Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery?

Ismail Tarım; Can Akgün; Murat Derebey; Mesut Ozturk; Gökhan Selçuk Özbalcı; Cafer Polat

doi:10.7197/cmj.927183

EN

Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery?

Abstract

Objective: To study the relationship of intraoperative parathormone (PTH) decrease levels with solitary parathyroid adenoma (SPA) weight, diameter, and volume of the adenoma in patients with primary hyperparathyroidism (PHPT).

Method: Prospectively evaluation of consecutive patients undergoing parathyroidectomy (PTx) with the diagnosis of PHPT related to SPA. Perioperative biochemical parameters of patients; volume, weight and diameters of adenoma were recorded. Intraoperative PTH drop percentages were calculated. Adenoma diameter and volume were measured and calculated using preoperativ ultrasound. Adenoma was weighed intraoperatively by the surgeon.

Results: Forty-five consecutive patients underwent PTx for a SPA between October 2018 and October 2019. There were 9 men and 36 women, with a mean age of 51 ± 14.94 years. A positive correlation was identified between the volume with the weight and maximum diameter of resected parathyroid glands (r = 0.613, p< 0.001; r = 0.871, p< 0.001, respectively). There was a positive correlation between volume and preoperative PTH levels, albeit a weak one (r = 0.334, p = 0.025). No significant relationship was found between adenoma volume and ioPTH drop rate (r = 0.088, p = 0.565).

Conclusions: We have not been able to establish criteria based on correlation between PA volume and weight and the ioPTH drop rate that would allow us to make decisions on ending the parathyroidectomy and reducing persistent PHPT cases.

Keywords

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Ismail Tarım ^*
0000-0002-6203-2644
Türkiye

Can Akgün
0000-0002-8367-0768
Türkiye

Murat Derebey
0000-0002-0654-846X
Türkiye

Mesut Ozturk
0000-0003-4059-2656
Türkiye

Gökhan Selçuk Özbalcı
0000-0003-0768-8306
Türkiye

Cafer Polat
0000-0001-8810-8128
Türkiye

Publication Date

September 30, 2021

Submission Date

April 24, 2021

Acceptance Date

September 24, 2021

Published in Issue

Year 2021 Volume: 43 Number: 3

DOI

https://doi.org/10.7197/cmj.927183

IZ

https://izlik.org/JA29XP52DK

Cite

RIS / Bibtex

APA

Tarım, I., Akgün, C., Derebey, M., Ozturk, M., Özbalcı, G. S., & Polat, C. (2021). Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery? Cumhuriyet Medical Journal, 43(3), 263-270. https://doi.org/10.7197/cmj.927183

AMA

1.Tarım I, Akgün C, Derebey M, Ozturk M, Özbalcı GS, Polat C. Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery? CMJ. 2021;43(3):263-270. doi:10.7197/cmj.927183

Chicago

Tarım, Ismail, Can Akgün, Murat Derebey, Mesut Ozturk, Gökhan Selçuk Özbalcı, and Cafer Polat. 2021. “Correlation of Intraoperative Parathyroid Hormone Levels of Primary Hyperparathyroidism With Single Adenoma Volume and Weight: Can Optimal Criteria Be Created to End the Surgery?”. Cumhuriyet Medical Journal 43 (3): 263-70. https://doi.org/10.7197/cmj.927183.

EndNote

Tarım I, Akgün C, Derebey M, Ozturk M, Özbalcı GS, Polat C (September 1, 2021) Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery? Cumhuriyet Medical Journal 43 3 263–270.

IEEE

[1]I. Tarım, C. Akgün, M. Derebey, M. Ozturk, G. S. Özbalcı, and C. Polat, “Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery?”, CMJ, vol. 43, no. 3, pp. 263–270, Sept. 2021, doi: 10.7197/cmj.927183.

ISNAD

Tarım, Ismail - Akgün, Can - Derebey, Murat - Ozturk, Mesut - Özbalcı, Gökhan Selçuk - Polat, Cafer. “Correlation of Intraoperative Parathyroid Hormone Levels of Primary Hyperparathyroidism With Single Adenoma Volume and Weight: Can Optimal Criteria Be Created to End the Surgery?”. Cumhuriyet Medical Journal 43/3 (September 1, 2021): 263-270. https://doi.org/10.7197/cmj.927183.

JAMA

1.Tarım I, Akgün C, Derebey M, Ozturk M, Özbalcı GS, Polat C. Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery? CMJ. 2021;43:263–270.

MLA

Tarım, Ismail, et al. “Correlation of Intraoperative Parathyroid Hormone Levels of Primary Hyperparathyroidism With Single Adenoma Volume and Weight: Can Optimal Criteria Be Created to End the Surgery?”. Cumhuriyet Medical Journal, vol. 43, no. 3, Sept. 2021, pp. 263-70, doi:10.7197/cmj.927183.

Vancouver

1.Ismail Tarım, Can Akgün, Murat Derebey, Mesut Ozturk, Gökhan Selçuk Özbalcı, Cafer Polat. Correlation of intraoperative parathyroid hormone levels of primary hyperparathyroidism with single adenoma volume and weight: Can optimal criteria be created to end the surgery? CMJ. 2021 Sep. 1;43(3):263-70. doi:10.7197/cmj.927183