Obezlerde Ortalama Platelet Hacmi (MPV), Vücut Kitle İndeksi ile Koreledir

Naim Ata

doi:10.7197/223.vi.491832

EN TR

Mean Platelet Volume (MPV) is Correlated with Body Mass Index

Abstract

Objectıves:Obesity is a common health problem all over the world, leading to significant chronic diseases such as diabetes mellitus, hypertension and coronary artery disease. Platelets are one of the blood components that play a role in a number of important pathways such as inflammation and endothelial activation other than hemostasis. They become more metabolically active as their volume increases. In many studies increase in MPV has negative effects on acute coronary syndrome, stent thrombosis and serbrovascular events. In this study, it was aimed to evaluate whether there is a correlation between body mass index (BMI) used in the definition and classification of obesity and mean platelet volume (MPV).

Methods:Seventy-two patients who presented to the internal medicine outpatient clinic due to obesity and had no hypertension, diabetes mellitus and hyperlipidemia were included in the study. After the basal demographic characteristics of the patients were recorded, transthoracic echocardiographic examination was performed to exclude possible cardiac pathologies.Examples of routine biochemistry and blood parameters were obtained and analyzed

Results:The mean age of the patients was 45.06 (± 10.69) years, and the mean BMI was determined as 43.4 kg / m2 (± 5.3).Transthoracic echocardiographic examinations were found within normal limits. The mean platelet volume was 8.57 fL (± 1.22) and there was a positive correlation between BMI and MPV (p: 0.004, r: 0.319).No significant correlation was found with other parameters.

Conclusıons:Increase in body mass index is corroleted with increase in MPV values. MPV increase may play a role in the etiopathogenesis of chronic diseases associated with BMI increase in obesity patients.

Keywords

Obesity. Body mass index

Obezlerde Ortalama Platelet Hacmi (MPV), Vücut Kitle İndeksi ile Koreledir

Öz

Amaç: Obezite, tüm dünyada giderek yaygınlaşan, diabetes mellitus, hipertansiyon ve koroner arter hastalığı gibi önemli kronik hastalıklara yol açan bir sağlık problemidir. Trombositler, hemostaz dışında inflamasyon ve endotel aktivasyonu gibi bir çok önemli yolakta rol oynayan kan bileşenlerinden biridir. Hacimleri artıkça metabolik olarak daha aktif olurlar. Yapılan bir çok çalışmada MPV artışının; akut koroner sendrom, stent trombozu ve serbrovasküler olay seyrinde olumsuz etkilerinin olduğu görülmüştür. Bu çalışmada obezite tanım ve sınıflandırmasında kullanılan vücut kitle İNDEKSİ (VKİ) ve ortalama trombosit hacmi (MPV) arasında korelasyonun olup olmadığının değerlendirilmesi amaçlanmıştır.

Gereç ve yöntemler: Obezite nedeni ile dahiliye polikliniğine başvuran ve hipertansiyon diabetes mellitus ve hiperlipidemi saptanmayan 78 hasta çalışmaya dahil edilmiştir. Hastaların bazal demografik özellikleri kayıt edildikten sonra olası kardiyak patolojileri dışlamak için transtorasik ekokardiyografik inceleme yapılmıştır. Rutin biyokimya ve kan parametleri için örnekler alınıp incelenmiştir

Bulgular:Hastaların ortalama yaşları 45.06 (±10.69) yıl olup, ortalama VKİ 43.4 kg/m²(±5.3) olarak tespit edilmiştir. Transtorasik ekokardiyografik incelemeleri normal sınırlarda tespit edilmiştir. Ortalama trombosit hacimleri 8.57 fL(±1.22) olup VKİ ile MPV arasında pozitif korelasyon saptanmıştır (p:0.004, r:0.319). Diğer parametler ile anlamlı korelasyon tespit edilmememiştir.

Sonuç: Vücut kitle İNDEKSİ artışı MPV değerindeki artış ile koroledir. Obezite hastalarında VKİ artış ile birlkte görülen kronik hastalıkların etyopatogenizde MPV artışı rol oynayabilir.

Anahtar Kelimeler

Obezite,Vücut kitle indeksi

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Naim Ata ^*
Türkiye

Yayımlanma Tarihi

29 Aralık 2018

Gönderilme Tarihi

3 Aralık 2018

Kabul Tarihi

26 Aralık 2018

Yayımlandığı Sayı

Yıl 2018 Cilt: 40 Sayı: 4

DOI

https://doi.org/10.7197/223.vi.491832

IZ

https://izlik.org/JA57YM37PW

Kaynak Göster

RIS / Bibtex

AMA

1.Ata N. Obezlerde Ortalama Platelet Hacmi (MPV), Vücut Kitle İndeksi ile Koreledir. CMJ. 2018;40(4):432-437. doi:10.7197/223.vi.491832