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Examination of Subclinical Neurological Involvement in Patients with Psoriasis Vulgaris

Yıl 2024, Cilt: 46 Sayı: 3, 169 - 177, 30.09.2024

Sibel Berksoy Hayta , Burhanettin Çiğdem , Rukiye Guner , Şeyda Figül Gökçe , Melih Akyol

https://doi.org/10.7197/cmj.1424299

Öz

Background : The aim of this study is to evaluate cognitive functions of patients with psoriasis in terms of subclinical neurological involvement using p300 method, and to reveal the correlation between the disease duration and severity if any.
Methods: 40 patients with psoriasis vulgaris and 40 healthy individuals were included in the study. Standard mini mental test and beck depression inventory were applied to the groups. PASI values and DLQI values of psoriasis patients were calculated. P300 measurements of both groups were recorded and assessed in order to evaluate the cognitive functions.
Results: There was no statistically significant difference between the healthy and psoriasis groups in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.681, p=0.301, p=0.138, p=0.739, respectively). When it was compared in terms of PASI values, there was no statistically significant difference in the patient group in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.211, p=0.422, p=0.106, p=0.305, respectively). When evaluated according to disease duration, there was no statistically significant difference between the groups in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.901, p=0.244, p=0.632, p=0.868, respectively).
Conclusion: Cognitive functions in psoriasis patients are not affected by the presence, severity and duration of the disease. As far as we know, the present study is the first study using electrophysiological P300 method in evaluating the cognitive functions in patients with psoriasis.

Anahtar Kelimeler

Psoriasis cognition P300 neurophysiological test cognitive dysfunction

Etik Beyan

Cumhuriyet University Clinical Research Ethics Committee (2017-01/24).

Destekleyen Kurum

CUBAP

Proje Numarası

T764.

