Araştırma Makalesi

Comparison of Dosimetry Results Before 90Y Microembolization Treatment with 99mTc MAA and After 90Y PET/CT Treatment

Cilt: 46 Sayı: 2 29 Haziran 2024
Cumhuriyet Tıp Dergisi Kapak
Cumhuriyet Tıp Dergisi
PDF İndir
TR EN

Comparison of Dosimetry Results Before 90Y Microembolization Treatment with 99mTc MAA and After 90Y PET/CT Treatment

Abstract

Radioembolization with Yttrium-90 (90Y) microspheres stands as an effective treatment option for liver tumors. The suitability of a patient for this treatment is routinely determined through dosimetry based on Technetium-99m Macro Aggregated Albumin (99mTc MAA) SPECT/CT images. This study aims to compare pre-treatment (pre) dosimetry results with 99mTc MAA and post-treatment (post) dosimetry results after 90Y microsphere therapy in patients seeking liver tumor treatment. Eleven patients undergoing liver tumor treatment were randomly included in the study. In 99mTc-MAA dosimetry, the calculated treatment activity was 1.3-6.2 GBq (mean 3.2±1.4), tumor dose was 125.1-527.5 Gy (mean 264.7±139.4), and liver dose was 19.4-38.8 Gy (mean 31.9±5.8). Post-dosimetry using PET/CT images after 90Y microsphere therapy revealed a tumor dose of 156.2-480.4 Gy (mean 266.5±102.9) and a liver dose of 20.6-37.4 Gy (mean 29.1±5.2). The doses exhibited good conformity for both tumor and normal liver tissue (p=0.85716 and p=0.53526, respectively). In conclusion, PET/CT-based post-dosimetry with 90Y microspheres proved to be an effective method in determining liver parenchymal tissue and tumor doses.

Keywords

Etik Beyan

The study was approved by the Local Ethics Committee of Cerrahpasa Faculty of Medicine/Istanbul University-Cerrahpasa in accordance with the Helsinki Declaration (Approval No: 83045809-604.01.02-). Informed consent was obtained from all participating patients.

Kaynakça

  1. Vente MA, Hobbelink MG, van Het Schip AD, Zonnenberg BA, Nijsen JF. Radionuclide liver cancer therapies: from concept to current clinical status. Anticancer Agents Med Chem. 2007;7(4):441-59. DOI: 10.2174/187152007781058569
  2. Bozkurt M. F. Personalized Treatment and Protection from Side Effects. Nuclear Medicine Seminars 2019;5(2),:122-31.
  3. Villalobos A, Soliman MM, Majdalany BS, et al. Yttrium-90 radioembolization dosimetry: what trainees need to know. In Seminars in Interventional Radiology 2020, 37(05): 543-54. DOI: 10.1055/s-0040-1720954
  4. Tong A K, Kao Y H, Too CW, Chin K F, Ng DC, Chow P K. Yttrium-90 hepatic radioembolization: clinical review and current techniques in interventional radiology and personalized dosimetry. The British Journal of Radiology 2016;89(1062), 20150943.
  5. Tafti BA, Padia SA. Dosimetry of Y-90 Microspheres Utilizing Tc-99m SPECT and Y-90 PET. Semin Nucl Med. 2019;49(3):211-17.
  6. Richetta E, Pasquino M, Poli M, et al. PET-CT post therapy dosimetry in radioembolization with resin 90Y microspheres: comparison with pre-treatment SPECT-CT 99mTc-MAA results. Physica Medica 2019;64:16-23.DOI: 10.1016/j.ejmp.2019.05.025
  7. Türkmen C, Demirci E, Selçuk NA, et al. Karaciğer Tümörlerinde Y-90 Radyomikroküre Tedavisi Uygulama Kılavuzu. Nucl Med Semin. 2020;6:416-22. DOI:10.4274/nts.galenos.2020.0034
  8. Selcuk NA, Toklu T, Karaaslan SI. Radionuclide Treatment and Dosimetric Approaches. In Nuclear Medicine Seminars 2015;1(3):158-71.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Fiziği

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

29 Haziran 2024

Gönderilme Tarihi

6 Şubat 2024

Kabul Tarihi

2 Nisan 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 46 Sayı: 2

DOI

https://doi.org/10.7197/cmj.1432517

IZ

https://izlik.org/JA79BU32EC

Kaynak Göster

RIS / Bibtex
AMA
1.Taşlıyurt Ö, Yeyin N, Demir M. Comparison of Dosimetry Results Before 90Y Microembolization Treatment with 99mTc MAA and After 90Y PET/CT Treatment. CMJ. 2024;46(2):104-109. doi:10.7197/cmj.1432517