Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Diseases

Serpil Çiftel; Naciye Özlem Saygılı Yönem; Hilmi Ataseven; Sedat Çiftel; Ahmet Altun

doi:10.7197/cmj.1212431

Research Article

Comparison and Evaluation of CTGF and P2/MS as Noninvasive Markers in Fibrosis Evaluation in Chronic Liver Diseases

Year 2022, Volume: 44 Issue: 4, 443 - 448, 31.12.2022

Serpil Çiftel Naciye Özlem Saygılı Yönem Hilmi Ataseven Sedat Çiftel Ahmet Altun

https://doi.org/10.7197/cmj.1212431

Abstract

Background/Aims: To compare CTGF (connective tissue growth factor) and P2/MS [platelet count (109 / L)] 2 / [monocyte fraction (%) x segment neutrophil fraction (%)] ratio as non-invasive tests with liver biopsy in the detection of liver fibrosis. Thus, to determine whether CTGF and P2/MS index results can be used as a noninvasive marker, in the diagnosis of chronic liver disease
Materials and Methods: A total of 52 chronic hepatitis patients with concurrent liver biopsy (27 female, 25 male) were included in the study group. The subjects' ages ranged between 18 and 70, and none of the subjects had undergone liver disease-related treatment. The control group was made up of a total of 31 healthy individuals without liver disease (18 female, 13 male) from similar age groups. Liver biopsy results of patients were reported at 7 stages according to Modified Knodell Scoring (ISHAK).
Results: CTGF levels were higher in patients with chronic hepatitis (1.06±0.70 ng/ml) than the control group (0,72±0,32 ng/ml) (P<0,05). When the P2/MS indexes were compared according to the liver biopsy results of the patients in the study group, the difference was found to be significant. As the degree of fibrosis increased, P2/MS index decreased.
Conclusions: As a noninvasive test, it was seen that CTGF and P2/MS is parallel to liver biopsy in reflecting liver fibrosis. These noninvasive markers can be used where liver biopsies cannot be performed or where repetition is necessary, and in the follow-up of patients for early detection of fibrosis.

Keywords

Fibrosis, Liver, CTGF

Supporting Institution

Unit of the Cumhuriyet University Scientific Research Projects (CÜBAP)

Project Number

T533 numbered project

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