Kaynakça

  • 1. Akyol M, Alper S, Atakan N, Bülbül Başkan E, Gürer MA, Koç E, Onsun N, Ozarmagan G, Şentürk N, Yaylı S. Turkey Psoriasis Treatment Guide-2016. Türkderm- Arch Turk Dermatol Venerology. 2016;50(1):1-56.
  • 2. Bu J, Ding R, Zhou L, Chen X, Shen E. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front. Immunol. 2022;13: 880201.
  • 3. Amanat M, Salehi M, Rezaei N. Neurological and psychiatric disorders in psoriasis. Rev Neurosci. 2018; 29(7):805-13.
  • 4. Biçici F, Berksoy Hayta S, Akyol M, Özçelik S, Ziynet Çınar Z. Evaluation of sleep quality in patients with psoriasis. Türkderm- Arch Turk Dermatol Venerology. 2015; 49: 208-12.
  • 5. Berksoy Hayta S, Güner R, Akyol M, Albayrak F, Kuğu N, Özçelik S. Increased expressed emotion in patients with psoriasis. Neuropsychiatria and Neuropsychologia. 2018: 13(1);9-16.
  • 6. Bettcher BM, Kramer JH. Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini-Review. Clin Pharmacol Ther. 2014; 96(4): 464-9.
  • 7. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 2000; 908:244-54.
  • 8. Eikelenboom P, Hoozemans JJ, Veerhuis R, van Exel E, Rozemuller AJ, van Gool WA. Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer’s disease. Alzheimers Res Ther. 2012;4:15.
  • 9. Kravitz BA, Corrada MM, Kawas CH. Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Alzheimers Dement. 2009;5:318-23.
  • 10. Bettcher BM, Wilheim R, Rigby T, Green R, Miller JW, Racine CA, Yaffe K, Miller BL, Kramer JH. C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav Immun. 2012;26:103-8.
  • 11. Çölgeçen E, Çelikbilek A, Taslak Keskin D. Cognitive Impairment in Patients with Psoriasis: A Cross-Sectional Study Using the Montreal Cognitive Assessment. Am J Clin Dermatol. 2016;17:413-9.
  • 12. Pezzolo E, Mutlu U, Vernooij MW, Dowlatshahi EA, Gisondi P, Girolomoni G, Tamar Nijsten T, Ikram A, Wakkee M. Psoriasis is not associated with cognition, brain imaging markers and risk of dementia: the Rotterdam Study. 10.1016/j.jaad.2018.07.046
  • 13. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, Culliford D, Perry VH. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 2009;73(10):768-74.
  • 14. Gisondi P, Sala F, Alessandrini F, Avesani V, Zoccatelli G, Beltramello A, Moretto G, Gambina G, Girolomoni G. Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis. Dermatology.2014;228(1):78-85.
  • 15. Marek-Jozefowicz L, Jaracz M, Placek W, Czajkowski R, Borkowska A. Cognitive impairment in patients with severe psoriasis. Adv Dermatol Allergol. 2017;34(2):120-5.
  • 16. Langley RG, Ellis CN. Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment and Lattice System Physicans Global Assessment. J Am Acad Dermatol. 2004;51:563-9.
  • 17. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Reliability and Validity of The Standardized Mini Mental State Examination in The Diagnosis of Mild Dementia in Turkish Population. Türk Psikiyatri Dergisi. 2002; 13(4):273-81.
  • 18. Hisli N. Validity and reliability of Beck depression inventory for university students. Back depresyon envanterinin üniversite öğrencileri için geçerliği, güvenirliği.Turkish Journal of Psychology . 1989;7:3-13.
  • 19. Öztürkcan S, Ermertcan A, Eser E, Şahin MT. Cross validation of Turkish version of Dermatology Life Quality Index (DLQI). International Journal of Dermatology. 2006;45(11):1300-7.
  • 20. Gökçay F, Celebisoy N, Kisabay A, Kumral E, Akyürekli O. P300 and neuropsychological evaluation in Behçet’s disease with and without neurological manifestations. J Neurol. 2004;251 :676-9.
  • 21. Keçeci H, Akyol M. P300 in Behcet's Patients without Neurological Manifestations. The Canadian journal of neurological sciences. 2001; 28(1):66-9.
  • 22. Melynyte S, Wang GY, Griskova-Bulanova I. Gender effect on auditory P300: A systematic review. International Journal of Psychophsiology. 2018;133:55-65.
  • 23. Imamoglu B, Berksoy Hayta S, Guner R, Akyol M, Ozcelik S. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atheroscler Dis. 2016;1(1):e158–e161.
  • 24. Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol 2006; 55: 829-35.
  • 25. Innamorati M, Quinto RM, Lester D, Iani L, Graceffa D, Bonifati C. Cognitive impairment in patients with psoriasis: A matched case-control study. J Psychosom Res. 2018;105:99-105.
  • 26. Panasiti MS, Ponsi G, Monachesi B, Lorenzini L, Panasiti V, Aglioti SM. Cognitive load and emotional processing in psoriasis: a thermal imaging study. Experimental Brain Research. 2019;237:211-22.
  • 27. Piaserico S, Marinello E, Dessi A, Linder MD, Coccarielli D, Peserico A. Efficacy of Biofeedback and Cognitive-behavioural Therapy in Psoriatic PatientsA Single-blind, Randomized and Controlled Study with Added Narrow-band Ultraviolet B Therapy. Acta Derm Venereol. 2016;96(217):91-5.
  • 28. van Beugen S, Ferwerda M, Spillekom-van Koulil S, Smit JV, Zeeuwen-Franssen ME, Kroft EB, de Jong EM, Otero ME, Donders AR, van de Kerkhof PC, van Middendorp H, Evers AW. Tailored Therapist-Guided Internet-Based Cognitive Behavioral Treatment for Psoriasis: A Randomized Controlled Trial. Psychother Psychosom. 2016;85(5):297-307.
  • 29. Melynyte S, Wang GY, Griskova-Bulanova I. Gender effect on auditory P300: A systematic review. International Journal of Psychophsiology. 2018;133:55-65.
  • 30. Leah H. Rubin L, Neigh GN, Sundermann EE, Xu Y, Scully EP, Maki PM. Sex Differences in Neurocognitive Function in Adults with HIV: Patterns, Predictors, and Mechanisms. Current Psychiatry Reports. 2019;21:94.
  • 31. Hillerer KM, Slattery DA, Pletzer B. Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus. Frontiers in Neuroendocrinology. 2019:100796.
  • 32. Au A, Feher A, McPhee L, Jessa A, Oh S, Einstein G. Estrogens, inflammation and cognition. Front Neuroendocrinol. 2016;40:87-100.
  • 33. Zhu TH, Nakamura M, Farahnik B, Abrouk M, Lee K, Singh R, Gevorgyan A, Koo J, Bhutani T. The Role of the Nervous System in the Pathophysiology of Psoriasis: A Review of Cases of Psoriasis Remission or Improvement Following Denervation Injury. Am J Clin Dermatol. 2016;17(3):257-63.
  • 34. Joachim RA, Kuhlmei A, Dinh QT. Neuronal plasticity of the “brain-skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nevre growth factor-dependent pathways. J Mol Med 2004;85:1369-78.
  • 35. Schmid-Ott G, Jaeger B, Meyer S, et al. Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls. J Allergy Clin Immunol. 2001;108:455-62.
  • 36. Evers AW, Verhoeven EW, Kraaimaat FW, et al. How stres gets under the skin: cortisol and stress reactivity in psoriasis. Br J Dermatol. 2010;163:986-91.
  • 37. Al Abadie MS, Kent GG, Gawkrodger DJ. The relationship between stress and the onset and exacerbation of psoriasis and other skin conditions. Br J Dermatol. 1994;130:199-203.
  • 38. Fordham B, Griffith C, Bundy C. Can stress reduction interventions improve psoriasis? A review. Psychol Health Med. 2013;18:501-14.
  • 39. Jung YH, Shin NY, Jang JH, Lee WJ, Lee D, Choi Y, Choi SH, Kang DH. Relationships among stress, emotional intelligence, cognitive intelligence, and cytokines. Medicine (Baltimore). 2019; 98(18): e15345.

