PD-1 and PD-L2: Do they have prognostic value in lymphomas?
Abstract
Objective: PD-1 (programmed death-1) is an immune checkpoint receptor that modulates T-cell activity in peripheral tissues via interaction with its ligands, PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2). Tumor cells upregulate PD-L1 or PD-L2 to dampen T lymphocyte attack. The checkpoint inhibition by tumor cells via the PD-1 pathway suppress the antitumor immune response. The role of PD-1 pathway has been extensively investigated in non-hematologic malignancies, however, the exact role of this pathway is not established in hematologic disorders. So, we aimed to demostrate the PD-1 and PD-L2 expresion rate of various lymphoma subtypes, and to evaluate whether PD-1 and PD-L2 expresion have impact on prognosis.
Method: For this purpose, pre-treatment lymph node biopsy specimens of 92 patients [25 Hodgkin lymphoma (HL) and 67 non-Hodgkin lymphoma (NHL)] have been stained with monoclonal
antibody immunstains of PD-1 and PD-L2.
Results: The overall expression rate of PD-1 was 76% and 82.1% in patients with HL and NHL, respectively. PD-L2 expression rate was weak in both HL and NHL cases. Since we have evaluated whether there is a correlation between immunohistochemistry (IHC) results and survival of patients with HL and NHL, we couldn’t demonstrate a meaningful evidence that these markers have an impact on prognosis.
Conclusions: We conclude that the role of PD-1 pathway can be demonstrated by IHC. If IHC markers might be standardized in the future, especially a cutoff that defines a clinically significant positive and predictive value, may help identifying patients more likely to benefit from anti-PD-1 therapies.
Keywords
Kaynakça
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Ayrıntılar
Birincil Dil
İngilizce
Konular
Sağlık Kurumları Yönetimi
Bölüm
Araştırma Makalesi
Yazarlar
Serdal Korkmaz
*
0000-0002-5759-2735
Türkiye
Selahattin Erdem
0000-0001-7804-9582
Türkiye
Ebru Akay
0000-0003-1190-1800
Türkiye
Hatice Karaman
0000-0002-5250-5663
Türkiye
Muzaffer Keklik
0000-0002-6426-5249
Türkiye
Yayımlanma Tarihi
1 Temmuz 2021
Gönderilme Tarihi
5 Kasım 2019
Kabul Tarihi
21 Haziran 2021
Yayımlandığı Sayı
Yıl 2021 Cilt: 43 Sayı: 2