Abstract
Langerhans Cell Histiocytosis is termed as a group of diseases that leads to have same histopathology, but different clinical symptoms. The disease has 3 distinct forms and the localized form is termed as Eosinophilic granuloma . Eosinophilic granuloma is the localized form of which has the least clinical severity and the most favourable subtype in Langerhans Cell Histiocytosis group. The treatment options are available as surgery removal, chemotherapy, and radiotherapy alone or in combinations. In this paper, a young adult patient was represented who referred to our clinic with complaints of swelling and pain on right occipital region, and who diagnosed as Langerhans Cell Histiocytosis (Eosinophilic granuloma) after evaluation of radiologic tests and histopathologic survey.
References
- Leatherwood DL, Heitkamp DE, Emerson RE. Best cases from the AFIP: Pulmonary Langerhans cell histiocytosis. Radiographics 2007; 27: 265-8.
- Minkov M, Grois N, Braier J, Rosso D, Aricò M, Broadbent V, Gadner H, Ladisch S; Histiocyte Society. Immunosuppressive treatment for chemotherapyresistant multisystem Langerhans cell histiocytosis. Med Pediatr Oncol 2003; 40: 253Madrigal-Martínez-Pereda C, Guerrero-Rodríguez V, Guisado-Moya B, MenizGarcía C. Langerhans cell histiocytosis: Literature review and descriptive analysis of oral manifestations. Med Oral Patol Oral Cir Bucal 2009; 14: 222-8. Scolozzi P, Lombardi T, Monnier P, Jaques B. Multisystem Langerhans' cell histiocytosis (Hand-Schüller-Christian disease) in an adult: A case report and review of the literature. Eur Arch Otorhinolaryngol 2004; 261: 326-30.
- Meyer JS, De Camargo B. The role of radiology in the diagnosis and follow-up of Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998; 12: 307-26. Sezer ÖC, Alpar S, Bakırcı T, Demirağ F, Kurt B. Diabetes insipidus ile Birlikte Olan Pulmoner Histiositozis X Olgusu. Türkiye Klinikleri Arch Lung 2001; 2: 156Gadner H, Heitger A, Grois N, Gatterer-Menz I, Ladisch S. Treatment strategy for disseminated Langerhans cell histiocytosis. DAL HX-83 Study Group. Med Pediatr Oncol 1994; 23: 72-80.
- Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, Komp D, Michaelis J, Nicholson S, Pötschger U, Pritchard J, Ladisch S; Histiocyte Society. A randomized trial of treatment for multisystem Langerhans’ cell histiocytosis. J Pediatr 2001; 138: 728-34.
- Gadner H, Grois N, Pötschger U, Minkov M, Aricò M, Braier J, Broadbent V, Donadieu J, Henter JI, McCarter R, Ladisch S; Histiocyte Society. Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Blood 2007; 111: 2556-62.
- Minkov M, Grois N, Heitger A, Pötschger U, Westermeier T, Gadner H. Treatment of multisystem Langerhans cell histiocytosis. Results of the DAL-HX 83 and DAL-HX 90 studies. DAL-HX Study Group. Klin Padiatr 2000; 212: 139
- A multicentre retrospective survey of Langerhans' cell histiocytosis: 348 cases observed between 1983 and 1993. The French Langerhans' Cell Histiocytosis Study Group. Arch Dis Child 1996; 75: 17-24.
- Kahilogullari G, Tuna H, Kuzu I, Ünlü A. Orbital Eosinophilic Granuloma in a Child: A Case Report. Turkish Neurosurgery 2013; 23: 575-7.
- Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK. Langerhans’ cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer 1995; 76: 2471-84.
- Aydın MA, Baykul T, Nasir S, Altuntaş SH, Türkaslan SS, Fındık Y. Misdiagnosed widespread eosinophilic granuloma of the mandible. J Craniofac Surg 2012; 23: e361-4.