Psoriasis Vulgaris Hastalarında Subklinik Nörolojik Tutulumun İncelenmesi

Yıl 2024, Cilt: 46 Sayı: 3, 169 - 177, 30.09.2024

Sibel Berksoy Hayta , Burhanettin Çiğdem , Rukiye Guner , Şeyda Figül Gökçe , Melih Akyol

https://doi.org/10.7197/cmj.1424299

Öz

ÖZET
Amaç: Bu çalışmanın amacı, psoriasis hastalarında subklinik nörolojik tutulum açısından bilişsel fonksiyonları P300 yöntemi ile değerlendirmek ve hastalık süresi ve şiddeti arasındaki ilişkiyi ortaya koymaktır.
Yöntem: Çalışmaya 40 psoriasis vulgaris hastası ve 40 sağlıklı birey dahil edilmiştir. Her iki gruba standart mini mental test ve Beck Depresyon Envanteri uygulanmıştır. Psoriasis hastalarının PAŞİ (Psoriasis Alan ve Şiddet İndeksi) ve DYKİ (Dermatoloji Yaşam Kalitesi İndeksi) değerleri hesaplanmıştır. Her iki grubun P300 ölçümleri kaydedilmiş ve bilişsel fonksiyonları değerlendirmek amacıyla analiz edilmiştir.
Bulgular: Sağlıklı ve psoriasis grupları arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.681, p=0.301, p=0.138, p=0.739). PAŞİ değerleri açısından karşılaştırıldığında, hasta grubunda PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.211, p=0.422, p=0.106, p=0.305). Hastalık süresine göre değerlendirildiğinde, gruplar arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.901, p=0.244, p=0.632, p=0.868).
Sonuç: Psoriasis hastalarında bilişsel fonksiyonlar, hastalığın varlığı, şiddeti ve süresi ile etkilenmemektedir. Bildiğimiz kadarıyla, mevcut çalışma psoriasis hastalarında bilişsel fonksiyonları değerlendirmede elektrofizyolojik P300 yöntemini kullanan ilk çalışmadır.

Anahtar Kelimeler

Psoriasis biliş P300 nörofizyolojik test bilişsel disfonksiyon

Proje Numarası

T764.

