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Year 2021, Volume: 43 Issue: 3, 263 - 270, 30.09.2021

Ismail Tarım , Can Akgün , Murat Derebey , Mesut Ozturk , Gökhan Selçuk Özbalcı , Cafer Polat

https://doi.org/10.7197/cmj.927183

Abstract

Supporting Institution

Hiçbir maddi destek alınmamıştır.

References

  • 1. Stern S, Mizrachi A, Strenov Y, Knaanie A, Benbassat C, Shpitzer T, Bachar G (2017) Parathyroid adenoma: a comprehensive biochemical and histological correlative study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 42 (2):381-386. doi:10.1111/coa.12761
  • 2. Uludağ M, Aygün N, İşgör A. Main Surgical Principles and Methods in Surgical Treatment of Primary Hyperparathyroidism. Sisli Etfal Hastan Tip Bul. 2019 Dec 3;53(4):337-352. doi: 10.14744/SEMB.2019.67944. PMID: 32377107; PMCID: PMC7192302.
  • 3. Kamani F, Najafi A, Mohammadi SS, Tavassoli S, Shojaei SP (2013) Correlation of biochemical markers of primary hyperparathyroidism with single adenoma weight and volume. The Indian journal of surgery 75 (2):102-105. doi:10.1007/s12262-012-0428-5
  • 4. Bindlish V, Freeman JL, Witterick IJ, Asa SL (2002) Correlation of biochemical parameters with single parathyroid adenoma weight and volume. Head & neck 24 (11):1000-1003. doi:10.1002/hed.10165
  • 5. Williams JG, Wheeler MH, Aston JP, Brown RC, Woodhead JS (1992) The relationship between adenoma weight and intact (1-84) parathyroid hormone level in primary hyperparathyroidism. American journal of surgery 163 (3):301-304. doi:10.1016/0002-9610(92)90007-e
  • 6. Ramas A, Jakubovic-Cičkisic A, Umihanic S, Sulejmanovic M, Brkic F (2019) Correlation Between the Parathyroid Glands Size and Parathormones Value in Patients with Hyperparathyroidism. Medical archives (Sarajevo, Bosnia and Herzegovina) 73 (4):249-252. doi:10.5455/medarh.2019.73.249-252
  • 7. Moretz WH, 3rd, Watts TL, Virgin FW, Jr., Chin E, Gourin CG, Terris DJ (2007) Correlation of intraoperative parathyroid hormone levels with parathyroid gland size. The Laryngoscope 117 (11):1957-1960. doi:10.1097/MLG.0b013e31813c14fc
  • 8. Aygün N, Uludağ M. Surgical Treatment of Primary Hyperparathyroidism: Which Therapy to Whom? Sisli Etfal Hastan Tip Bul. 2019 Aug 27;53(3):201-214. doi: 10.14744/SEMB.2019.56873. PMID: 32377085; PMCID: PMC7192265.
  • 9. Bilezikian JP, Brandi ML, Eastell R, Silverberg SJ, Udelsman R, Marcocci C, Potts JT, Jr (2014) Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Fourth International Workshop. The Journal of Clinical Endocrinology & Metabolism 99 (10):3561-3569. doi:10.1210/jc.2014-1413
  • 10. Irvin GL, 3rd, Solorzano CC, Carneiro DM (2004) Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome. World journal of surgery 28 (12):1287-1292. doi:10.1007/s00268-004-7708-6
  • 11. Richards ML, Thompson GB, Farley DR, Grant CS (2011) An optimal algorithm for intraoperative parathyroid hormone monitoring. Archives of surgery (Chicago, Ill : 1960) 146 (3):280-285. doi:10.1001/archsurg.2011.5
  • 12. Chiu B, Sturgeon C, Angelos P (2006) Which intraoperative parathyroid hormone assay criterion best predicts operative success? A study of 352 consecutive patients. Archives of surgery (Chicago, Ill : 1960) 141 (5):483-487; discussion 487-488. doi:10.1001/archsurg.141.5.483
  • 13. Patel KN, Caso R (2016) Intraoperative Parathyroid Hormone Monitoring: Optimal Utilization. Surgical oncology clinics of North America 25 (1):91-101. doi:10.1016/j.soc.2015.08.005
  • 14. Iacobone M, Scerrino G, Palazzo FF (2019) Parathyroid surgery: an evidence-based volume-outcomes analysis : European Society of Endocrine Surgeons (ESES) positional statement. Langenbeck's archives of surgery 404 (8):919-927. doi:10.1007/s00423-019-01823-9
  • 15. Riss P, Kaczirek K, Heinz G, Bieglmayer C, Niederle B (2007) A "defined baseline" in PTH monitoring increases surgical success in patients with multiple gland disease. Surgery 142 (3):398-404. doi:10.1016/j.surg.2007.05.004
  • 16. Mak N, Li J, Vasilyeva E, Hiebert J, Guo M, Lustig D, Holmes D, Wiseman SM (2020) Intraoperative parathyroid hormone measurement during parathyroidectomy for treatment of primary hyperparathyroidism: When should you end the operation? American journal of surgery 219 (5):785-789. doi:10.1016/j.amjsurg.2020.02.049
  • 17. Randhawa PS, Mace AD, Nouraei SA, Stearns MP (2007) Primary hyperparathyroidism: do perioperative biochemical variables correlate with parathyroid adenoma weight or volume? Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 32 (3):179-184. doi:10.1111/j.1365-2273.2007.01447.x
  • 18. Fang L, Tang B, Hou D, Meng M, Xiong M, Yang J (2015) Relationship between parathyroid mass and parathyroid hormone level in hemodialysis patients with secondary hyperparathyroidism. BMC nephrology 16:82. doi:10.1186/s12882-015-0077-6
  • 19. Ahmadi F, Aghajanzadeh P, Yazdi HR, Maziar S, Gatmiri SM (2016) The relationship between total mass and blood supply of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 27 (2):263-269. doi:10.4103/1319-2442.178257

Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery?

Year 2021, Volume: 43 Issue: 3, 263 - 270, 30.09.2021

Ismail Tarım , Can Akgün , Murat Derebey , Mesut Ozturk , Gökhan Selçuk Özbalcı , Cafer Polat

https://doi.org/10.7197/cmj.927183

Abstract

Objective: To study the relationship of intraoperative parathormone (PTH) decrease levels with solitary parathyroid adenoma (SPA) weight, diameter, and volume of the adenoma in patients with primary hyperparathyroidism (PHPT).
Method: Prospectively evaluation of consecutive patients undergoing parathyroidectomy (PTx) with the diagnosis of PHPT related to SPA. Perioperative biochemical parameters of patients; volume, weight and diameters of adenoma were recorded. Intraoperative PTH drop percentages were calculated. Adenoma diameter and volume were measured and calculated using preoperativ ultrasound. Adenoma was weighed intraoperatively by the surgeon.
Results: Forty-five consecutive patients underwent PTx for a SPA between October 2018 and October 2019. There were 9 men and 36 women, with a mean age of 51 ± 14.94 years. A positive correlation was identified between the volume with the weight and maximum diameter of resected parathyroid glands (r = 0.613, p< 0.001; r = 0.871, p< 0.001, respectively). There was a positive correlation between volume and preoperative PTH levels, albeit a weak one (r = 0.334, p = 0.025). No significant relationship was found between adenoma volume and ioPTH drop rate (r = 0.088, p = 0.565).
Conclusions: We have not been able to establish criteria based on correlation between PA volume and weight and the ioPTH drop rate that would allow us to make decisions on ending the parathyroidectomy and reducing persistent PHPT cases.

Keywords

Solitary parathyroid adenoma intraoperative parathyroid hormone parathyroid gland volume parathyroid gland weight

