça nadirdir ve tüm BHK’ların %0,5’ ini oluşturmaktadır. BHK insidansı yüksek olmasına rağmen, bu tümörün metastaz oranı tüm vakaların %0,0028-%0,55 arasında değişmektedir. Bu vakada tümör dev boyuta ulaştı ve akciğer metastazı vardı. Burada, BHK’lar genellikle yavaş seyirli olmasına rağmen gerekli vakalarda yeterli cerrahi ve kemoradyoterapinin önemini vurgulamak istedik.

Anahtar sözcükler: Bazal hücreli karsinom, metastaz, dev çap, yeterli cerrahi

Keywords

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References

  • Weedon D. Tumors of epidermis. In Tumors of Weedon's Skin Pathology. 3rd ed. Weedon D (Eds). New Yolk: Churchill-Livingstone Elsevier; 2010: 682-3.
  • Leboit PE, Burg G, Weedon D, Sarasin A. ed. World Health Organization Classification Of Tumours Pathology & Genetics Skin Tumours, Lyon,2006
  • Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF. Lever's Histopathology of the Skin. 9th ed. Philadelphia, PA: Lippincott Williams and Wilkins 2005: 836-49.
  • de Bree E, Laliotis A, Manios A, Tsiftsis DD, Melissas J. Super giant basal cell carcinoma of the abdominal wall: still possible in the 21st century. Int J Dermatol 2010; 49: 806-9.
  • Seo SH, Shim WH, Shin DH, Kim YS, Sung HW. Pulmonary metastasis of Basal cell carcinoma. Ann Dermatol 2011; 23: 213-6.
  • Ko CB, Walton S, Keczkes K. Extensive and fatal basal cell carcinoma: a report of three cases. Br J Dermatol 1992; 127: 164-7.
  • Mikhail GR, Nims LP, Kelly AP Jr, Ditmars DM Jr, Eyler WR. Metastatic basal cell carcinoma: review, pathogenesis, and report of two cases. Arch Dermatol 1977; 113: 1261-9.
  • Barbaud A, Simon M, Parache RM, Serre G. Immunohistochemical characterization of the differentiation state of basal cell carcinomas with special interest for infiltrating relapsing tumors. Eur J Dermatol 1998; 8: 320-4. 9. Bozikov K, Taggart I. Metastatic infiltrative/morpheaform subtype a risk factor? Eur J Dermatol 2006; 16: 691-2. basal cell carcinoma: is
  • Weedon D. Tumors of epidermis. In Tumors of Weedon's Skin Pathology. 3rd ed. Weedon D (Eds). New Yolk: Churchill-Livingstone Elsevier; 2010: 690-1.
  • Ten Seldan R, Helwig R. Types histologiques des tumeurs cutanées. In: Ten Seldan R, Helwig R (Eds). Classification histologique internationale des tumeurs. Genève: WHO Inc 1975: 49-50.
  • Ozgediz D, Smith EB, Zheng J, Otero J, Tabatabai ZL, Corvera CU. Basal cell carcinoma does metastasize. Dermatol Online J 2008; 14: 5.
  • Rigel DS, Robins P, Friedman RJ. Predicting recurrence of basal-cell carcinomas treated by microscopically controlled excision: A recurrence index score. J Dermatol Surg Oncol 1981; 7: 807-10.
  • Gropper AB, Girouard SD, Hojman LP, Huang SJ, Qian X, Murphy GF, Vleugels RA. Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature. J Cutan Pathol 2012; 39: 526-34.
  • Rowe DE, Carroll RJ, Day CL Jr. Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. J Dermatol Surg Oncol 1989; 15: 315-28.
  • Hauben DJ, Zirkin H, Mahler D, Sacks M. The biologic behavior of basal cell carcinoma: analysis of recurrence in excised basal cell carcinoma: Part II. Plast Reconstr Surg 1982; 69: 110-6.
  • Dixon AY, Lee SH, McGregor DH.Factors predictive of recurrence of basal cell carcinoma. Am J Dermatopathol 1989; 11: 222-32.
  • Dixon AY, Lee SH, McGregor DH. Histologic features predictive of basal cell carcinoma recurrence: Results of a multivariate analysis. J Cutan Pathol 1993; 20: 137-42.
  • Chakrabarty A, Geisse JK. Medical therapies for non-melanoma skin cancer. Clin Dermatol 2004; 22: 183-8.
  • Gibbs P, Gonzalez R, Lee LA, Walsh P. Medical management of cutaneous malignancies. Clin Dermatol 2001; 19: 298-304.
  • Seegenschmiedt MH, Oberste-Beulmann S, Lang E, Lang B, Guntrum F, Olschewski T. Radiotherapy for basal cell carcinoma. Local control and cosmetic outcome. Strahlenther Onkol 2001; 177: 240-6.
  • Kwan W, Wilson D, Moravan V. Radiotherapy for locally advanced basal cell and squamous cell carcinomas of the skin. Int J Radiat Oncol Biol Phys 2004; 60: 406-11.
  • Varga E, Korom I, Raskó Z, Kis E, Varga J, Oláh J, Kemény L. Neglected Basal cell carcinomas in the 21st century. J Skin Cancer 2011; 2011: 392151.
  • Heo YS, Yoon JH, Choi JE, Ahn HH, Kye YC, Seo SH A case of superficial giant Basal cell carcinoma with satellite lesions on scalp. Ann Dermatol 2011; 23: S111-5.

