The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters

Nurullah Çelik

doi:10.7197/cmj.vi.551051

EN

The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters

Abstract

Objective: To compare cardiovascular risk factors in obese patients with or without Subclinical Hypothyroidism (SH), also to estimate the prevalence of SH in obese children and adolescents.

Method: A total of 226 obese children and adolescents aged 6-18 years were included in the study. Two groups were created as euthyroid group (n=195) and SH group (n=31). After an 8-12 hour overnight fasting, serum blood glucose, insulin, HDL, LDL, cholesterol, triglyceride TSH, free T4, ALT, AST levels were measured. HOMA-IR and atherogenic index (AI) were calculated.

Results: Prevalence of SH was estimated as 14.1 %. The values of fasting glucose, fasting insülin, ALT, AST, TSH, HOMA-IR levels were significantly higher ın SH group than euthyroid group. There was a positive correlation between TSH and fasting glucose, insülin, triglyceride, ALT, AST, HOMA-IR, AI. It was also demonstrated that the TSH level was significantly and independently related to HOMA-IR value ın multiple regression analysis (p=0.001).

Conclusions: Obese patients with SH may be more susceptible to metabolic complications than euthyroid subjects.

Keywords

Adolescent,obesity,Prevalence,subclinical hypothyroidism

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Nurullah Çelik ^*
0000-0003-1583-6807
Türkiye

Yayımlanma Tarihi

31 Aralık 2019

Gönderilme Tarihi

8 Nisan 2019

Kabul Tarihi

31 Aralık 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 41 Sayı: 4

DOI

https://doi.org/10.7197/cmj.vi.551051

IZ

https://izlik.org/JA88GP23RZ

Kaynak Göster

RIS / Bibtex

AMA

1.Çelik N. The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters. CMJ. 2019;41(4):691-697. doi:10.7197/cmj.vi.551051

Cited By

Predictive markers of metabolically healthy obesity in children and adolescents: can AST/ALT ratio serve as a simple and reliable diagnostic indicator?

European Journal of Pediatrics

https://doi.org/10.1007/s00431-023-05296-3

Öz

The prevalence of subclinical hypothyroidism in obese children and adolescents and its effects on metabolic parameters

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Predictive markers of metabolically healthy obesity in children and adolescents: can AST/ALT ratio serve as a simple and reliable diagnostic indicator?