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Yıl 2019, Cilt: 41 Sayı: 1, 1 - 9, 28.03.2019

Sevgi Durna Taştan Parham Taslimi Fatih Gürses Recep Akkaya , Faik Gökalp İlhami Gülçin

https://doi.org/10.7197/223.vi.515249

Öz

Kaynakça

  • Knave B (2001) Electromagnetic fields and health outcomes. Ann Acad Med Singapore 30 (5):489-93.Habash RW, Elwood JM, Krewski D, Lotz WG, McNamee JP, Prato FS (2009) Recent advances in research on radiofrequency fields and health: 2004-2007. J Toxicol Environ Health B Crit Rev. 12 (4): 250-88.Cotgreave IA (2005) Biological stress responses to radio frequency electromagnetic radiation: are mobile phones really so (heat) shocking? Arch Biochem Biophys. 1; 435 (1): 227-40.Czyz JI, Guan K, Zeng Q, Nikolova T, Meister A, Schönborn F, Schuderer J, Kuster N. & Wobus A.M. (2004) High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics, 25:4 296-307.Nikolova T, Czyz JI, Rolletschek A, Blyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus AM. (2005) Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells. FASEB J. 19 (12):1686-8.Bartsch H, Bartsch C, Seebald E, Deerberg F, Dietz K, Vollrath L, Mecke D. (2002) Chronic exposure to a GSM-like signal (mobile phone) does not stimulate the development of DMBA-induced mammary tumors in rats: results of three consecutive studies. Radiat Res. 157 (2):183-90.Avendaño C, Mata A, Sanchez Sarmiento CA, Doncel GF. (2012) Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation. Fertil Steril. 97 (1):39-45 Poulletier de Gannes F, Billaudel B, Haro E, Taxile M, Le Montagner L, Hurtier A, Ait Aissa S, Masuda H, Percherancier Y, Ruffié G, Dufour P, Veyret B, Lagroye I. (2012) Rat fertility and embryo fetal development: influence of exposure to the Wi-Fi signal. Reprod Toxicol. 36: 1-5.Skakkebaek NE, Jørgensen N, Main KM, Rajpert-De Meyts E, Leffers H, Andersson AM, Juul A, Carlsen E, Mortensen GK, Jensen TK, Toppari J. (2006) Is human fecundity declining?. Int J Androl. 29 (1): 2-11.Deepinder F, Makker K, Agarwal A. (2007) Cell phones and male infertility: dissecting the relationship. Reprod Biomed Online. 15 (3): 266-70.Kundi M, Mild K, Hardell L, Mattsson MO. (2004) Mobile telephones and cancer--a review of epidemiological evidence. J Toxicol Environ Health B Crit Rev. 7 (5): 351-84.Pourlis AF, (2009) Reproductive and developmental effects of EMF in vertebrate animal models. Pathophysiology. 16 (2-3): 179-89.La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. (2012) Diabetes mellitus and sperm parameters. J Androl. 33 (2): 145-53. (a)La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. (2012) High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia. 1: 438-46. (b)Imai N, Kawabe M, Hikage T, Nojima T, Takahashi S, Shirai T. (2011) Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones. Syst Biol Reprod Med. 57 (4): 204-9.Ribeiro EP, Rhoden EL, Horn MM, Rhoden C, Lima LP, Toniolo L. (2007) Effects of subchronic exposure to radio frequency from a conventional cellular telephone on testicular function in adult rats. J Urol. 177 (1): 395-9.Lee HJ, Pack JK, Kim TH, Kim N, Choi SY, Lee JS, Kim SH, Lee YS. (2010) The lack of histological changes of CDMA cellular phone-based radio frequency on rat testis. Bioelectromagnetics. 31 (7): 528-34Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, Yegin D. (2008) Mobile phone exposure does not induce apoptosis on spermatogenesis in rats. Arch Med Res. 39 (1): 40-4.Dasdag S, Ketani MA, Akdag Z, Ersay AR, Sari I, Demirtas OC, Celik MS. (1999) Whole-body microwave exposure emitted by cellular phones and testicular function of rats. Urol Res. 27 (3): 219-23.Berg JM, Tymoczko JL, Stryer L, 2014. Biyokimya. Palme Yayıncılık. P, 241-247, Ankara.Gocer H, Topal F, Topal M, Küçük M, Teke D, Gülçin İ, Alwasel SH, Supuran CT, (2016) Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. J Enzyme Inhib Med Chem. 31 (3): 441-7.Kocyigit UM, Aslan ON, Gulcin I, Temel Y, Ceylan M. (2016) Synthesis and Carbonic Anhydrase Inhibition of Novel 2-(4-(Aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Derivatives. Arch Pharm (Weinheim). 