- Erdem H, Kadıoğlu N, Uzunlar AK, Yücel I, Oktay M, Beşir FH. Langerhans Cell Histiocytosis Mimicking Osteomyelitis in an Infant. APSP J Case Rep 2013; 4: Bozdemir K, Tarlak B, Cakar H, Doblan A, Kutluhan A, Dilek I, Adıyaman Süngü N. Langerhans cell histiocytosis in bilateral mastoid cavity. Case Rep Otolaryngol 2013; 2013: 957926.
- Donadieu J, Chalard F, Jeziorski E. Medical management of langerhans cell histiocytosis from diagnosis to treatment. Expert Opin Pharmacother 2012; 13: 1309Martinez-Lage JF, Poza M, Cartagena J, Vicente JP, Biec F, de las Heras M. Solitary eosinophilic granuloma of the pediatric skull and spine. The role of surgery. Childs Nerv Syst 1991; 7: 448-51.
- Rawlings CE 3rd, Wilkins RH. Solitary eosinophilic granuloma of the skull. Neurosurgery 1984; 15: 155-61.
- Oliveira M, Steinbok P, Wu J, Heran N, Cochrane D. Spontaneous resolution of calvarial eosinophilic granuloma in children. Pediatr Neurosurg 2003; 38: 2475
Abstract
Özet
Langerhans Hücreli Histiyositozis aynı histopatolojiye sahip fakat farklı klinik semptomlara neden olan hastalıklar grubu olarak adlandırılmaktadır. Üç ayrı formu olan hastalığın lokalize formu Eozinofilik granulom olarak isimlendirilmektedir. Eosinofilik granülom, Langerhans Hücreli Histiyositozis grubu içerisinde klinik seyri en az şiddetli ve lokalize form olup en iyi prognoza sahip alt tiptir. Tedavi şeçenekleri arasında, cerrahi eksizyon, kemoterapi, radyoterapi tek başına kullanılabileceği gibi kombine kullanımları da bulunmaktadır. Burada, sağ oksipital bölgede şişlik ve ağrı şikayeti ile kliniğimize başvuran, radyolojik tetkikleri ve histopatolojik incelemesi sonucunda Langerhans Hücreli Histiyositozis (Eosinifilik granülom) tanısı alan genç erişkin bir hasta sunuldu.
Anahtar sözcükler: Langerhans hücreli histiyositozis, eozinofilik granülom, soliter kemik lezyonu
Abstract
Langerhans Cell Histiocytosis is termed as a group of diseases that leads to have same histopathology, but different clinical symptoms. The disease has 3 distinct forms named as fulminant (Letterer-Siwe disease), chronic recurrent (Hand-Schüller-Christian disease) and localized (Eosinophilic granuloma). Eosinophilic granuloma is typically found in children and is characterized with one or more lytic bone lesions. Eosinophilic granuloma is the localized form of which has the least clinical severity and the most favourable subtype in Langerhans Cell Histiocytosis group. The treatment options are available as surgery removal, chemotherapy, and radiotherapy alone or in combinations. In this paper, a young adult patient was represented who referred to our clinic with complaints of swelling and pain on right occipital region, and who diagnosed as Langerhans Cell Histiocytosis (Eosinophilic granuloma) after evaluation of radiologic tests and histopathologic survey.
Keywords: Langerhans’ Cell Histiocytosis, Eosinophilic granuloma, solitary bone lesionReferences
- Leatherwood DL, Heitkamp DE, Emerson RE. Best cases from the AFIP: Pulmonary Langerhans cell histiocytosis. Radiographics 2007; 27: 265-8.
- Minkov M, Grois N, Braier J, Rosso D, Aricò M, Broadbent V, Gadner H, Ladisch S; Histiocyte Society. Immunosuppressive treatment for chemotherapyresistant multisystem Langerhans cell histiocytosis. Med Pediatr Oncol 2003; 40: 253Madrigal-Martínez-Pereda C, Guerrero-Rodríguez V, Guisado-Moya B, MenizGarcía C. Langerhans cell histiocytosis: Literature review and descriptive analysis of oral manifestations. Med Oral Patol Oral Cir Bucal 2009; 14: 222-8. Scolozzi P, Lombardi T, Monnier P, Jaques B. Multisystem Langerhans' cell histiocytosis (Hand-Schüller-Christian disease) in an adult: A case report and review of the literature. Eur Arch Otorhinolaryngol 2004; 261: 326-30.
