Cancer antigen 125 level is determined by tricuspid regurgitation among patients with stable systolic heart failure
Öz
Abstract
Aim. Cancer antigen 125 (CA-125) is a soluble glycoprotein with high molecular weight. Recently, increased serum CA-125 levels were also documented in patients with heart failure (HF). We aimed to show what factors influence serum levels of CA-125 among patients with chronic systolic HF. Methods. Patients, who had chronic systolic HF with echocardiographically determined ejection fraction (EF) <45% were enrolled into final analysis (n=56). CA-125 levels were classified into two as those with normal (<35 U/mL) and high levels (≥35 U/mL). Results. Patients with Right ventricular (RV) dilatation had significantly higher CA-125 levels compared to those without RV dilatation. Besides, patients with RV dilatation had higher systolic pulmonary artery pressure (SPAP) levels compared to those without. Patients with high CA-125 levels had more frequent RV dilatation, higher pulmonary artery pressure, more severe tricuspid regurgitation. Tricuspid regurgitation was the only significant predictor of high CA-125 levels in patients with stable chronic systolic HF. Conclusion. It was shown in this study that tricuspid regurgitation was the only independent predictor of high CA-125 levels among patients with chronic stable systolic HF.
Keywords: CA-125, heart failure, right ventricle, tricuspid regurgitation
Özet
Amaç. Kanser antijen 125 (CA-125) yüksek molekül ağırlıklı çözülebilir bir glikoproteindir. Son yıllarda kalp yetersizliği (KY) hastalarında serum CA-125 düzeylerinin arttığı gösterilmiştir. Bu çalışmada kronik sistolik KY hastalarında serum CA-125 düzeylerini etkileyen faktörleri göstermeyi amaçladık. Yöntem. Sistolik KY ekokardiyografik olarak gösterilmiş, ejeksiyon fraksiyon <%45 olan hastalar son analize dahil edildi (n=56). CA-125 düzeyleri normal (<35 U/mL) ve yüksek (≥35 U/mL) olarak iki gruba ayrıldı. Bulgular. Sağ ventrikül (Sağ V) dilatasyonu olan hastalarda Sağ V dilatasyonu olmayanlara göre CA-125 düzeyleri anlamlı olarak daha yüksekti. Bunun yanında Sağ V dilatasyonu olan hastalarda olmayanlara göre sistolik pulmoner arter basıncı (SPAB) değerleri daha yüksekti. CA-125 düzeyleri yüksek olan hastalarda Sağ V dilatasyonu daha sık, SPAB daha yüksek, triküspit yetmezliği daha ciddiydi. Stabil kronik sistolik KY hastalarında sadece triküspit yetmezliği, yüksek CA-125 düzeyini predikte etmektedir. Sonuç. Bu çalışma göstermektedir ki stabil kronik kalp yetmezliği hastalarında, triküspit yetersizliği, yüksek CA-125 düzeylerinin bağımsız prediktörüdür.
Anahtar sözcükler: CA-125, kalp yetersizliği, sağ ventrikül, triküspit yetmezliğiAnahtar Kelimeler
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
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Bölüm
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Yayımlanma Tarihi
8 Nisan 2014
Gönderilme Tarihi
8 Nisan 2014
Kabul Tarihi
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Yayımlandığı Sayı
Yıl 2014 Cilt: 36 Sayı: 2