Serum osteopontin values in patients with ischemic stroke
Abstract
Objective: Osteopontin (OPN) is an extracellular matrix protein which has been associated with immune response and tissue repair in the central nervous system.
We set out to investigate the OPN values and its association with clinical features in patients with ischemic stroke.
Method: Serum OPN values of 35 patients with ischemic stroke were compared with 35 controls at the admission and at the seventh day following the event. Correlations between OPN levels and disease specific features were also calculated.
Results: Serum OPN values were not significantly different between patients and controls at baseline. In patients, an increase in OPN values was detected at follow-up which was significantly higher than the controls. The OPN levels were not correlated with infarct size or disease severity.
Conclusions: Serum OPN levels increase not in the hyperacute/acute phase of the stroke but in the subacute phase. No association with disease severity or lesion volume is detected.
Keywords
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
28 Mart 2019
Gönderilme Tarihi
10 Aralık 2018
Kabul Tarihi
26 Mart 2019
Yayımlandığı Sayı
Yıl 2019 Cilt: 41 Sayı: 1