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False Positive Hepatitis A IgM in Membranous Nephropathy: A Treatment Dilemma

Cilt: 47 Sayı: 2 21 Haziran 2025
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False Positive Hepatitis A IgM in Membranous Nephropathy: A Treatment Dilemma

Abstract

Membranous nephropathy (MN) is a primary cause of nephrotic syndrome in adults, often linked to antibodies against M-type phospholipase A2 receptor (PLA2R). Immunosuppressive therapy, such as rituximab and calcineurin inhibitors, is utilized for high-risk patients. This case report discusses a 74-year-old female with anti-PLA2R-positive MN, whose treatment was delayed due to a false-positive hepatitis A virus (HAV)-IgM result. Despite asymptomatic presentation and normal liver function, concerns about potential viral reactivation complicated clinical decisions. After a month of monitoring, immunosuppressive treatment was initiated, and the patient’s proteinuria achieved remission. This case underscores the importance of thorough evaluation of serological results, especially in cases where viral markers could influence critical treatment decisions. The risk of delaying MN treatment must be balanced against the potential dangers of initiating therapy under uncertain viral infection status.

Keywords

Destekleyen Kurum

Funding: The authors received no specific funding for this work. Conflict of interest: The authors declare that they have no conflict of interest. Availability of data and material: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Etik Beyan

Ethical approval: In this case report, ethical committee approval was not required; therefore, it was not obtained.

Kaynakça

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  5. 5. van de Logt, A. E. et al. Immunological remission in PLA2R-antibody-associated membranous nephropathy: cyclophosphamide versus rituximab. Kidney Int. 93, 1016– 1017 (2018).
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  7. 7. Bower WA , Nainan OV , Han X , Margolis HS . Duration of viremia in hepatitis A virus infection. J Infect Dis. 2000 Jul;182(1):12–7.
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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Hizmetleri ve Sistemleri (Diğer)

Bölüm

Olgu Sunumu

Yazarlar

Yayımlanma Tarihi

21 Haziran 2025

Gönderilme Tarihi

21 Mart 2025

Kabul Tarihi

16 Mayıs 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 47 Sayı: 2

DOI

https://doi.org/10.7197/cmj.1662807

IZ

https://izlik.org/JA37SK87SJ

Kaynak Göster

RIS / Bibtex
AMA
1.Cetin TE, Karataş A, Telli Dizman G, Akçay ÖF, Helvacı Ö. False Positive Hepatitis A IgM in Membranous Nephropathy: A Treatment Dilemma. CMJ. 2025;47(2):45-47. doi:10.7197/cmj.1662807