Investigation of the relationship between Abdominal Aortic Calcified Plaques deter-mined by multidetector computed tomogra-phy (MDCT) and Body Mass Index (BMI)
Abstract
SUMMARY
Objective: Potential correlation between abdominal aortic atherosclerosis measured by multidetector computed tomography (MDCT) and body mass index (BMI) is investigated in this presented study.
Method: The presented study includes 228 patients between July 2013 and January 2014 in our clinic. Calcium scores of abdominal aortic calcified plaques (AaCs) between celiac trunk and iliac bifurcation in axial sections were measured as Agatston units (AU.). Following the abdominal computed tomography (CT) scans, all patient’s heights and weights were obtained from medical reports. Their body mass indexes (BMI) were calculated by dividing these two variables. Patients were then grouped according to World Health Organization Expert Committee on Physical Status. BMIs under 25 kg/m2 were categorized as normal weighted group (Group 1), BMIs between 25 - 29.9 kg/m2 were grouped as overweighted (Group 2), and BMIs equal or over 30 kg/m2 were accepted as obese group (Group 3).
Results: Mean BMIs - AaCs in Group 1, 2, and 3 were found to be 22.3 ± 1.6 - 254 ± 597 AU, 27.4 ± 1.4 - 244.5 ± 496.7 AU, 33.4 ± 2.6 - 368.2 ± 604.5 AU, respectively.
Conclusions: According to correlation analysis, no significant correlation was observed between BMI and AaCs in these subgroups.
Keywords: Multidedector computed tomography, body mass index, arteriosclerosis, calcification
ÖZET
Amaç: Bu çalışmada, multidedektörlü BT (MDBT) ile ölçülmüş abdominal aort aterosklerozu ve vücut kitle indeksi arasında olası ilişki araştırıldı.
Yöntem: Çalışmamız kliniğimizde temmuz 2013 ve ocak 2014 tarihleri arasında kontrassız abdominal BT çekilen 228 kişiyi içermektedir. BT aksiyel kesitlerde çöliyak trunkus ve iliak bifurkasyon arasında abdominal aort kalsifik plaklarının kalsiyum skorları (AaCs) Agatston üniti (a.u) olarak ölçüldü Tüm hastalarımızın abdominal BT çekim sonrasında, boy (İnsan baskülü, NAN TARTI AŞ, Türkiye) ve kiloları (TANITA Body Composition Analyzer, TANITA Corporation, Japan) ölçüldü. Vücut kitle indeksleri hesaplandı. BMI’i 25 kilogram (kg)/metrekare (m2) nin altında olanlar (BMI<25 kg/m2) normal kilolu (Grup 1), 25 kg/m2 ile 29,9 kg/m2 arasında olanlar (25 kg/m2 ≤BMI<29,9 kg/m2) aşırı kilolu (Grup 2), 30 kg/m2 ve üstünde olanlar (30 kg/m2≤ BMI) obez (Grup 3) kabul edildi.
Bulgular: Çalışmaya katılan tüm bireylerin yaş dağılımı; minimum(min) 20 yıl (y), maksimum(max) 87 yıldır (ortalama ± standart sapma 44,1 ± 14,2 y). Bu kişilerin 150’si (%65,8) erkek, 78’i (%34,2) kadındır. Çalışmaya katılanlar arasında; Aortik kalsiyum skoru (AaCs) min 0 au, max 2201 au (ortalama ± standart sapma 286,3 ± 561,5), BMI min 18, max 41 (ortalama ± standart sapma 27,9 ± 4,7) olarak tespit edildi.
Sonuç: BMI grupları ile AaCs arasında korelasyon analizi yapıldı. Anlamlı ilişki tespit edilmedi (Grafik 1).
Anahtar sözcükler: Multidedektörlü bilgisayarlı tomografi, vücut kitle indeksi, arteriyoskleroz, kalsifikasyon
References
- Flegal KM, Carroll MD, Kuczmar- ski RJ. Overweight and obesity in the United States: prevalence and trends. Int J Obes Relat Metab Disord 1998; 22: 39-47.
- Flegal KM, Carroll MD, Ogden CL. Prevalence and trends in obe- sity among US adults. JAMA 2002; 2881723-7.
- Ogden CL, Carroll MD, Curtin LR. Prevalence of overweight and obesity in the United States. JA- MA 2006; 295: 1549-55.
- Wong ND, Hsu JC, Detrano RC. Coronary artery calcium evalua- tion by electron beam computed tomography and its relation to new cardiovascular events. Am J Car- diol 2000; 86: 495-8.
- Arad Y, Spadaro LA, Goodman K. Predictive value of electron beam computed tomography of the coro- nary arteries. 19-month follow-up of 1173 asymptomatic subjects. Circulation 1996; 93: 1951-3.