Multipl odaklı, agresif davranışlı ve uzak metastaz içeren Bazal Hücreli Karsinom

Year 2012, Volume: 34 Issue: 4, 510 - 515, 07.04.2012

Havva Erdem , Nilüfer Kadıoğlu Ali Uzunlar Ümran Yıldırım , Murat Oktay Cem Şahiner Derya Özçelik Hakan Turan

Abstract

Bazal hücreli karsinom (BHK) epidermisin bazal tabakasından kaynaklanan ve nonkeratinize hücrelerden oluşan en yaygın cilt tümörüdür. Dev BHK (yani çapı 5 cm’den büyük) oldukça nadirdir ve tüm BHK’ların %0,5’ ini oluşturmaktadır. BHK insidansı yüksek olmasına rağmen, bu tümörün metastaz oranı tüm vakaların %0,0028-%0,55 arasında değişmektedir. Bu vakada tümör dev boyuta ulaştı ve akciğer metastazı vardı. Burada, BHK’lar genellikle yavaş seyirli olmasına rağmen gerekli vakalarda yeterli cerrahi ve kemoradyoterapinin önemini vurgulamak istedik

Keywords

Bazal hücreli karsinom metastaz dev çap yeterli cerrahi

References

  • Weedon D. Tumors of epidermis. In Tumors of Weedon's Skin Pathology. 3rd ed. Weedon D (Eds). New Yolk: Churchill-Livingstone Elsevier; 2010: 682-3.
  • Leboit PE, Burg G, Weedon D, Sarasin A. ed. World Health Organization Classification Of Tumours Pathology & Genetics Skin Tumours, Lyon,2006
  • Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF. Lever's Histopathology of the Skin. 9th ed. Philadelphia, PA: Lippincott Williams and Wilkins 2005: 836-49.
  • de Bree E, Laliotis A, Manios A, Tsiftsis DD, Melissas J. Super giant basal cell carcinoma of the abdominal wall: still possible in the 21st century. Int J Dermatol 2010; 49: 806-9.
  • Seo SH, Shim WH, Shin DH, Kim YS, Sung HW. Pulmonary metastasis of Basal cell carcinoma. Ann Dermatol 2011; 23: 213-6.
  • Ko CB, Walton S, Keczkes K. Extensive and fatal basal cell carcinoma: a report of three cases. Br J Dermatol 1992; 127: 164-7.
  • Mikhail GR, Nims LP, Kelly AP Jr, Ditmars DM Jr, Eyler WR. Metastatic basal cell carcinoma: review, pathogenesis, and report of two cases. Arch Dermatol 1977; 113: 1261-9.
  • Barbaud A, Simon M, Parache RM, Serre G. Immunohistochemical characterization of the differentiation state of basal cell carcinomas with special interest for infiltrating relapsing tumors. Eur J Dermatol 1998; 8: 320-4. 9. Bozikov K, Taggart I. Metastatic infiltrative/morpheaform subtype a risk factor? Eur J Dermatol 2006; 16: 691-2. basal cell carcinoma: is
  • Weedon D. Tumors of epidermis. In Tumors of Weedon's Skin Pathology. 3rd ed. Weedon D (Eds). New Yolk: Churchill-Livingstone Elsevier; 2010: 690-1.
  • Ten Seldan R, Helwig R. Types histologiques des tumeurs cutanées. In: Ten Seldan R, Helwig R (Eds). Classification histologique internationale des tumeurs. Genève: WHO Inc 1975: 49-50.