Kaynakça

  • 1. Akyol M, Alper S, Atakan N, Bülbül Başkan E, Gürer MA, Koç E, Onsun N, Ozarmagan G, Şentürk N, Yaylı S. Turkey Psoriasis Treatment Guide-2016. Türkderm- Arch Turk Dermatol Venerology. 2016;50(1):1-56.
  • 2. Bu J, Ding R, Zhou L, Chen X, Shen E. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front. Immunol. 2022;13: 880201.
  • 3. Amanat M, Salehi M, Rezaei N. Neurological and psychiatric disorders in psoriasis. Rev Neurosci. 2018; 29(7):805-13.
  • 4. Biçici F, Berksoy Hayta S, Akyol M, Özçelik S, Ziynet Çınar Z. Evaluation of sleep quality in patients with psoriasis. Türkderm- Arch Turk Dermatol Venerology. 2015; 49: 208-12.
  • 5. Berksoy Hayta S, Güner R, Akyol M, Albayrak F, Kuğu N, Özçelik S. Increased expressed emotion in patients with psoriasis. Neuropsychiatria and Neuropsychologia. 2018: 13(1);9-16.
  • 6. Bettcher BM, Kramer JH. Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini-Review. Clin Pharmacol Ther. 2014; 96(4): 464-9.
  • 7. Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann. N. Y. Acad. Sci. 2000; 908:244-54.
  • 8. Eikelenboom P, Hoozemans JJ, Veerhuis R, van Exel E, Rozemuller AJ, van Gool WA. Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer’s disease. Alzheimers Res Ther. 2012;4:15.
  • 9. Kravitz BA, Corrada MM, Kawas CH. Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Alzheimers Dement. 2009;5:318-23.
  • 10. Bettcher BM, Wilheim R, Rigby T, Green R, Miller JW, Racine CA, Yaffe K, Miller BL, Kramer JH. C-reactive protein is related to memory and medial temporal brain volume in older adults. Brain Behav Immun. 2012;26:103-8.
  • 11. Çölgeçen E, Çelikbilek A, Taslak Keskin D. Cognitive Impairment in Patients with Psoriasis: A Cross-Sectional Study Using the Montreal Cognitive Assessment. Am J Clin Dermatol. 2016;17:413-9.
  • 12. Pezzolo E, Mutlu U, Vernooij MW, Dowlatshahi EA, Gisondi P, Girolomoni G, Tamar Nijsten T, Ikram A, Wakkee M. Psoriasis is not associated with cognition, brain imaging markers and risk of dementia: the Rotterdam Study. 10.1016/j.jaad.2018.07.046
  • 13. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, Culliford D, Perry VH. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 2009;73(10):768-74.
  • 14. Gisondi P, Sala F, Alessandrini F, Avesani V, Zoccatelli G, Beltramello A, Moretto G, Gambina G, Girolomoni G. Mild cognitive impairment in patients with moderate to severe chronic plaque psoriasis. Dermatology.2014;228(1):78-85.
  • 15. Marek-Jozefowicz L, Jaracz M, Placek W, Czajkowski R, Borkowska A. Cognitive impairment in patients with severe psoriasis. Adv Dermatol Allergol. 2017;34(2):120-5.
  • 16. Langley RG, Ellis CN. Evaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment and Lattice System Physicans Global Assessment. J Am Acad Dermatol. 2004;51:563-9.
  • 17. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Reliability and Validity of The Standardized Mini Mental State Examination in The Diagnosis of Mild Dementia in Turkish Population. Türk Psikiyatri Dergisi. 2002; 13(4):273-81.
  • 18. Hisli N. Validity and reliability of Beck depression inventory for university students. Back depresyon envanterinin üniversite öğrencileri için geçerliği, güvenirliği.Turkish Journal of Psychology . 1989;7:3-13.
  • 19. Öztürkcan S, Ermertcan A, Eser E, Şahin MT. Cross validation of Turkish version of Dermatology Life Quality Index (DLQI). International Journal of Dermatology. 2006;45(11):1300-7.
  • 20. Gökçay F, Celebisoy N, Kisabay A, Kumral E, Akyürekli O. P300 and neuropsychological evaluation in Behçet’s disease with and without neurological manifestations. J Neurol. 2004;251 :676-9.
  • 21. Keçeci H, Akyol M. P300 in Behcet's Patients without Neurological Manifestations. The Canadian journal of neurological sciences. 2001; 28(1):66-9.
  • 22. Melynyte S, Wang GY, Griskova-Bulanova I. Gender effect on auditory P300: A systematic review. International Journal of Psychophsiology. 2018;133:55-65.
  • 23. Imamoglu B, Berksoy Hayta S, Guner R, Akyol M, Ozcelik S. Metabolic syndrome may be an important comorbidity in patients with seborrheic dermatitis. Arch Med Sci Atheroscler Dis. 2016;1(1):e158–e161.