- Detrano R, Guerci AD, Carr JJ. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 2008; 358: 1336-45.
- Poirier P, Giles TD, Bray GA. Obesity and cardiovascular dis- ease: pathophysiology, evaluation and effect of weight loss: an up- date of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, physical activity, and metabolism. 113: 898-918. 2006;
- Rosengren A, Wedel H, Wilhelm- sen L. Body weight and weight gain during adult life in men in re- lation to coronary heart disease and mortality. A prospective popu- lation study. Eur Heart J 1999; 20: 269-77.
- Breeze E, Clarke R, Shipley MJ. Cause-specifi mortality in old age in relation to body mass index in middle age and in old age: follow- up of the Whitehall cohort of male civil servants. Int J Epidemiol 2006; 35: 169-78.
- Bamia C, Halkjaer J, Lagiou P. Weight change in later life and risk of death amongst the elderly: the European prospective investigation into cancer and nutrition-elderly network on ageing and health study. J Intern Med 2010; 268: 133-44.
- Jelic S, Bartels MN, Mateika JH. Arterial stiffness increases during obstructive sleep apneas. Sleep 2002; 25: 850-5.
- Hall JE. The kidney, hypertension, and obesity. Hypertension 2003; 41: 625-33.
- Walsh CR, Cupples LA, Levy D. Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study. Am Heart J 2002; 144: 733-9.
- World Health Organization. Physi- cal status: the use and interpreta- tion of anthropometry. Report of a WHO World Health Organization tech- nical report series 1995; 854: 1- 452.
- Wexler L, Brundage B, Crouse J. artery Coronary pathophysiology, imaging methods, and clinical im- plications: a statement for health professionals from the American Heart Association Writing Group. Circulation 1996; 94: 1175-92.
- Rumberger JA, Simons DB, Fitz- patrick LA. Coronary artery calci- um area by electron-beam comput- ed tomography and coronary ath- erosclerotic plaque area: a histo- pathologic correlative study. Cir- culation 1995; 92: 2157-62.
- Simon A, Giral P, Levenson J. Ex- tracoronary atherosclerotic plaque at multiple sites and total coronary calcification deposit in asympto- matic men: association with coro- nary risk profile. Circulation 1995; 92: 1414-21.
- Allison MA, Criqui MH, Wright CM: Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 331-6.
- Hoff JA, Chomka EV, Krainik AJ. Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol 2001; 87: 1335-9.
- Teale C, Romaniuk C, Mulley G. Calcification on chest radiographs: the association with age. Age Age- ing 1989; 18: 333-6.
- Gorich J, Zuna I, Merle M. Aortic calcification in CT: correlation with risk factors and cardiovascu- lar diseases. Radiologe 1989; 29: 614.
- Iribarren C, Sidney S, Sternfeld B. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA 2000; 283: 2810-5.
- Pacchioni A, Rossi A, Benfari G. A higher body mass index is asso- ciated with reduced prevalence of unstable atherosclerotic plaque: a possible explanation of the obesity paradox.Int J Cardiol 2013; 168: 2912-3.
Abdominal Aort Kalsifik plak oluşumu ile Vücut Kitle İndeksi arasındaki ilişkinin MDCT ile araştırılması
Abstract
Amaç: Bu çalışmada, multidedektörlü BT (MDBT) ile ölçülmüş abdominal aort aterosklerozu ve vücut kitle indeksi arasında olası ilişki araştırıldı. Yöntem: Çalışmamız kliniğimizde temmuz 2013 ve ocak 2014 tarihleri arasında kontrassız abdominal BT çekilen 228 kişiyi içermektedir. BT aksiyel kesitlerde çöliyak trunkus ve iliak bifurkasyon arasında abdominal aort kalsifik plaklarının kalsiyum skorları (AaCs) Agatston üniti (a.u) olarak ölçüldü Tüm hastalarımızın abdominal BT çekim sonrasında, boy (İnsan baskülü, NAN TARTI AŞ, Türkiye) ve kiloları (TANITA Body Composition Analyzer, TANITA Corporation, Japan) ölçüldü. Vücut kitle indeksleri hesaplandı. BMI’i 25 kilogram (kg)/metrekare (m2) nin altında olanlar (BMI<25 kg/m2) normal kilolu (Grup 1), 25 kg/m2 ile 29,9 kg/m2 arasında olanlar (25 kg/m2 ≤BMI<29,9 kg/m2) aşırı kilolu (Grup 2), 30 kg/m2 ve üstünde olanlar (30 kg/m2≤ BMI) obez (Grup 3) kabul edildi. Bulgular: Çalışmaya katılan tüm bireylerin yaş dağılımı; minimum(min) 20 yıl (y), maksimum(max) 87 yıldır (ortalama ± standart sapma 44,1 ± 14,2 y). Bu kişilerin 150’si (%65,8) erkek, 78’i (%34,2) kadındır. Çalışmaya katılanlar arasında; Aortik kalsiyum skoru (AaCs) min 0 au, max 2201 au (ortalama ± standart sapma 286,3 ± 561,5), BMI min 18, max 41 (ortalama ± standart sapma 27,9 ± 4,7) olarak tespit edildi. Sonuç: BMI grupları ile AaCs arasında korelasyon analizi yapıldı. Anlamlı ilişki tespit edilmedi
References
- Flegal KM, Carroll MD, Kuczmar- ski RJ. Overweight and obesity in the United States: prevalence and trends. Int J Obes Relat Metab Disord 1998; 22: 39-47.
