CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment

Eda Erdiş; Mukaddes Yılmaz; Mahmut Uçar; Hatice Öz; Birsen Yücel

doi:10.7197/cmj.1706597

EN TR

CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment

Öz

Introduction: This study aimed to evaluate overall survival (OS) and disease-free survival (DFS) in patients with muscle-invasive bladder cancer (MIBC) who refused radical cystectomy and were not eligible for bladder-preserving treatment, and to identify prognostic factors affecting these outcomes under chemoradiotherapy (CRT). Materials and Methods: A total of 71 patients with non-metastatic MIBC who underwent definitive CRT between 2010 and 2024 were retrospectively analyzed. Clinical findings and survival outcomes following CRT were evaluated. Results: Among the 71 patients with bladder cancer, 90% were male and 10% were female. The median age was 72 years. Local recurrence occurred in 23 patients (32%), and distant metastasis was observed in 52 patients (73%). Male gender, concurrent chemotherapy including a platinum-based regimen, and a radiotherapy dose ≥60 Gy were identified as independent favorable prognostic factors for both OS and DFS. In addition, performance status was found to be an independent prognostic factor affecting OS. Conclusion: Definitive chemoradiotherapy appears to be a reasonable treatment option for appropriately selected patients with muscle-invasive bladder cancer, particularly in those who decline radical cystectomy or are ineligible for trimodal bladder-preserving therapy.

Anahtar Kelimeler

Radikal Sistektomiyi kabul etmeyen mesane koruyucu tedaviye de uygun olmayan hastaların KRT sonuçları

Öz

Giriş: Bu çalışmada kas invaziv mesane kanserinde radikal sistektomiyi kabul etmeyen hastalarda koruyucu tedavi de uygun olmayan hastalarin kemoradyoterapi (KRT) ile genel sağkalımı (OS) ve disease free survival (DFS) etkileyen prognostik faktörlerin araştırılması amaçlandı. Gereç ve Yöntem: Çalışmaya, 2010-2024 yılları arasında metastatik olmayan kas invaziv mesane kanseri olan 71 hasta dahil edildi. Klinik bulgular ve KRT sonrası sağkalım analizi değerlendirildi. Bulgular: Mesane kanserli 71 hastanın verileri incelendiğinde hastaların %90’ının erkek, %10’unun kadın olduğu saptanmıştır. Hastaların medyan yaşı 72 idi. 23 (%32) hastada lokal nüks ve 52 (%73) hastada uzak metastaz gelişmiştir. Erkek cinsiyet, eşzamanlı kemoterapi rejiminde platin kullanımı, RT dozunun ≥60 Gy olması hem OS’yi hemde DFS’yi etkileyen bağımsız iyi prognostik faktör olarak bulunmuştur. Ayrıca performans durumu da OS’yi etkileyen bağımsız iyi prognostik faktör olarak tespit edilmiştir. Sonuç: Kas invaziv mesane kanseri özellikle radikal sistektomiyi reddeden ya da mesane koruyucu trimodal tedaviye uygun olmayan hastalarda uygulanan definitif kemoradyoterapi uygun hastalarda makul bir seçenektir.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Multimorbidite, Uygulama Bilimi ve Değerlendirme

Bölüm

Araştırma Makalesi

Yazarlar

Eda Erdiş ^*
0000-0003-3003-8643
Türkiye

Mukaddes Yılmaz
0000-0002-7927-8480
Türkiye

Mahmut Uçar
0000-0002-3311-6152
Türkiye

Hatice Öz
0009-0008-4919-8536
Türkiye

Birsen Yücel
0000-0002-0083-6866
Türkiye

Yayımlanma Tarihi

21 Haziran 2025

Gönderilme Tarihi

27 Mayıs 2025

Kabul Tarihi

11 Haziran 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 47 Sayı: 2

DOI

https://doi.org/10.7197/cmj.1706597

IZ

https://izlik.org/JA42SY96CE

Kaynak Göster

RIS / Bibtex

APA

Erdiş, E., Yılmaz, M., Uçar, M., Öz, H., & Yücel, B. (2025). CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment. Cumhuriyet Medical Journal, 47(2), 28-34. https://doi.org/10.7197/cmj.1706597

AMA

1.Erdiş E, Yılmaz M, Uçar M, Öz H, Yücel B. CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment. CMJ. 2025;47(2):28-34. doi:10.7197/cmj.1706597

Chicago

Erdiş, Eda, Mukaddes Yılmaz, Mahmut Uçar, Hatice Öz, ve Birsen Yücel. 2025. “CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment”. Cumhuriyet Medical Journal 47 (2): 28-34. https://doi.org/10.7197/cmj.1706597.

EndNote

Erdiş E, Yılmaz M, Uçar M, Öz H, Yücel B (01 Haziran 2025) CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment. Cumhuriyet Medical Journal 47 2 28–34.

IEEE

[1]E. Erdiş, M. Yılmaz, M. Uçar, H. Öz, ve B. Yücel, “CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment”, CMJ, c. 47, sy 2, ss. 28–34, Haz. 2025, doi: 10.7197/cmj.1706597.

ISNAD

Erdiş, Eda - Yılmaz, Mukaddes - Uçar, Mahmut - Öz, Hatice - Yücel, Birsen. “CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment”. Cumhuriyet Medical Journal 47/2 (01 Haziran 2025): 28-34. https://doi.org/10.7197/cmj.1706597.

JAMA

1.Erdiş E, Yılmaz M, Uçar M, Öz H, Yücel B. CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment. CMJ. 2025;47:28–34.

MLA

Erdiş, Eda, vd. “CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment”. Cumhuriyet Medical Journal, c. 47, sy 2, Haziran 2025, ss. 28-34, doi:10.7197/cmj.1706597.

Vancouver

1.Eda Erdiş, Mukaddes Yılmaz, Mahmut Uçar, Hatice Öz, Birsen Yücel. CRT results: patients who do not accept radical cystectomy but they are not suitable for bladder-preserving treatment. CMJ. 01 Haziran 2025;47(2):28-34. doi:10.7197/cmj.1706597