  • 24. Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB, Gelfand JM. Prevalence of cardiovascular risk factors in patients with psoriasis. J Am Acad Dermatol 2006; 55: 829-35.
  • 25. Innamorati M, Quinto RM, Lester D, Iani L, Graceffa D, Bonifati C. Cognitive impairment in patients with psoriasis: A matched case-control study. J Psychosom Res. 2018;105:99-105.
  • 26. Panasiti MS, Ponsi G, Monachesi B, Lorenzini L, Panasiti V, Aglioti SM. Cognitive load and emotional processing in psoriasis: a thermal imaging study. Experimental Brain Research. 2019;237:211-22.
  • 27. Piaserico S, Marinello E, Dessi A, Linder MD, Coccarielli D, Peserico A. Efficacy of Biofeedback and Cognitive-behavioural Therapy in Psoriatic PatientsA Single-blind, Randomized and Controlled Study with Added Narrow-band Ultraviolet B Therapy. Acta Derm Venereol. 2016;96(217):91-5.
  • 28. van Beugen S, Ferwerda M, Spillekom-van Koulil S, Smit JV, Zeeuwen-Franssen ME, Kroft EB, de Jong EM, Otero ME, Donders AR, van de Kerkhof PC, van Middendorp H, Evers AW. Tailored Therapist-Guided Internet-Based Cognitive Behavioral Treatment for Psoriasis: A Randomized Controlled Trial. Psychother Psychosom. 2016;85(5):297-307.
  • 29. Melynyte S, Wang GY, Griskova-Bulanova I. Gender effect on auditory P300: A systematic review. International Journal of Psychophsiology. 2018;133:55-65.
  • 30. Leah H. Rubin L, Neigh GN, Sundermann EE, Xu Y, Scully EP, Maki PM. Sex Differences in Neurocognitive Function in Adults with HIV: Patterns, Predictors, and Mechanisms. Current Psychiatry Reports. 2019;21:94.
  • 31. Hillerer KM, Slattery DA, Pletzer B. Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus. Frontiers in Neuroendocrinology. 2019:100796.
  • 32. Au A, Feher A, McPhee L, Jessa A, Oh S, Einstein G. Estrogens, inflammation and cognition. Front Neuroendocrinol. 2016;40:87-100.
  • 33. Zhu TH, Nakamura M, Farahnik B, Abrouk M, Lee K, Singh R, Gevorgyan A, Koo J, Bhutani T. The Role of the Nervous System in the Pathophysiology of Psoriasis: A Review of Cases of Psoriasis Remission or Improvement Following Denervation Injury. Am J Clin Dermatol. 2016;17(3):257-63.
  • 34. Joachim RA, Kuhlmei A, Dinh QT. Neuronal plasticity of the “brain-skin connection”: stress-triggered up-regulation of neuropeptides in dorsal root ganglia and skin via nevre growth factor-dependent pathways. J Mol Med 2004;85:1369-78.
  • 35. Schmid-Ott G, Jaeger B, Meyer S, et al. Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison with healthy controls. J Allergy Clin Immunol. 2001;108:455-62.
  • 36. Evers AW, Verhoeven EW, Kraaimaat FW, et al. How stres gets under the skin: cortisol and stress reactivity in psoriasis. Br J Dermatol. 2010;163:986-91.
  • 37. Al Abadie MS, Kent GG, Gawkrodger DJ. The relationship between stress and the onset and exacerbation of psoriasis and other skin conditions. Br J Dermatol. 1994;130:199-203.
  • 38. Fordham B, Griffith C, Bundy C. Can stress reduction interventions improve psoriasis? A review. Psychol Health Med. 2013;18:501-14.
  • 39. Jung YH, Shin NY, Jang JH, Lee WJ, Lee D, Choi Y, Choi SH, Kang DH. Relationships among stress, emotional intelligence, cognitive intelligence, and cytokines. Medicine (Baltimore). 2019; 98(18): e15345.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Sistemleri
Bölüm Araştırma Makalesi
Yazarlar

Sibel Berksoy Hayta 0000-0002-6185-6094

Burhanettin Çiğdem 0000-0003-4941-9497

Rukiye Guner 0000-0002-5154-4652

Şeyda Figül Gökçe 0000-0002-2719-0428

Melih Akyol 0000-0001-7912-0651

Proje Numarası T764.
Yayımlanma Tarihi 30 Eylül 2024
Gönderilme Tarihi 23 Ocak 2024
Kabul Tarihi 8 Ağustos 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 46 Sayı: 3

Kaynak Göster

AMA Berksoy Hayta S, Çiğdem B, Guner R, Gökçe ŞF, Akyol M. Examination of Subclinical Neurological Involvement in Patients with Psoriasis Vulgaris. CMJ. Eylül 2024;46(3):169-177. doi:10.7197/cmj.1424299
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