- Flegal KM, Carroll MD, Ogden CL. Prevalence and trends in obe- sity among US adults. JAMA 2002; 2881723-7.
- Ogden CL, Carroll MD, Curtin LR. Prevalence of overweight and obesity in the United States. JA- MA 2006; 295: 1549-55.
- Wong ND, Hsu JC, Detrano RC. Coronary artery calcium evalua- tion by electron beam computed tomography and its relation to new cardiovascular events. Am J Car- diol 2000; 86: 495-8.
- Arad Y, Spadaro LA, Goodman K. Predictive value of electron beam computed tomography of the coro- nary arteries. 19-month follow-up of 1173 asymptomatic subjects. Circulation 1996; 93: 1951-3.
- Detrano R, Guerci AD, Carr JJ. Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 2008; 358: 1336-45.
- Poirier P, Giles TD, Bray GA. Obesity and cardiovascular dis- ease: pathophysiology, evaluation and effect of weight loss: an up- date of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, physical activity, and metabolism. 113: 898-918. 2006;
- Rosengren A, Wedel H, Wilhelm- sen L. Body weight and weight gain during adult life in men in re- lation to coronary heart disease and mortality. A prospective popu- lation study. Eur Heart J 1999; 20: 269-77.
- Breeze E, Clarke R, Shipley MJ. Cause-specifi mortality in old age in relation to body mass index in middle age and in old age: follow- up of the Whitehall cohort of male civil servants. Int J Epidemiol 2006; 35: 169-78.
- Bamia C, Halkjaer J, Lagiou P. Weight change in later life and risk of death amongst the elderly: the European prospective investigation into cancer and nutrition-elderly network on ageing and health study. J Intern Med 2010; 268: 133-44.
- Jelic S, Bartels MN, Mateika JH. Arterial stiffness increases during obstructive sleep apneas. Sleep 2002; 25: 850-5.
- Hall JE. The kidney, hypertension, and obesity. Hypertension 2003; 41: 625-33.
- Walsh CR, Cupples LA, Levy D. Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study. Am Heart J 2002; 144: 733-9.
- World Health Organization. Physi- cal status: the use and interpreta- tion of anthropometry. Report of a WHO World Health Organization tech- nical report series 1995; 854: 1- 452.
- Wexler L, Brundage B, Crouse J. artery Coronary pathophysiology, imaging methods, and clinical im- plications: a statement for health professionals from the American Heart Association Writing Group. Circulation 1996; 94: 1175-92.
- Rumberger JA, Simons DB, Fitz- patrick LA. Coronary artery calci- um area by electron-beam comput- ed tomography and coronary ath- erosclerotic plaque area: a histo- pathologic correlative study. Cir- culation 1995; 92: 2157-62.
- Simon A, Giral P, Levenson J. Ex- tracoronary atherosclerotic plaque at multiple sites and total coronary calcification deposit in asympto- matic men: association with coro- nary risk profile. Circulation 1995; 92: 1414-21.
- Allison MA, Criqui MH, Wright CM: Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol 2004; 24: 331-6.
- Hoff JA, Chomka EV, Krainik AJ. Age and gender distributions of coronary artery calcium detected by electron beam tomography in 35,246 adults. Am J Cardiol 2001; 87: 1335-9.
- Teale C, Romaniuk C, Mulley G. Calcification on chest radiographs: the association with age. Age Age- ing 1989; 18: 333-6.
- Gorich J, Zuna I, Merle M. Aortic calcification in CT: correlation with risk factors and cardiovascu- lar diseases. Radiologe 1989; 29: 614.
- Iribarren C, Sidney S, Sternfeld B. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA 2000; 283: 2810-5.
- Pacchioni A, Rossi A, Benfari G. A higher body mass index is asso- ciated with reduced prevalence of unstable atherosclerotic plaque: a possible explanation of the obesity paradox.Int J Cardiol 2013; 168: 2912-3.
Details
| Primary Language | English |
|---|---|
| Journal Section | Medical Science Research Articles |
| Authors | |
| Publication Date | January 10, 2015 |
| Published in Issue | Year 2015Volume: 37 Issue: 3 |