Evaluation of the efficacy of intra-articular tranexamic acid in patients with hypertension undergoing simultaneous bilateral total knee arthroplasty

Adem Çöbden; İsmet Yalkın Çamurcu; Hanifi Üçpunar; Hüseyin Demirel; Halil Gök; Mehmet Kış

doi:10.7197/223.vi.378528

EN TR

Evaluation of the efficacy of intra-articular tranexamic acid in patients with hypertension undergoing simultaneous bilateral total knee arthroplasty

Abstract

ABSTRACT

Background: The relationship between hypertension (HT) and increased perioperative transfusion rate in patients who underwent total knee arthroplasty (TKA) was previously investigated in the literature. This phenomenon may also increase the need for blood transfusion in patients who underwent bilateral simultaneous TKA despite using tranexamic acid (TXA). The main purpose of this study was to evaluate the decrease in hemoglobin levels and need for blood transfusion in patients with the diagnosis of HT who underwent bilateral simultaneous TKA after intra-articular (IA) administration of TXA in comparison to those who did not receive TXA.

Methods: One hundred and ninety-one patients with the diagnosis of HT who underwent bilateral simultaneous TKA and fulfilled the criteria, were evaluated in this retrospective study. Patients were grouped as TXA group (individuals who received IA TXA) and control group (did not receive TXA). Primary outcome measures were decrease in hemoglobin levels and number of blood units transfused.

Results: Both groups were similar in age, gender, body mass index and American Society of Anesthesiologist (ASA) score and no statistically significant differences were observed. There was also no statistically significant difference between groups in terms of decrease in hemoglobin levels (P=0.844) and number of blood units transfused (P=0.095).

Conclusion: According to our results, in patients with the diagnosis of HT undergoing simultaneous bilateral TKA procedure, no significant difference was observed in the decrease of hemoglobin level and number of blood units transfused between patients who received IA TXA in comparison to those who did not receive TXA.

Keywords: tranexamic acid; hypertension; total knee arthroplasty; blood loss; blood transfusion; hemoglobin level

Keywords

tranexamic acid; hypertension; total knee arthroplasty; blood loss; blood transfusion; hemoglobin level

Eşzamanlı bilateral total diz artroplastisi uygulanan hipertansiyonlu hastalarda intra-artiküler tranexamik asit etkinliğinin değerlendirilmesi

Öz

ÖZET

Amaç: Total diz artroplastisi (TDA) uygulanan hastalarda hipertansiyon (HT) ile artmış perioperatif transfüzyon oranı arasındaki ilişki literatürde daha önce araştırılmıştır. Bu durum aynı zamanda traneksamik asit (TXA) kullanmasına rağmen eşzamanlı bilateral TKA uygulanan hastalarda kan nakli ihtiyacını da artırabilir. Bu çalışmanın temel amacı, TXA'nın intraartiküler (İA) uygulanmasından sonra eşzamanlı bilateral TDA yapılan HT tanılı hastalarda, TXA almayanlara kıyasla, hemoglobin düzeylerinde azalma ve kan transfüzyonu ihtiyacını değerlendirmektir .

Yöntem: Bu retrospektif çalışmada, eşzamanlı bilateral TDA uygulanan ve kriterlere uyan HT tanılı 191 hasta değerlendirildi. Hastalar TXA grubu (IA TXA alanlar) ve kontrol grubu (TXA almayanlar) olarak gruplandırıldı. Temel sonuç olarak belirleyiciler, hemoglobin düzeyleri ve kan transfüzyonu ünite sayısında azalma idi.

Bulgular: Her iki grup yaş, cinsiyet, vücut kitle indeksi ve Amerikan Anesteziyoloji Derneği (ASA) skoru bakımından benzerdi ve istatistiksel olarak anlamlı bir farklılık gözlenmedi. Hemoglobin düzeylerinde (P = 0.844) azalma ve kan transfüzyonu ünite sayısı (P = 0.095) açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu.

Sonuç: Bulgularımıza göre, eşzamanlı bilateral TKA prosedürü uygulanan HT tanılı hastalarda, IA TXA alan ve almayan hastalar arasında hemoglobin seviyesinin azalması ve kan transfüzyonu ünite sayısı arasında istatistiksel olarak anlamlı fark bulunamamıştır.

Anahtar Kelimeler: traneksamik asit; hipertansiyon; total diz artroplastisi; kan kaybı; kan nakli; hemoglobin seviyesi

Anahtar Kelimeler

traneksamik asit; hipertansiyon; total diz artroplastisi; kan kaybı; kan nakli; hemoglobin seviyesi

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Adem Çöbden ^*
Sivas Numune Hastanesi, Sivas
Türkiye

İsmet Yalkın Çamurcu
ERZİNCAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ORTOPEDİ VE TRAVMATOLOJİ ANABİLİM DALI
Türkiye

Hanifi Üçpunar
ERZİNCAN ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ORTOPEDİ VE TRAVMATOLOJİ ANABİLİM DALI
Türkiye

Hüseyin Demirel
Sivas Numune Hastanesi, Sivas
Türkiye

Halil Gök
Sivas Numune Hastanesi, Sivas
Türkiye

Mehmet Kış
Sivas Numune Hastanesi, Sivas
Türkiye

Yayımlanma Tarihi

5 Haziran 2018

Gönderilme Tarihi

13 Ocak 2018

Kabul Tarihi

6 Nisan 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 40 Sayı: 2

DOI

https://doi.org/10.7197/223.vi.378528

IZ

https://izlik.org/JA88RF62RZ

Kaynak Göster

RIS / Bibtex

AMA

1.Çöbden A, Çamurcu İY, Üçpunar H, Demirel H, Gök H, Kış M. Evaluation of the efficacy of intra-articular tranexamic acid in patients with hypertension undergoing simultaneous bilateral total knee arthroplasty. CMJ. 2018;40(2):150-156. doi:10.7197/223.vi.378528