Assessment of cardiac functions in thalassemia patients with m-mode echocardiography
Abstract
Objective: Although there is increased survival and quality of life for thalassemia patients, which results from a genetic defect in globin synthesis, heart diseases are still important causes of morbidity and mortality related to the iron burden. Therefore, we aimed to evaluate the cardiac functions of thalassemia patients followed up in Hatay State Hospital using echocardiography.
Method: A total of 101 patients with 7 thalassemia intermedia and 94 thalassemia major who were followed at Hatay state hospital were examined retrospectively. Of patients, 47 were male and 54 were female. Their ages ranged between 1-17 years (mean 8.6±4.6 years). M-mode echocardiography was used to measure LVEDd (left ventricular end-diastolic diameter) and EF (ejection fraction). The demographic and laboratory values of the patients were obtained from their files.
Results: The mean of LVEDd (mm) and EF (%) were evaluated as 34.8±6.1, and 66.36±1.4 with M-mode echocardiography, respectively. When the correlation between age, ferritin and LVEDd and EF were evaluated; it was determined that there was a high positive correlation (r=0.649) between age and LVEDd (p<0.01). A negative correlation was detected between ferritin and EF (r=-0.271) (p<0.01). EF was found to be significantly lower in the group with ferritin <2000. LVEDd was found to be increased in the group with ferritin >2000, although it was not statistically significant.
Conclusions: In our study, it was shown that EF was decreased with increasing ferritin and LVEDS was increased with increasing age of patients with thalassemia. The ideal ferritin level which was ensured after suitable chelation therapy should be an important goal to reduce cardiac involvement.
Keywords
Kaynakça
- 1. Quirolo K, Vichinsky E. Hemoglobinopathies. In: Kliegman RM. Behrman RE, Jenson HB, eds. Nelson Textbook of Pediatrics. 17th ed. WB Saunders Co.Philadelphia;2003: Chap.454.
- 2. Beutler E, Ferlitti V, Ho NJ, et al. Relationship of body iron stores to levels of serum ferritin, serum iron, unsaturated iron binding capacity and transferrin saturation in patients withiron storage disease. Acta Haematol 2002;107:145-9.
- 3. Spirlto P, Maron BJ: Doppler echocardiography for assessing left ventricular diastolic function. Ann Int Med.1988;109:122.
- 4. Vogel M, Anderson LJ, Holden S, et al. Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. Eur Heart J. 2003;24:113-119.
- 5. Spirito P, Lupl G, Melevendi C, Vecchio C: Restrictive diastolic abnormalities identified by Doppler echocarQiography in patients with thalassaemia major. Circulation. 1990;82:88.
- 6. Lewls BS, Lewls N, Dagarı I, Rachmllewitz EA,Gotsman MS, Sapoznikov D: Studies of left ventricular function in anemia due to B-thalassaemia. Isr J Med Sci 18:928, 1982
- 7. Nazan ÖZBARLAS, Arınan BİLGİÇ, Fatma GÜMRÜK, Çiğdem ALTAY. Talasemili Hastalarda Sol Ventrikül Diyastolik Fonksiyonunun Doppler Ekokardiyografi ile Değerlendirilmesi. Türk Kardiyol Dern Arş 1993;21:85-89.
- 8. Mustafa KIR, Nurettin ÜNAL, Gül Sağın SAYLAM, Ulaş KARADAŞ, Murat ŞAHİN. Ventriküler septal defektli çocuklarda sol ventrikül fonksiyonlarının miyokardiyal perfromans indksi (Tei indeksi) kullanılarak değerlendirilmesi. Dokuz Eylül tıpl fakültesi dergisi. 2008;S:113-119.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yazarlar
Gönül Oktay
0000-0002-2996-4722
Andorra
Hasan Demetgül
0000-0001-9608-3127
Yasemin Çoban
0000-0002-5283-239X
Andorra
Gökçen Öz Tunçer
0000-0002-4027-6330
Andorra
Yılmaz Akbaş
0000-0003-3919-4685
Andorra
Tuğçe Tural Kara
0000-0001-5148-2060
Andorra
Yayımlanma Tarihi
31 Aralık 2019
Gönderilme Tarihi
8 Ekim 2019
Kabul Tarihi
31 Aralık 2019
Yayımlandığı Sayı
Yıl 2019 Cilt: 41 Sayı: 4