  • Ozgediz D, Smith EB, Zheng J, Otero J, Tabatabai ZL, Corvera CU. Basal cell carcinoma does metastasize. Dermatol Online J 2008; 14: 5.
  • Rigel DS, Robins P, Friedman RJ. Predicting recurrence of basal-cell carcinomas treated by microscopically controlled excision: A recurrence index score. J Dermatol Surg Oncol 1981; 7: 807-10.
  • Gropper AB, Girouard SD, Hojman LP, Huang SJ, Qian X, Murphy GF, Vleugels RA. Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature. J Cutan Pathol 2012; 39: 526-34.
  • Rowe DE, Carroll RJ, Day CL Jr. Long-term recurrence rates in previously untreated (primary) basal cell carcinoma: implications for patient follow-up. J Dermatol Surg Oncol 1989; 15: 315-28.
  • Hauben DJ, Zirkin H, Mahler D, Sacks M. The biologic behavior of basal cell carcinoma: analysis of recurrence in excised basal cell carcinoma: Part II. Plast Reconstr Surg 1982; 69: 110-6.
  • Dixon AY, Lee SH, McGregor DH.Factors predictive of recurrence of basal cell carcinoma. Am J Dermatopathol 1989; 11: 222-32.
  • Dixon AY, Lee SH, McGregor DH. Histologic features predictive of basal cell carcinoma recurrence: Results of a multivariate analysis. J Cutan Pathol 1993; 20: 137-42.
  • Chakrabarty A, Geisse JK. Medical therapies for non-melanoma skin cancer. Clin Dermatol 2004; 22: 183-8.
  • Gibbs P, Gonzalez R, Lee LA, Walsh P. Medical management of cutaneous malignancies. Clin Dermatol 2001; 19: 298-304.
  • Seegenschmiedt MH, Oberste-Beulmann S, Lang E, Lang B, Guntrum F, Olschewski T. Radiotherapy for basal cell carcinoma. Local control and cosmetic outcome. Strahlenther Onkol 2001; 177: 240-6.
  • Kwan W, Wilson D, Moravan V. Radiotherapy for locally advanced basal cell and squamous cell carcinomas of the skin. Int J Radiat Oncol Biol Phys 2004; 60: 406-11.
  • Varga E, Korom I, Raskó Z, Kis E, Varga J, Oláh J, Kemény L. Neglected Basal cell carcinomas in the 21st century. J Skin Cancer 2011; 2011: 392151.
  • Heo YS, Yoon JH, Choi JE, Ahn HH, Kye YC, Seo SH A case of superficial giant Basal cell carcinoma with satellite lesions on scalp. Ann Dermatol 2011; 23: S111-5.
There are 23 citations in total.

Details

Primary Language English
Journal Section Case Reports
Authors

Havva Erdem

Nilüfer Kadıoğlu

Ali Uzunlar

Ümran Yıldırım

Murat Oktay

Cem Şahiner

Derya Özçelik

Hakan Turan

Publication Date April 7, 2012
Published in Issue Year 2012Volume: 34 Issue: 4

Cite

AMA Erdem H, Kadıoğlu N, Uzunlar A, Yıldırım Ü, Oktay M, Şahiner C, Özçelik D, Turan H. An aggressive Basal Cell Carcinoma with multiple focuses and distant lung metastasis: case report. CMJ. December 2012;34(4):510-515.