The predictive role of CA- 125 value in early stage endometrioid endometrial cancer

Begüm Kurt; İrem Küçükyıldız; Ali Yanık

doi:10.7197/cmj.1299893

EN

The predictive role of CA- 125 value in early stage endometrioid endometrial cancer

Abstract

Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial cancer for determining the cut-off values for clinicopathological factors. Study design: 161 patients were included in the study. The inclusion criteria were histopathological confirmation of endometrioid endometrial cancer and patients with CA-125 levels measured at most ten days before surgery. The association between CA-125 value and clinicopathological variables were analyzed. Receiver operating characteristic curve statistical tests with clinicopathological factors were used to determine the cut-off values and the prognostic role of CA-125. Results: The median value of CA-125 level was 15.4 (3, 2-577) IU/L. These CA-125 cut-off values ranged from 14.30 to 18.67 IU/L (sensitivity 53%– 100%, specificity 30%–59%). The statistical analysis showed a significant relation between CA-125 value and stage and pelvic-paraaortic lymph nodes metastasis. The average life expectancy of patients with CA-125 ≥15.4 was 102.8±5.9 months, whereas that of patients with CA-125 <15.4 was 120.1±3.4 months. Conclusion: Serum CA-125 levels with endometrioid endometrial cancer are related to the stage of the disease. Lower cut-off values compared to the traditional 35 IU/ml value used in ovarian cancer can be a prognostic factor in patients with endometrioid endometrial cancer.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Begüm Kurt ^*
0000-0002-7166-3130
Türkiye

İrem Küçükyıldız
0000-0002-6604-0713
Türkiye

Ali Yanık
0000-0001-9634-2117
Türkiye

Early Pub Date

June 30, 2023

Publication Date

June 30, 2023

Submission Date

May 22, 2023

Acceptance Date

June 24, 2023

Published in Issue

Year 1970 Volume: 45 Number: 2

DOI

https://doi.org/10.7197/cmj.1299893

IZ

https://izlik.org/JA77LF69LN

Cite

RIS / Bibtex

AMA

1.Kurt B, Küçükyıldız İ, Yanık A. The predictive role of CA- 125 value in early stage endometrioid endometrial cancer. CMJ. 2023;45(2):31-37. doi:10.7197/cmj.1299893

Cited By

The role of preoperative serum CA-125 levels in predicting lymph node metastasis in patients undergoing treatment for endometrial cancer

Journal of Health Sciences and Medicine

https://doi.org/10.32322/jhsm.1403151

Öz

The predictive role of CA- 125 value in early stage endometrioid endometrial cancer

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

The role of preoperative serum CA-125 levels in predicting lymph node metastasis in patients undergoing treatment for endometrial cancer