EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS

Arzuhan Çetindağ Çiltaş; Ayşegül Öztürk

doi:10.7197/cmj.1153681

EN

EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS

Öz

Absract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats. Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit. Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05). Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Arzuhan Çetindağ Çiltaş ^*
0000-0002-5420-3546
Türkiye

Ayşegül Öztürk
0000-0001-8130-7968
Türkiye

Yayımlanma Tarihi

31 Mart 2023

Gönderilme Tarihi

3 Ağustos 2022

Kabul Tarihi

26 Mart 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 45 Sayı: 1

DOI

https://doi.org/10.7197/cmj.1153681

IZ

https://izlik.org/JA77GY32HF

Kaynak Göster

RIS / Bibtex

APA

Çetindağ Çiltaş, A., & Öztürk, A. (2023). EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. Cumhuriyet Medical Journal, 45(1), 25-34. https://doi.org/10.7197/cmj.1153681

AMA

1.Çetindağ Çiltaş A, Öztürk A. EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. CMJ. 2023;45(1):25-34. doi:10.7197/cmj.1153681

Chicago

Çetindağ Çiltaş, Arzuhan, ve Ayşegül Öztürk. 2023. “EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS”. Cumhuriyet Medical Journal 45 (1): 25-34. https://doi.org/10.7197/cmj.1153681.

EndNote

Çetindağ Çiltaş A, Öztürk A (01 Mart 2023) EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. Cumhuriyet Medical Journal 45 1 25–34.

IEEE

[1]A. Çetindağ Çiltaş ve A. Öztürk, “EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS”, CMJ, c. 45, sy 1, ss. 25–34, Mar. 2023, doi: 10.7197/cmj.1153681.

ISNAD

Çetindağ Çiltaş, Arzuhan - Öztürk, Ayşegül. “EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS”. Cumhuriyet Medical Journal 45/1 (01 Mart 2023): 25-34. https://doi.org/10.7197/cmj.1153681.

JAMA

1.Çetindağ Çiltaş A, Öztürk A. EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. CMJ. 2023;45:25–34.

MLA

Çetindağ Çiltaş, Arzuhan, ve Ayşegül Öztürk. “EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS”. Cumhuriyet Medical Journal, c. 45, sy 1, Mart 2023, ss. 25-34, doi:10.7197/cmj.1153681.

Vancouver

1.Arzuhan Çetindağ Çiltaş, Ayşegül Öztürk. EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS. CMJ. 01 Mart 2023;45(1):25-34. doi:10.7197/cmj.1153681

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Cumhuriyet Science Journal

https://doi.org/10.17776/csj.1602644