The Relationship Between Ketamine and Memory Impairment: A Systematic Review

Ghaith Al-badran

doi:10.7197/cmj.1452303

Systematic Reviews and Meta Analysis

Ketamin ve Bellek Bozuklukları Arasındaki İlişki: Bir Sistematik Derleme

Year 2024, Volume: 46 Issue: 2, 84 - 98, 29.06.2024

Ghaith Al-badran

https://doi.org/10.7197/cmj.1452303

Abstract

Ketaminin bilişsel işlevleri etkilediğine dair bulgular giderek artsa da çeşitli çalışmalarda farklı görüşler ortaya koyulmuştur. Bu çalışma, klinik uygulamalar ve halk sağlığı müdahaleleri hakkında bilgi vermede çok önemli olan Ketamin kullanımı ile bellek bozuklukları arasındaki potansiyel ilişkiyi araştırmayı amaçlamaktadır. Çalışmada sistematik derleme yöntemi benimsenerek PRISMA kılavuzuna göre altı veri tabanı taranmış, Ketamin ve bellek bozuklukları arasındaki ilişkiyi araştıran 50 çalışma analize dahil edilmiştir. Çoğu çalışma, Ketaminin bilişsel işlevler, özellikle de bellek üzerinde olumsuz bir etkisi olduğunu göstermektedir. Bazı çalışmalar cinsiyet farklılıklarını vurgulamış; ancak bunların sonuçları yetersiz kalmıştır. Çalışmalar ayrıca Ketaminin etkisinin bilişsel işlevlerle sınırlı olmadığını; depresyon, intihar düşüncesi ve nörobilişsel işlevler gibi diğer yönler üzerinde de etkili olduğunu ortaya koymuştur. Sonuç olarak Ketamin ve bellek bozuklukları arasında bir ilişki olduğu açıktır, ancak bu ilişkinin tam anlamıyla açıklanabilmesi için daha fazla çalışmaya ihtiyaç vardır.

Keywords

Biliş, Ketamin, Bellek, N-Metilaspartat

References

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The Relationship Between Ketamine and Memory Impairment: A Systematic Review

Year 2024, Volume: 46 Issue: 2, 84 - 98, 29.06.2024

Ghaith Al-badran

https://doi.org/10.7197/cmj.1452303

Abstract

Various studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports its impact. This study aimed to investigate the potential correlation between Ketamine usage and memory deterioration, which is crucial for informing clinical practice and public health interventions. A systematic review was conducted, and six databases were scanned according to the PRISMA guidelines. As a result, 50 studies were analyzed to investigate the relationship between Ketamine and memory deterioration. It was found that most studies provided evidence for the claim that there is a negative association between Ketamine and cognitive function, specifically in the realm of memory. Some studies emphasized gender differences; however, their results were inconclusive. Studies have also found that the impact of ketamine is not limited to cognitive functions; it extends to other aspects such as depression, suicidal ideation, and neurocognitive functions. In conclusion, it is evident that there is an association between Ketamine and memory deterioration however, this relationship is challenging to develop and further studies are required.

Keywords

Cognition, Ketamine, Memory, N-Methylaspartate

Ethical Statement

Ethics committee approval is not required for review articles.

References

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8. Pham TH, Gardier AM. Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies. Pharmacology & therapeutics. 2019;199:58-90.
9. Stone JM, Dietrich C, Edden R, Mehta MA, De Simoni S, Reed LJ, et al. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Molecular psychiatry. 2012;17(7):664-5.
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17. Morgan CJ, Dodds CM, Furby H, Pepper F, Fam J, Freeman TP, et al. Long-term heavy ketamine use is associated with spatial memory impairment and altered hippocampal activation. Frontiers in psychiatry. 2014;5:149.
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25. Chen WY, Huang MC, Lin SK. Gender differences in subjective discontinuation symptoms associated with ketamine use. Substance Abuse Treatment Prevention and Policy. 2014;9.
26. Cheng WJ, Chen CH, Chen CK, Huang MC, Pietrzak RH, Krystal JH, et al. Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. Schizophrenia Research. 2018;199:313-8.
27. D'Souza DC, Ahn K, Bhakta S, Elander J, Singh N, Nadim H, et al. Nicotine Fails to Attenuate Ketamine-Induced Cognitive Deficits and Negative and Positive Symptoms in Humans: Implications for Schizophrenia. Biological Psychiatry. 2012;72(9):785-94.
28. D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH, et al. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry. 2018;84(6):413-21.
29. Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, et al. The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology. 2013;38(13):2613-22.
30. Fernie G, Currie J, Perrin JS, Stewart CA, Anderson V, Bennett DM, et al. Ketamine as the anaesthetic for electroconvulsive therapy: the KANECT randomised controlled trial. British Journal of Psychiatry. 2017;210(6):422-+.
31. Greer A, Treston G. Factors associated with patient-reported procedural memory following emergency department procedural sedation with ketamine and propofol: A prospective cohort of 563 patients. Emergency Medicine Australasia. 2018;30(2):200-8.
32. Khalili-Mahani N, Niesters M, van Osch MJ, Oitzl M, Veer I, de Rooij M, et al. Ketamine interactions with biomarkers of stress: A randomized placebo-controlled repeated measures resting-state fMRI and PCASL pilot study in healthy men. NeuroImage. 2015;108:396-409.
33. Klausen N-O, JØRGENSEN FW, Chraemmer-Jørgensen B. Psychomimetic reactions after low-dose ketamine infusion: comparison with neuroleptanaesthesia. British Journal of Anaesthesia. 1983;55(4):297-301.
34. Krupitsky EM, Burakov AM, Romanova TN, Grinenko NI, Grinenko AY, Fletcher J, et al. Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: Psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Neuropsychopharmacology. 2001;25(6):936-47.
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Details

Primary Language	English
Subjects	Mental Health Services, Health Services and Systems (Other)
Journal Section	Reviews
Authors	Ghaith Al-badran 0000-0002-9388-2078
Publication Date	June 29, 2024
Submission Date	March 16, 2024
Acceptance Date	May 21, 2024
Published in Issue	Year 2024Volume: 46 Issue: 2

Cite

AMA	Al-badran G. The Relationship Between Ketamine and Memory Impairment: A Systematic Review. CMJ. June 2024;46(2):84-98. doi:10.7197/cmj.1452303

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