349 (12): 955-963. Gul H, Mete E, Taslimi P, Gulcin I, Supuran CT. (2016) Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines. J Enzyme Inhib Med Chem. 32 (1): 189-192. Kocyigit UM, Budak Y, Gürdere MB, Ertürk F, Yencilek B, Taslimi P, Gülçin İ, Ceylan M. (2018) Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles. Arch Physiol Biochem. 124 (1): 61-68.Bhatt, A., Mahon, B. P., Cruzeiro, V. W. D., Cornelio, B., Laronze Cochard, M., Ceruso, M., & Roitberg, A. (2017). Structure–activity relationships of benzenesulfonamide based inhibitors towards carbonic anhydrase isoform specificity. Chembiochem, 18(2), 213-222.Akıncıoğlu A, Topal M, Gülçin I, Göksu S. (2014) Novel sulphamides and sulphonamides incorporating the tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Arch Pharm (Weinheim). 347 (1): 68-76. Göçer H, Akincioğlu A, Göksu S, Gülçin İ, Supuran CT. (2014) Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. J Enzyme Inhib Med Chem. 30 (2): 316-20. Kose LP, Gülçin İ, Goren AC, Namiesnik J, Martinez-Ayala AL, Gorinstein S. LC-MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes. Ind Crops Prod 2015;74:712-21.Özbey F, Taslimi P, Gülçin İ, Maraş A, Göksu S, Supuran CT. (2016) Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. J Enzyme Inhib Med Chem. 31; 79-85.Taslimi P, Gulcin I, Ozgeris B, Goksu S, Tumer F, Alwasel SH, Supuran CT. (2016) The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives. J Enzyme Inhib Med Chem. 31 (1): 152-7. Scozzafava A, Kalın P, Supuran CT, Gülçin İ, Alwasel SH. (2015) The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII). J Enzyme Inhib Med Chem. 30 (6): 941-6. Gülçin I, Beydemir S, Büyükokuroğlu ME. (2004) In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biol Pharm Bull. 27 (5): 613-6.Aksu K, Özgeriş B, Taslimi P, Naderi A, Gülçin İ, Göksu S. (2016) Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Arch Pharm (Weinheim). 349 (12): 944-954. Coban TA, Beydemir Ş, Gülçin İ, Ekinci D, (2007) Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biological and Pharmaceutical Bulletin 30 (12), 2257-2261Kucukoglu K, Oral F, Aydin T, Yamali C, Algul O, Sakagami H, Gulcin I, Supuran CT, Gul HI. (2016) Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines. J Enzyme Inhib Med Chem. 31 4: 20-24. Gul HI, Tugrak M, Sakagami H, Taslimi P, Gulcin I, (2016) Supuran CT5. Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. J Enzyme Inhib Med Chem. 31 (6): 1619-24.Gülçin I, Beydemir S, Büyükokuroğlu ME. (2004) In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biol Pharm Bull. 27 (5): 613-6.Atasoy HI, Gunal MY, Atasoy P, Elgun S, Bugdayci G.(2013) Immunohistopathologic demonstration of deleterious effects on growing rat testes of radiofrequency waves emitted from conventional Wi-Fi devices. J Pediatr Urol. 9 (2): 223-9.Lönn S, Forssén U, Vecchia P, Ahlbom A, Feychting M. (2004) Output power levels from mobile phones in different geographical areas; implications for exposure assessment. Occup Environ Med. 61 (9): 769-72.Cairnie A. B. and Harding. R. K. (1981) Cytological Studies in Mouse Testis Irradiated with 2.45-GHz Continuous-Wave Microwaves. Radiation Research. 87 (1): 100-108.Ono T, Saito Y, Komura J, Ikehata H, Tarusawa Y, Nojima T, Goukon K, Ohba Y, Wang J, Fujiwara O, Sato R. (2004) Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero. Tohoku J Exp Med. 202 (2): 93-103.Kilgallon SJ, Simmons LW. (2005) Image content influences men's semen quality. Biol Lett. 22; 1(3): 253-5.Makker K, Agarwal A, Sharma R.(2009) Oxidative stress & male infertility. Indian J Med Res. 129 (4): 357-67.Tunc O, Tremellen K. (2009) Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet. 26 (9-10): 537-44Akıncıoğlu A, Kocaman E, Akıncıoğlu H, Salmas RE, Durdagi S, Gülçin İ, Supuran CT, Göksu S. (2017) The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. Bioorg Chem. 74:238-250. Gulçin İ, Abbasova M, Taslimi P, Huyut Z, Safarova L, Sujayev A, Farzaliyev V, Beydemir Ş, Alwasel SH, Supuran CT. (2017) Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors. J Enzyme Inhib Med Chem. 32 (1): 1174-1182.Ekinci Akdemir FN, Albayrak M, Çalik M, Bayir Y, Gülçin İ. (2017) The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin. Biomedicines. 28; 5 (2).

