Research Article
Year 2021,
Volume: 43 Issue: 2, 182 - 188, 01.07.2021
Abstract
References
- 1. Storry J, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology. 2009;25(2):48.
- 2. Siransy LK, Nanga ZY, Zaba FS, Tufa NY, Dasse SR. ABO/Rh blood groups and risk of HIV infection and Hepatitis B among blood donors of Abidjan, Côte D’ivoire. European Journal of Microbiology and Immunology. 2015;5(3):205-209.
- 3. Farhud DD, Yeganeh MZ. A brief history of human blood groups. Iranian Journal of Public Health. 2013;42(1):1-6.
- 4. Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfusion. 2016;14(5):434.
- 5. Mao Y, Yang W, Qi Q, et al. Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review. BMC cancer. 2019;19(1):1-9.
- 6. Wolpin BM, Chan AT, Hartge P, et al. ABO Blood Group and the Risk of Pancreatic Cancer. JNCI: Journal of the National Cancer Institute. 2009;101(6):424-431.
- 7. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. European Journal of Cancer. 2010;46(18):3345-3350.
- 8. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. International Journal of Cancer. 2012;130(9):2129-2137.
- 9. Anstee D. The relationship between blood groups and disease. Blood. 2010;115(23):4635-4643.
- 10. Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood transfusion. 2013;11(4):491.
- 11. Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: the most recent evidence of association. Journal of thrombosis and thrombolysis. 2014;38(2):160-166.
- 12. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC medicine. 2015;13(1):1-3.
- 13. Schwarz HP, Dorner F. Karl Landsteiner and his major contributions to haematology. British journal of haematology. 2003;121(4):556-565.
- 14. Tan SY, Graham C. Karl Landsteiner (1868-1943): originator of ABO blood classification. Singapore Med J. 2013;54(5):243-244.
- 15. Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (vol 68, pg 394, 2018). CA-A CANCER JOURNAL FOR CLINICIANS. 2020;70(4):313-313.
- 16. Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. American journal of epidemiology. 2010;172(11):1280-1285.
- 17. Huang JY, Wang R, Gao Y-T, Yuan J-M. ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one. 2017;12(9):e0184295.
- 18. Akin S, Altundag K. Clinical associations with abo blood group and rhesus blood group status in patients with breast cancer: a nationwide retrospective study of 3,944 breast cancer patients in Turkey. Medical science monitor: international medical journal of experimental and clinical research. 2018;24:4698.
- 19. Luzón-Toro B, Fernández RM, Villalba-Benito L, Torroglosa A, Antiñolo G, Borrego S. Influencers on thyroid cancer onset: molecular genetic basis. Genes. 2019;10(11):913.
- 20. Tam AA, Özdemir D, Fakı S, Bilginer MC, Ersoy R, Çakır B. ABO Blood Groups, Rh Factor, and Thyroid Cancer Risk: To ‘B’or Not to ‘B’. Endocrine research. 2020;45(2):137-146.
- 21. Tanaka Y, Kumagi T, Terao T, et al. ABO Blood Type and the Long-term Outcomes of Pancreatic Cancer. Internal Medicine. 2020;59(6):761-768.
- 22. Aktaş A, Gamze Ü. Evaluation of the distribution of ABO and Rh blood groups in Sivas province. Cumhuriyet Medical Journal.43(1):55-61.
Distribution of AB0 and Rh blood groups in cancer patients; is A Rh (+) blood group a risk factor in colorectal cancer development?
Abstract
Objective: Genetic factors have been the subject of many studies in cancer etiology. One of the most striking of these is the relationship between blood groups and cancer. Therefore, in our study, we examined the relationship between blood groups of stomach, colorectal, breast, thyroid and pancreatic cancers, which are common in general surgery practice, with single-center data.
Method: We retrospectively analyzed cancer cases who applied to our University Hospital between 2005-2021. This analysis was done using a hospital database. 7899 cancer patients were included in the study. Cancer types, blood types, ages and gender of the patients were recorded. Results were analyzed statistically.
Results: 55.2% of the patients included in the study were male and 42.8% were female. Of the patients, 553 (7%) were stomach, 767 (9.7%) colorectal, 779 (9.9%) breast, 625 (55.15%) thyroid, 209 (2.6% ) pancreatic cancer. 87.4% of the patients were Rh (+), 12.6% of them were Rh (-). 38% of patients A Rh (+), 5.2% A Rh (-), 13.8% B Rh (+), 2.2% B Rh (-), 7.7% AB Rh (+), 1.3% AB Rh (-), 28% 0 Rh (+), 3.8% 0 Rh (-). With the blood group distribution of all cancers; When the blood group distribution of gastric, colorectal, breast, thyroid and pancreatic cancers were compared, no statistically significant difference was found. However, it was found that the A Rh (+) blood group was higher in colorectal cancers compared to other cancers.
