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Analyzing The Relationship Between Systemic Inflammatory Index, Neutrophil Lymphocyte Ratios And Covid-19 Infection

Yıl 2023, Cilt: 45 Sayı: 2, 67 - 73, 30.06.2023

Hayri Canbaz , Neslihan Ergün Süzer , Özgür Sirkeci , Emel Erkuş Sirkeci

https://doi.org/10.7197/cmj.1238446

Öz

Introduction: There are important parameters in understanding the severity of COVID-19 infection. We aimed to observe the role of systemic inflammatory index and neutrophil lymphocyte ratios in Covid-19 infections and the changes seen during the infection process.
Method: This retrospective single-center study was conducted between April 2020 and May 2020. Clinical, demographic and laboratory data of patients with COVID-19 were analyzed. All COVID-19 case confirmation made with reverse transcription polymerase chain reaction. Neutrophil/lymphocyte ratio and SII change and relationship were examined.
Results: 140 patients were included in our study and 50 of them were female. There was no statistically significant difference in SII according to gender (p>0.05) but there was a difference in SII between age categories (p=0.009). A statistically significant difference was found (p=0.003) regardless of the presence of comorbidities. Tobacco users had a significantly lower SII (p=0.028). A statistically significant difference was found between SII and Covid Severity Index (p=0.020). A statistically significant difference was found in the SII values of those receiving favipiravir treatment and those receiving hydroxychloroquine treatment (p<0.001). A statistically significant difference was found between those who received treatment in the outpatient clinic and those who received treatment in the intensive care unit (p=0.043). A statistically significant difference in the SII values was found between the patients who died and those who survived (p= 0.009).

Conclusion: The Systemic Inflammatory Index is a parameter that can be used for the Covid-19 patient follow-up and estimating mortality.

Anahtar Kelimeler

Covid-19 Emergency Medicine Systemic Inflammatory Index Neutrophil Lymphocyte Ratio

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

-

Kaynakça

  • 1. Fois AG, Paliogiannis P. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020;4;25(23):5725.
  • 2. World Health Organization. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 106, https://www.who.int/emergencies/diseases/ novel-coronavirus-2019/situation-reports (2021)
  • 3. Süzer NE, Sirkeci EE, Sirkeci O. Are basic inflammation markers sufficient for predicting Covid 19 infection, Acta Medica Mediterranea. 2021;37(2):1127-1131.
  • 4. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
  • 5. Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol. Infect. 2020;148:e139. 6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–1242.
  • 7. Wang D, Hu B, Hu C et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;17;323(11):1061-1069.
  • 8. Zhou F, Yu T, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062.
  • 9. Usul E, San I, Bekgoz B, Sahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark. Med. 2020;14:1207–1215.
  • 10. Paliogiannis P, Fois AG, Sotgia S et al. The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: A systematic review and meta-analysis. Eur. J. Clin. Investig. 2018;48:e12984.
  • 11. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91: 181-4.

Sistemik İnflamatuar İndeks Ve Nötrofil Lenfosit Oranlarının Covid-19 Enfeksiyonu İle İlişkilerinin Analizi

Yıl 2023, Cilt: 45 Sayı: 2, 67 - 73, 30.06.2023

Hayri Canbaz , Neslihan Ergün Süzer , Özgür Sirkeci , Emel Erkuş Sirkeci

https://doi.org/10.7197/cmj.1238446

Öz

Giriş: COVID-19 enfeksiyonunun ciddiyetini anlamada önemli parametreler bulunmaktadır. Çalışmamızda amacımız Sistemik inflamatuar index (SII) ve nötrofil lenfosit oranlarının Covid-19 Enfeksiyonu ve bu enfeksiyon sürecindeki değişim ile ilişkilerini ortaya koymaktır.
Method: Nisan 2020-Mayıs 2020 tarihleri arasında yapılan retrospektif tek merkezli bir çalışmadır. COVID-19 hastalığı tüm vakalarda ters transkripsiyon polimeraz zincir reaksiyonu ile doğrulanan hastaların demografik, klinik ve laboratuvar verileri incelendi. Nötrofil/lenfosit oranı ve SII değişimi ve ilişkisi incelendi.

Bulgular: Çalışmamızda 50’si kadın toplam 140 hasta bulunmaktadır. İstatistiksel olarak Cinsiyetlere göre SII ‘de farklılık bulunmaz iken (p>0.05), yaş katagorileri arasında SII ‘de anlamlı farklılık saptanmıştır (p=0,009). Komorbidite olup olmaması durumunda, SII ‘de istatistiksel anlamlı farklılıklar saptandı (p=0,003). Tütün kullananların SII nin daha az olduğu ve bunun anlamlı olduğu bulundu (p=0.028). SII ile Covid Severity İndexin, karşılaştırılmasında; gruplar arası istatistiksel anlamlı farklılık bulundu (p=0.020). Favipravir tedavisi alanlar ile hidroksiklorokin tedavisi alanların SII değerlerinde istatistiksel anlamlı farklılık bulundu (p<0.001). Klinikte tedavi alanlar ile yoğun bakımda tedavi alanlar arasında istatistiksel olarak anlamlı farklılık bulundu (p=0,043) Hastalardan ölenlerin ve yaşayanların SII’lerinin gruplar arasında istatistiksel olarak anlamlı farklılık bulundu (p= 0.009).
Sonuç: Sistemik İnflamatuar İndeks, Covid-19 hastalarının takibinde ve mortalite tahminlerinde kullanılabilir bir parametredir.

Anahtar Kelimeler

Acil Servis Sistemik İnflamatuvar İndeks Covid-19 Covid-19 Nötrofil Lenfosit Oranı

Proje Numarası

yok

Kaynakça

  • 1. Fois AG, Paliogiannis P. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020;4;25(23):5725.
  • 2. World Health Organization. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 106, https://www.who.int/emergencies/diseases/ novel-coronavirus-2019/situation-reports (2021)
  • 3. Süzer NE, Sirkeci EE, Sirkeci O. Are basic inflammation markers sufficient for predicting Covid 19 infection, Acta Medica Mediterranea. 2021;37(2):1127-1131.
  • 4. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
  • 5. Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol. Infect. 2020;148:e139. 6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–1242.
  • 7. Wang D, Hu B, Hu C et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;17;323(11):1061-1069.
  • 8. Zhou F, Yu T, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062.
  • 9. Usul E, San I, Bekgoz B, Sahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark. Med. 2020;14:1207–1215.
  • 10. Paliogiannis P, Fois AG, Sotgia S et al. The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: A systematic review and meta-analysis. Eur. J. Clin. Investig. 2018;48:e12984.
  • 11. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91: 181-4.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Cerrahi Tıp Bilimleri Araştırma Yazıları
Yazarlar

Hayri Canbaz 0000-0001-6989-7854

Neslihan Ergün Süzer 0000-0003-4839-8110

Özgür Sirkeci 0000-0001-9048-5096

Emel Erkuş Sirkeci 0000-0003-2743-7619

Proje Numarası yok
Erken Görünüm Tarihi 30 Haziran 2023
Yayımlanma Tarihi 30 Haziran 2023
Kabul Tarihi 9 Haziran 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 45 Sayı: 2

Kaynak Göster

AMA Canbaz H, Ergün Süzer N, Sirkeci Ö, Erkuş Sirkeci E. Analyzing The Relationship Between Systemic Inflammatory Index, Neutrophil Lymphocyte Ratios And Covid-19 Infection. CMJ. Haziran 2023;45(2):67-73. doi:10.7197/cmj.1238446
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