The effects of wireless on carbonic anhydrase and acetylcholinesterase enzyme activities in some tissues related to respiratory, excretory and reproductive systems of rats

Yıl 2019, Cilt: 41 Sayı: 1, 1 - 9, 28.03.2019

Sevgi Durna Taştan Parham Taslimi Fatih Gürses Recep Akkaya , Faik Gökalp İlhami Gülçin

https://doi.org/10.7197/223.vi.515249

Öz

The aim of our studies is to assist in understanding the effects of
wireless electromagnetic waves on activities of carbonic anhydrase (CA) and
acetylcholinesterase (AChE) enzymes in the different tissues related to respiratory,
excretory and reproductive systems of the wistar albino rats. For this respect, 2 different groups each of which contains 8
rats (n = 8) were formed as control group and wireless electromagnetic wave
administered groups. The rats were necropsied and the different tissues of the
rats were extracted. Activities of carbonic anhydrase and acetylcholinesterase
enzymes were measured for each tissue by using the hydratase, esterase and
acetylcholinioidide methods. All the experimental results were provided in mean ± standard deviation (±SD). Statistical significance
was identified to be p<0.05.  It was observed that there were
significant decreases of enzyme activities in wireless administered group in
brain, spleen, kidney, and trachea tissues according to CA and AChE levels.

Anahtar Kelimeler

Wireless Electromagnetic Fields; Acetylcholinesterase; Carbonic anhydrase; Enzyme activity; Rat