Conclusions: In our study, no relationship was found between all cancers and blood type. In addition, no relationship was found between blood type and stomach, colorectal, breast, thyroid and pancreatic cancers, which are common in general surgery practice. Although it is generally accepted that especially A blood group is a risk factor for gastric cancer, there was no significant difference in our patient series. When AB0 and Rh blood groups were evaluated together, the A Rh (+) blood group was seen more in colorectal cancers.
Keywords
References
- 1. Storry J, Olsson ML. The ABO blood group system revisited: a review and update. Immunohematology. 2009;25(2):48.
- 2. Siransy LK, Nanga ZY, Zaba FS, Tufa NY, Dasse SR. ABO/Rh blood groups and risk of HIV infection and Hepatitis B among blood donors of Abidjan, Côte D’ivoire. European Journal of Microbiology and Immunology. 2015;5(3):205-209.
- 3. Farhud DD, Yeganeh MZ. A brief history of human blood groups. Iranian Journal of Public Health. 2013;42(1):1-6.
- 4. Franchini M, Liumbruno GM, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfusion. 2016;14(5):434.
- 5. Mao Y, Yang W, Qi Q, et al. Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review. BMC cancer. 2019;19(1):1-9.
- 6. Wolpin BM, Chan AT, Hartge P, et al. ABO Blood Group and the Risk of Pancreatic Cancer. JNCI: Journal of the National Cancer Institute. 2009;101(6):424-431.
- 7. Iodice S, Maisonneuve P, Botteri E, Sandri MT, Lowenfels AB. ABO blood group and cancer. European Journal of Cancer. 2010;46(18):3345-3350.
- 8. Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. International Journal of Cancer. 2012;130(9):2129-2137.
- 9. Anstee D. The relationship between blood groups and disease. Blood. 2010;115(23):4635-4643.
- 10. Liumbruno GM, Franchini M. Beyond immunohaematology: the role of the ABO blood group in human diseases. Blood transfusion. 2013;11(4):491.
- 11. Liumbruno GM, Franchini M. Hemostasis, cancer, and ABO blood group: the most recent evidence of association. Journal of thrombosis and thrombolysis. 2014;38(2):160-166.
- 12. Franchini M, Lippi G. The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer. BMC medicine. 2015;13(1):1-3.
- 13. Schwarz HP, Dorner F. Karl Landsteiner and his major contributions to haematology. British journal of haematology. 2003;121(4):556-565.
- 14. Tan SY, Graham C. Karl Landsteiner (1868-1943): originator of ABO blood classification. Singapore Med J. 2013;54(5):243-244.
- 15. Bray F, Ferlay J, Soerjomataram I, Siegel R, Torre L, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries (vol 68, pg 394, 2018). CA-A CANCER JOURNAL FOR CLINICIANS. 2020;70(4):313-313.
- 16. Edgren G, Hjalgrim H, Rostgaard K, et al. Risk of gastric cancer and peptic ulcers in relation to ABO blood type: a cohort study. American journal of epidemiology. 2010;172(11):1280-1285.
- 17. Huang JY, Wang R, Gao Y-T, Yuan J-M. ABO blood type and the risk of cancer–Findings from the Shanghai Cohort Study. PloS one. 2017;12(9):e0184295.
- 18. Akin S, Altundag K. Clinical associations with abo blood group and rhesus blood group status in patients with breast cancer: a nationwide retrospective study of 3,944 breast cancer patients in Turkey. Medical science monitor: international medical journal of experimental and clinical research. 2018;24:4698.
- 19. Luzón-Toro B, Fernández RM, Villalba-Benito L, Torroglosa A, Antiñolo G, Borrego S. Influencers on thyroid cancer onset: molecular genetic basis. Genes. 2019;10(11):913.
- 20. Tam AA, Özdemir D, Fakı S, Bilginer MC, Ersoy R, Çakır B. ABO Blood Groups, Rh Factor, and Thyroid Cancer Risk: To ‘B’or Not to ‘B’. Endocrine research. 2020;45(2):137-146.
- 21. Tanaka Y, Kumagi T, Terao T, et al. ABO Blood Type and the Long-term Outcomes of Pancreatic Cancer. Internal Medicine. 2020;59(6):761-768.
- 22. Aktaş A, Gamze Ü. Evaluation of the distribution of ABO and Rh blood groups in Sivas province. Cumhuriyet Medical Journal.43(1):55-61.
There are 22 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Surgical Science Research Articles |
| Authors | |
| Publication Date | July 1, 2021 |
| Acceptance Date | June 29, 2021 |
| Published in Issue | Year 2021Volume: 43 Issue: 2 |