References

  • 1. Stern S, Mizrachi A, Strenov Y, Knaanie A, Benbassat C, Shpitzer T, Bachar G (2017) Parathyroid adenoma: a comprehensive biochemical and histological correlative study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 42 (2):381-386. doi:10.1111/coa.12761
  • 2. Uludağ M, Aygün N, İşgör A. Main Surgical Principles and Methods in Surgical Treatment of Primary Hyperparathyroidism. Sisli Etfal Hastan Tip Bul. 2019 Dec 3;53(4):337-352. doi: 10.14744/SEMB.2019.67944. PMID: 32377107; PMCID: PMC7192302.
  • 3. Kamani F, Najafi A, Mohammadi SS, Tavassoli S, Shojaei SP (2013) Correlation of biochemical markers of primary hyperparathyroidism with single adenoma weight and volume. The Indian journal of surgery 75 (2):102-105. doi:10.1007/s12262-012-0428-5
  • 4. Bindlish V, Freeman JL, Witterick IJ, Asa SL (2002) Correlation of biochemical parameters with single parathyroid adenoma weight and volume. Head & neck 24 (11):1000-1003. doi:10.1002/hed.10165
  • 5. Williams JG, Wheeler MH, Aston JP, Brown RC, Woodhead JS (1992) The relationship between adenoma weight and intact (1-84) parathyroid hormone level in primary hyperparathyroidism. American journal of surgery 163 (3):301-304. doi:10.1016/0002-9610(92)90007-e
  • 6. Ramas A, Jakubovic-Cičkisic A, Umihanic S, Sulejmanovic M, Brkic F (2019) Correlation Between the Parathyroid Glands Size and Parathormones Value in Patients with Hyperparathyroidism. Medical archives (Sarajevo, Bosnia and Herzegovina) 73 (4):249-252. doi:10.5455/medarh.2019.73.249-252
  • 7. Moretz WH, 3rd, Watts TL, Virgin FW, Jr., Chin E, Gourin CG, Terris DJ (2007) Correlation of intraoperative parathyroid hormone levels with parathyroid gland size. The Laryngoscope 117 (11):1957-1960. doi:10.1097/MLG.0b013e31813c14fc
  • 8. Aygün N, Uludağ M. Surgical Treatment of Primary Hyperparathyroidism: Which Therapy to Whom? Sisli Etfal Hastan Tip Bul. 2019 Aug 27;53(3):201-214. doi: 10.14744/SEMB.2019.56873. PMID: 32377085; PMCID: PMC7192265.
  • 9. Bilezikian JP, Brandi ML, Eastell R, Silverberg SJ, Udelsman R, Marcocci C, Potts JT, Jr (2014) Guidelines for the Management of Asymptomatic Primary Hyperparathyroidism: Summary Statement from the Fourth International Workshop. The Journal of Clinical Endocrinology & Metabolism 99 (10):3561-3569. doi:10.1210/jc.2014-1413
  • 10. Irvin GL, 3rd, Solorzano CC, Carneiro DM (2004) Quick intraoperative parathyroid hormone assay: surgical adjunct to allow limited parathyroidectomy, improve success rate, and predict outcome. World journal of surgery 28 (12):1287-1292. doi:10.1007/s00268-004-7708-6
  • 11. Richards ML, Thompson GB, Farley DR, Grant CS (2011) An optimal algorithm for intraoperative parathyroid hormone monitoring. Archives of surgery (Chicago, Ill : 1960) 146 (3):280-285. doi:10.1001/archsurg.2011.5
  • 12. Chiu B, Sturgeon C, Angelos P (2006) Which intraoperative parathyroid hormone assay criterion best predicts operative success? A study of 352 consecutive patients. Archives of surgery (Chicago, Ill : 1960) 141 (5):483-487; discussion 487-488. doi:10.1001/archsurg.141.5.483
  • 13. Patel KN, Caso R (2016) Intraoperative Parathyroid Hormone Monitoring: Optimal Utilization. Surgical oncology clinics of North America 25 (1):91-101. doi:10.1016/j.soc.2015.08.005
  • 14. Iacobone M, Scerrino G, Palazzo FF (2019) Parathyroid surgery: an evidence-based volume-outcomes analysis : European Society of Endocrine Surgeons (ESES) positional statement. Langenbeck's archives of surgery 404 (8):919-927. doi:10.1007/s00423-019-01823-9
  • 15. Riss P, Kaczirek K, Heinz G, Bieglmayer C, Niederle B (2007) A "defined baseline" in PTH monitoring increases surgical success in patients with multiple gland disease. Surgery 142 (3):398-404. doi:10.1016/j.surg.2007.05.004
  • 16. Mak N, Li J, Vasilyeva E, Hiebert J, Guo M, Lustig D, Holmes D, Wiseman SM (2020) Intraoperative parathyroid hormone measurement during parathyroidectomy for treatment of primary hyperparathyroidism: When should you end the operation? American journal of surgery 219 (5):785-789. doi:10.1016/j.amjsurg.2020.02.049
  • 17. Randhawa PS, Mace AD, Nouraei SA, Stearns MP (2007) Primary hyperparathyroidism: do perioperative biochemical variables correlate with parathyroid adenoma weight or volume? Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery 32 (3):179-184. doi:10.1111/j.1365-2273.2007.01447.x
  • 18. Fang L, Tang B, Hou D, Meng M, Xiong M, Yang J (2015) Relationship between parathyroid mass and parathyroid hormone level in hemodialysis patients with secondary hyperparathyroidism. BMC nephrology 16:82. doi:10.1186/s12882-015-0077-6
  • 19. Ahmadi F, Aghajanzadeh P, Yazdi HR, Maziar S, Gatmiri SM (2016) The relationship between total mass and blood supply of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 27 (2):263-269. doi:10.4103/1319-2442.178257
There are 19 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Surgical Science Research Articles
Authors

Ismail Tarım 0000-0002-6203-2644

Can Akgün 0000-0002-8367-0768

Murat Derebey 0000-0002-0654-846X

Mesut Ozturk 0000-0003-4059-2656

Gökhan Selçuk Özbalcı 0000-0003-0768-8306

Cafer Polat 0000-0001-8810-8128

Publication Date September 30, 2021
Acceptance Date September 24, 2021
Published in Issue Year 2021Volume: 43 Issue: 3

Cite

AMA Tarım I, Akgün C, Derebey M, Ozturk M, Özbalcı GS, Polat C. Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery?. CMJ. September 2021;43(3):263-270. doi:10.7197/cmj.927183