- Meyer JS, De Camargo B. The role of radiology in the diagnosis and follow-up of Langerhans cell histiocytosis. Hematol Oncol Clin North Am 1998; 12: 307-26. Sezer ÖC, Alpar S, Bakırcı T, Demirağ F, Kurt B. Diabetes insipidus ile Birlikte Olan Pulmoner Histiositozis X Olgusu. Türkiye Klinikleri Arch Lung 2001; 2: 156Gadner H, Heitger A, Grois N, Gatterer-Menz I, Ladisch S. Treatment strategy for disseminated Langerhans cell histiocytosis. DAL HX-83 Study Group. Med Pediatr Oncol 1994; 23: 72-80.
- Gadner H, Grois N, Arico M, Broadbent V, Ceci A, Jakobson A, Komp D, Michaelis J, Nicholson S, Pötschger U, Pritchard J, Ladisch S; Histiocyte Society. A randomized trial of treatment for multisystem Langerhans’ cell histiocytosis. J Pediatr 2001; 138: 728-34.
- Gadner H, Grois N, Pötschger U, Minkov M, Aricò M, Braier J, Broadbent V, Donadieu J, Henter JI, McCarter R, Ladisch S; Histiocyte Society. Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Blood 2007; 111: 2556-62.
- Minkov M, Grois N, Heitger A, Pötschger U, Westermeier T, Gadner H. Treatment of multisystem Langerhans cell histiocytosis. Results of the DAL-HX 83 and DAL-HX 90 studies. DAL-HX Study Group. Klin Padiatr 2000; 212: 139
- A multicentre retrospective survey of Langerhans' cell histiocytosis: 348 cases observed between 1983 and 1993. The French Langerhans' Cell Histiocytosis Study Group. Arch Dis Child 1996; 75: 17-24.
- Kahilogullari G, Tuna H, Kuzu I, Ünlü A. Orbital Eosinophilic Granuloma in a Child: A Case Report. Turkish Neurosurgery 2013; 23: 575-7.
- Kilpatrick SE, Wenger DE, Gilchrist GS, Shives TC, Wollan PC, Unni KK. Langerhans’ cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases. Cancer 1995; 76: 2471-84.
- Aydın MA, Baykul T, Nasir S, Altuntaş SH, Türkaslan SS, Fındık Y. Misdiagnosed widespread eosinophilic granuloma of the mandible. J Craniofac Surg 2012; 23: e361-4.
- Erdem H, Kadıoğlu N, Uzunlar AK, Yücel I, Oktay M, Beşir FH. Langerhans Cell Histiocytosis Mimicking Osteomyelitis in an Infant. APSP J Case Rep 2013; 4: Bozdemir K, Tarlak B, Cakar H, Doblan A, Kutluhan A, Dilek I, Adıyaman Süngü N. Langerhans cell histiocytosis in bilateral mastoid cavity. Case Rep Otolaryngol 2013; 2013: 957926.
- Donadieu J, Chalard F, Jeziorski E. Medical management of langerhans cell histiocytosis from diagnosis to treatment. Expert Opin Pharmacother 2012; 13: 1309Martinez-Lage JF, Poza M, Cartagena J, Vicente JP, Biec F, de las Heras M. Solitary eosinophilic granuloma of the pediatric skull and spine. The role of surgery. Childs Nerv Syst 1991; 7: 448-51.
- Rawlings CE 3rd, Wilkins RH. Solitary eosinophilic granuloma of the skull. Neurosurgery 1984; 15: 155-61.
- Oliveira M, Steinbok P, Wu J, Heran N, Cochrane D. Spontaneous resolution of calvarial eosinophilic granuloma in children. Pediatr Neurosurg 2003; 38: 2475
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | March 28, 2014 |
| Published in Issue | Year 2014Volume: 36 Issue: 1 |