Kaynakça

  • Knave B (2001) Electromagnetic fields and health outcomes. Ann Acad Med Singapore 30 (5):489-93.Habash RW, Elwood JM, Krewski D, Lotz WG, McNamee JP, Prato FS (2009) Recent advances in research on radiofrequency fields and health: 2004-2007. J Toxicol Environ Health B Crit Rev. 12 (4): 250-88.Cotgreave IA (2005) Biological stress responses to radio frequency electromagnetic radiation: are mobile phones really so (heat) shocking? Arch Biochem Biophys. 1; 435 (1): 227-40.Czyz JI, Guan K, Zeng Q, Nikolova T, Meister A, Schönborn F, Schuderer J, Kuster N. & Wobus A.M. (2004) High frequency electromagnetic fields (GSM signals) affect gene expression levels in tumor suppressor p53-deficient embryonic stem cells. Bioelectromagnetics, 25:4 296-307.Nikolova T, Czyz JI, Rolletschek A, Blyszczuk P, Fuchs J, Jovtchev G, Schuderer J, Kuster N, Wobus AM. (2005) Electromagnetic fields affect transcript levels of apoptosis-related genes in embryonic stem cell-derived neural progenitor cells. FASEB J. 19 (12):1686-8.Bartsch H, Bartsch C, Seebald E, Deerberg F, Dietz K, Vollrath L, Mecke D. (2002) Chronic exposure to a GSM-like signal (mobile phone) does not stimulate the development of DMBA-induced mammary tumors in rats: results of three consecutive studies. Radiat Res. 157 (2):183-90.Avendaño C, Mata A, Sanchez Sarmiento CA, Doncel GF. (2012) Use of laptop computers connected to internet through Wi-Fi decreases human sperm motility and increases sperm DNA fragmentation. Fertil Steril. 97 (1):39-45 Poulletier de Gannes F, Billaudel B, Haro E, Taxile M, Le Montagner L, Hurtier A, Ait Aissa S, Masuda H, Percherancier Y, Ruffié G, Dufour P, Veyret B, Lagroye I. (2012) Rat fertility and embryo fetal development: influence of exposure to the Wi-Fi signal. Reprod Toxicol. 36: 1-5.Skakkebaek NE, Jørgensen N, Main KM, Rajpert-De Meyts E, Leffers H, Andersson AM, Juul A, Carlsen E, Mortensen GK, Jensen TK, Toppari J. (2006) Is human fecundity declining?. Int J Androl. 29 (1): 2-11.Deepinder F, Makker K, Agarwal A. (2007) Cell phones and male infertility: dissecting the relationship. Reprod Biomed Online. 15 (3): 266-70.Kundi M, Mild K, Hardell L, Mattsson MO. (2004) Mobile telephones and cancer--a review of epidemiological evidence. J Toxicol Environ Health B Crit Rev. 7 (5): 351-84.Pourlis AF, (2009) Reproductive and developmental effects of EMF in vertebrate animal models. Pathophysiology. 16 (2-3): 179-89.La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. (2012) Diabetes mellitus and sperm parameters. J Androl. 33 (2): 145-53. (a)La Vignera S, Condorelli R, Vicari E, D'Agata R, Calogero AE. (2012) High frequency of sexual dysfunction in patients with male accessory gland infections. Andrologia. 1: 438-46. (b)Imai N, Kawabe M, Hikage T, Nojima T, Takahashi S, Shirai T. (2011) Effects on rat testis of 1.95-GHz W-CDMA for IMT-2000 cellular phones. Syst Biol Reprod Med. 57 (4): 204-9.Ribeiro EP, Rhoden EL, Horn MM, Rhoden C, Lima LP, Toniolo L. (2007) Effects of subchronic exposure to radio frequency from a conventional cellular telephone on testicular function in adult rats. J Urol. 177 (1): 395-9.Lee HJ, Pack JK, Kim TH, Kim N, Choi SY, Lee JS, Kim SH, Lee YS. (2010) The lack of histological changes of CDMA cellular phone-based radio frequency on rat testis. Bioelectromagnetics. 31 (7): 528-34Dasdag S, Akdag MZ, Ulukaya E, Uzunlar AK, Yegin D. (2008) Mobile phone exposure does not induce apoptosis on spermatogenesis in rats. Arch Med Res. 39 (1): 40-4.Dasdag S, Ketani MA, Akdag Z, Ersay AR, Sari I, Demirtas OC, Celik MS. (1999) Whole-body microwave exposure emitted by cellular phones and testicular function of rats. Urol Res. 27 (3): 219-23.Berg JM, Tymoczko JL, Stryer L, 2014. Biyokimya. Palme Yayıncılık. P, 241-247, Ankara.Gocer H, Topal F, Topal M, Küçük M, Teke D, Gülçin İ, Alwasel SH, Supuran CT, (2016) Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. J Enzyme Inhib Med Chem. 31 (3): 441-7.Kocyigit UM, Aslan ON, Gulcin I, Temel Y, Ceylan M. (2016) Synthesis and Carbonic Anhydrase Inhibition of Novel 2-(4-(Aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione Derivatives. Arch Pharm (Weinheim). 349 (12): 955-963. Gul H, Mete E, Taslimi P, Gulcin I, Supuran CT. (2016) Synthesis, carbonic anhydrase I and II inhibition studies of the 1,3,5-trisubstituted-pyrazolines. J Enzyme Inhib Med Chem. 32 (1): 189-192. Kocyigit UM, Budak Y, Gürdere MB, Ertürk F, Yencilek B, Taslimi P, Gülçin İ, Ceylan M. (2018) Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles. Arch Physiol Biochem. 124 (1): 61-68.Bhatt, A., Mahon, B. P., Cruzeiro, V. W. D., Cornelio, B., Laronze Cochard, M., Ceruso, M., & Roitberg, A. (2017). Structure–activity relationships of benzenesulfonamide based inhibitors towards carbonic anhydrase isoform specificity. Chembiochem, 18(2), 213-222.Akıncıoğlu A, Topal M, Gülçin I, Göksu S. (2014) Novel sulphamides and sulphonamides incorporating the tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Arch Pharm (Weinheim). 347 (1): 68-76. Göçer H, Akincioğlu A, Göksu S, Gülçin İ, Supuran CT. (2014) Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates. J Enzyme Inhib Med Chem. 30 (2): 316-20. Kose LP, Gülçin İ, Goren AC, Namiesnik J, Martinez-Ayala AL, Gorinstein S. LC-MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes. Ind Crops Prod 2015;74:712-21.Özbey F, Taslimi P, Gülçin İ, Maraş A, Göksu S, Supuran CT. (2016) Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. J Enzyme Inhib Med Chem. 31; 79-85.Taslimi P, Gulcin I, Ozgeris B, Goksu S, Tumer F, Alwasel SH, Supuran CT. (2016) The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives. J Enzyme Inhib Med Chem. 31 (1): 152-7. Scozzafava A, Kalın P, Supuran CT, Gülçin İ, Alwasel SH. (2015) The impact of hydroquinone on acetylcholine esterase and certain human carbonic anhydrase isoenzymes (hCA I, II, IX, and XII). J Enzyme Inhib Med Chem. 30 (6): 941-6. Gülçin I, Beydemir S, Büyükokuroğlu ME. (2004) In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biol Pharm Bull. 27 (5): 613-6.Aksu K, Özgeriş B, Taslimi P, Naderi A, Gülçin İ, Göksu S. (2016) Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Arch Pharm (Weinheim). 349 (12): 944-954. Coban TA, Beydemir Ş, Gülçin İ, Ekinci D, (2007) Morphine inhibits erythrocyte carbonic anhydrase in vitro and in vivo. Biological and Pharmaceutical Bulletin 30 (12), 2257-2261Kucukoglu K, Oral F, Aydin T, Yamali C, Algul O, Sakagami H, Gulcin I, Supuran CT, Gul HI. (2016) Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines. J Enzyme Inhib Med Chem. 31 4: 20-24. Gul HI, Tugrak M, Sakagami H, Taslimi P, Gulcin I, (2016) Supuran CT5. Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. J Enzyme Inhib Med Chem. 31 (6): 1619-24.Gülçin I, Beydemir S, Büyükokuroğlu ME. (2004) In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biol Pharm Bull. 27 (5): 613-6.Atasoy HI, Gunal MY, Atasoy P, Elgun S, Bugdayci G.(2013) Immunohistopathologic demonstration of deleterious effects on growing rat testes of radiofrequency waves emitted from conventional Wi-Fi devices. J Pediatr Urol. 9 (2): 223-9.Lönn S, Forssén U, Vecchia P, Ahlbom A, Feychting M. (2004) Output power levels from mobile phones in different geographical areas; implications for exposure assessment. Occup Environ Med. 61 (9): 769-72.Cairnie A. B. and Harding. R. K. (1981) Cytological Studies in Mouse Testis Irradiated with 2.45-GHz Continuous-Wave Microwaves. Radiation Research. 87 (1): 100-108.Ono T, Saito Y, Komura J, Ikehata H, Tarusawa Y, Nojima T, Goukon K, Ohba Y, Wang J, Fujiwara O, Sato R. (2004) Absence of mutagenic effects of 2.45 GHz radiofrequency exposure in spleen, liver, brain, and testis of lacZ-transgenic mouse exposed in utero. Tohoku J Exp Med. 202 (2): 93-103.Kilgallon SJ, Simmons LW. (2005) Image content influences men's semen quality. Biol Lett. 22; 1(3): 253-5.Makker K, Agarwal A, Sharma R.(2009) Oxidative stress & male infertility. Indian J Med Res. 129 (4): 357-67.Tunc O, Tremellen K. (2009) Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet. 26 (9-10): 537-44Akıncıoğlu A, Kocaman E, Akıncıoğlu H, Salmas RE, Durdagi S, Gülçin İ, Supuran CT, Göksu S. (2017) The synthesis of novel sulfamides derived from β-benzylphenethylamines as acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase enzymes inhibitors. Bioorg Chem. 74:238-250. Gulçin İ, Abbasova M, Taslimi P, Huyut Z, Safarova L, Sujayev A, Farzaliyev V, Beydemir Ş, Alwasel SH, Supuran CT. (2017) Synthesis and biological evaluation of aminomethyl and alkoxymethyl derivatives as carbonic anhydrase, acetylcholinesterase and butyrylcholinesterase inhibitors. J Enzyme Inhib Med Chem. 32 (1): 1174-1182.Ekinci Akdemir FN, Albayrak M, Çalik M, Bayir Y, Gülçin İ. (2017) The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin. Biomedicines. 28; 5 (2).
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Temel Tıp Bilimleri Araştırma Yazıları
Yazarlar

Sevgi Durna Taştan

Parham Taslimi

Fatih Gürses

Recep Akkaya

Faik Gökalp

İlhami Gülçin

Yayımlanma Tarihi 28 Mart 2019
Kabul Tarihi 26 Mart 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 41 Sayı: 1

Kaynak Göster

AMA Taştan SD, Taslimi P, Gürses F, Akkaya R, Gökalp F, Gülçin İ. The effects of wireless on carbonic anhydrase and acetylcholinesterase enzyme activities in some tissues related to respiratory, excretory and reproductive systems of rats. CMJ. Mart 2019;41(1):1-9. doi:10.7197/223.vi.515249