Definitive radiotherapy or chemoradiotherapy results and side effects in elderly bladder cancer patients

Birsen Yücel; Eda Erdiş

doi:10.7197/cmj.vi.643500

EN

Definitive radiotherapy or chemoradiotherapy results and side effects in elderly bladder cancer patients

Abstract

Objective: Bladder cancer is most commonly observed in elderly patients. In these patients, it is not always possible to give the necessary treatment for the disease. In this study, definitive radiotherapy (RT) or chemoradiotherapy (CRT) results and side effects, as well as prognostic factors, were investigated in elderly bladder cancer patients.

Method: The results of 36 elderly patients who received definitive RT or CRT for bladder cancer between the years 2010–2018 in Sivas Oncology Center of Cumhuriyet University Medical Faculty were analyzed retrospectively.

Results: The median age of the patients was 75 (range, 65–84). Sixteen patients (44%) underwent RT without chemotherapy and 20 patients (56%) received CRT. Complete response was detected in 19 (53%) patients. The median survival was 18 months (range 3–102 months) and the overall 2-year survival rate was 37%. Treatment response (p < .001) and performance status of the patients (p = .001) were found to be statistically significant prognostic factors in patients' survival. However, sex, comorbidity, Charlson Comorbidity index, risk groups, treatment modality (RT vs. CRT), presence of in situ, grade, status of tumor foci (unifocal vs. multifocal), degree of tumor resection in transurethral resection of the bladder (TUR-B, complete vs. incomplete resection), chemotherapy after CRT, concurrent chemotherapy regimen (ciplatin vs.gemcitabine), RT dose (< 60 Gy vs. ≥60 Gy), and the device used in RT (linac vs. TomoTherapy) were not statistically significant.

Conclusions: Good performance and completed response to treatment in elderly bladder cancer patients positively affects survival.

Keywords

Bladder cancer,elderly patients,radiotherapy,chemoradiotherapy

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Birsen Yücel ^*
Türkiye

Eda Erdiş
0000-0003-3003-8643
Türkiye

Yayımlanma Tarihi

31 Aralık 2019

Gönderilme Tarihi

6 Kasım 2019

Kabul Tarihi

28 Kasım 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 41 Sayı: 4

DOI

https://doi.org/10.7197/cmj.vi.643500

IZ

https://izlik.org/JA97JB35ZB

Kaynak Göster

RIS / Bibtex

AMA

1.Yücel B, Erdiş E. Definitive radiotherapy or chemoradiotherapy results and side effects in elderly bladder cancer patients. CMJ. 2019;41(4):703-711. doi:10.7197/cmj.vi.643500

Öz

Definitive radiotherapy or chemoradiotherapy results and side effects in elderly bladder cancer patients

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster