Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors

Bülent Uygungelen; Serhat İçağasıoğlu; Fettah Acıbucu; Fatih Kılıçlı; Ali Uslu; İbrahim Gül

EN TR

Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors

Abstract

Abstract

Aim. Hypertension is one of the major risk factors for atherosclerosis. Adiponectin is mainly synthesized by white adipose tissue; it is known to have anti-atherogenic and anti-inflammatory effects on endothelial cells and macrophages. Methods. A total of 80 individuals including 48 hypertensive and 32 normotensive individuals were included in the study. Groups were separated as obese and non-obese. Results. It was found out that the patient group had statistically higher systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, triglyceride, low density lipoprotein, high sensitive C reactive protein and microalbuminuria values than the control group while high density lipoprotein values were significantly lower (p<0.05). When adiponectin levels of the groups were compared, the patient group had an adiponectin level of 8.66±2.75 µg/mL and the control group had an adiponectin level of 15.01±3.99 µg/mL. There was a statistically significant difference between two groups (p<0.05). There was a negative correlation between adiponectin level and atherosclerotic risk factors. Conclusion. Adiponectin level was lower in hypertensive group when compared to the control group; there was also a significant association between adiponectin and atherosclerotic risk factors. A low adiponectin level constitutes an important risk for development of atherosclerosis.

Keywords: Atherosclerosis, hypertension, adiponectin

Özet

Amaç. Hipertansiyon aterosklerozun majör risk faktörlerindendir. Adiponektin başlıca beyaz adipoz dokudan sentez edilmekte ve endotelyal hücreler ve makrofajlar üzerinde antiaterojenik ve antiinflamatuar etkileri olduğu bilinmektedir. Yöntem. Çalışmaya 48’i hipertansif 32 tanesi normotansif 80 birey alındı. Gruplar kendi arasında obez ve nonobez olarak ayrıldı. Bulgular. Hasta grubunun kontrol grubuna göre sistolik kanbasıncı, diastolik kanbasıncı, açlık kan şekeri, total kolesterol, trigliserit, low density lipoprotein-C, hs-CRP ve mikroalbuminüri değerleri istatistiksel olarak anlamlı yüksek, high density lipoprotein-C değerleri ise anlamlı düşük bulundu (p<0,05). Grupların adiponektin düzeyleri karşılaştırıldığında; hasta grubunda 8,66±2,75 µg/mL, kontrol grubunda 15,01±3,99 µg/mL olarak bulundu. Aradaki farklılık istatistiksel olarak anlamlı idi (p<0,05). Adiponektin seviyesi ile aterosklerotik risk faktörleri arasında negatif yönlü bir korelasyon bulundu. Sonuç. Sonuç olarak adiponektin düzeyi hipertansif grupta kontrole göre daha düşüktü ve ateroskleroz risk faktörleri ile aralarında anlamlı ilişki vardı. Adiponektin düzeyinin düşük olması ateroskleroz gelişimi için önemli bir risk oluşturmaktadır.

Anahtar sözcükler: Ateroskleroz, hipertansiyon, adiponektin

Keywords

Atherosclerosis, hypertension, adiponectin

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

-

Bölüm

-

Yazarlar

Bülent Uygungelen

Serhat İçağasıoğlu

Fettah Acıbucu

Fatih Kılıçlı

Ali Uslu

İbrahim Gül

Yayımlanma Tarihi

27 Haziran 2013

Gönderilme Tarihi

7 Aralık 2012

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2013 Cilt: 35 Sayı: 2

IZ

https://izlik.org/JA53RA79HT

Kaynak Göster

RIS / Bibtex

AMA

1.Uygungelen B, İçağasıoğlu S, Acıbucu F, Kılıçlı F, Uslu A, Gül İ. Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors. CMJ. 2013;35(2):206-214. https://izlik.org/JA53RA79HT

Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors

Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors

Abstract

Keywords

Original research-Orijinal araştırma

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

Kaynak Göster