Examination of Subclinical Neurological Involvement in Patients with Psoriasis Vulgaris

Sibel Berksoy Hayta; Burhanettin Çiğdem; Rukiye Guner; Şeyda Figül Gökçe; Melih Akyol

doi:10.7197/cmj.1424299

EN TR

Examination of Subclinical Neurological Involvement in Patients with Psoriasis Vulgaris

Abstract

Background : The aim of this study is to evaluate cognitive functions of patients with psoriasis in terms of subclinical neurological involvement using p300 method, and to reveal the correlation between the disease duration and severity if any. Methods: 40 patients with psoriasis vulgaris and 40 healthy individuals were included in the study. Standard mini mental test and beck depression inventory were applied to the groups. PASI values and DLQI values of psoriasis patients were calculated. P300 measurements of both groups were recorded and assessed in order to evaluate the cognitive functions. Results: There was no statistically significant difference between the healthy and psoriasis groups in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.681, p=0.301, p=0.138, p=0.739, respectively). When it was compared in terms of PASI values, there was no statistically significant difference in the patient group in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.211, p=0.422, p=0.106, p=0.305, respectively). When evaluated according to disease duration, there was no statistically significant difference between the groups in terms of PzLat, PzAmp, CzLat and CzAmp values (p=0.901, p=0.244, p=0.632, p=0.868, respectively). Conclusion: Cognitive functions in psoriasis patients are not affected by the presence, severity and duration of the disease. As far as we know, the present study is the first study using electrophysiological P300 method in evaluating the cognitive functions in patients with psoriasis.

Keywords

Psoriasis Vulgaris Hastalarında Subklinik Nörolojik Tutulumun İncelenmesi

Öz

ÖZET Amaç: Bu çalışmanın amacı, psoriasis hastalarında subklinik nörolojik tutulum açısından bilişsel fonksiyonları P300 yöntemi ile değerlendirmek ve hastalık süresi ve şiddeti arasındaki ilişkiyi ortaya koymaktır. Yöntem: Çalışmaya 40 psoriasis vulgaris hastası ve 40 sağlıklı birey dahil edilmiştir. Her iki gruba standart mini mental test ve Beck Depresyon Envanteri uygulanmıştır. Psoriasis hastalarının PAŞİ (Psoriasis Alan ve Şiddet İndeksi) ve DYKİ (Dermatoloji Yaşam Kalitesi İndeksi) değerleri hesaplanmıştır. Her iki grubun P300 ölçümleri kaydedilmiş ve bilişsel fonksiyonları değerlendirmek amacıyla analiz edilmiştir. Bulgular: Sağlıklı ve psoriasis grupları arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.681, p=0.301, p=0.138, p=0.739). PAŞİ değerleri açısından karşılaştırıldığında, hasta grubunda PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.211, p=0.422, p=0.106, p=0.305). Hastalık süresine göre değerlendirildiğinde, gruplar arasında PzLat, PzAmp, CzLat ve CzAmp değerleri açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (sırasıyla p=0.901, p=0.244, p=0.632, p=0.868). Sonuç: Psoriasis hastalarında bilişsel fonksiyonlar, hastalığın varlığı, şiddeti ve süresi ile etkilenmemektedir. Bildiğimiz kadarıyla, mevcut çalışma psoriasis hastalarında bilişsel fonksiyonları değerlendirmede elektrofizyolojik P300 yöntemini kullanan ilk çalışmadır.

Anahtar Kelimeler

Destekleyen Kurum

CUBAP

Proje Numarası

T764.

Etik Beyan

Cumhuriyet University Clinical Research Ethics Committee (2017-01/24).

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Sistemleri

Bölüm

Araştırma Makalesi

Yazarlar

Sibel Berksoy Hayta
0000-0002-6185-6094
Türkiye

Burhanettin Çiğdem
0000-0003-4941-9497
Türkiye

Rukiye Guner ^*
0000-0002-5154-4652
Türkiye

Şeyda Figül Gökçe
0000-0002-2719-0428
Türkiye

Melih Akyol
0000-0001-7912-0651
Türkiye

Yayımlanma Tarihi

30 Eylül 2024

Gönderilme Tarihi

23 Ocak 2024

Kabul Tarihi

8 Ağustos 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 46 Sayı: 3

DOI

https://doi.org/10.7197/cmj.1424299

IZ

https://izlik.org/JA59ZM43CH

Kaynak Göster

RIS / Bibtex

AMA

1.Berksoy Hayta S, Çiğdem B, Guner R, Gökçe ŞF, Akyol M. Examination of Subclinical Neurological Involvement in Patients with Psoriasis Vulgaris. CMJ. 2024;46(3):169-177. doi:10.7197/cmj.1424299