The effect of hypertension on survival in patients undergoing radiotherapy for brain metastasis

Eda Erdiş; Birsen Yücel

doi:10.7197/cmj.vi.643508

EN

The effect of hypertension on survival in patients undergoing radiotherapy for brain metastasis

Abstract

Objective: The prognosis of brain metastasis is very poor and the survival period is very short if the patient is not treated. The determination of prognostic factors is important in order to avoid invasive treatment interventions or unnecessary treatment in the management of patients with brain metastases. In this study, prognostic factors and the effect of hypertension on survival in patients with brain metastasis were investigated.

Method: In this study, the data of 463 patients diagnosed with brain metastasis, who were admitted to Cumhuriyet University Radiation Oncology department between 2007 and 2018, were retrospectively analyzed.

Results: The median age was 59 (18-82) years. There were 170 (37%) patients with comorbidity and 23% of these patients had hypertension in their medical history. With regard to primary cancer diagnoses, 271 (58%) patients had lung cancer, 91 (20%) breast, 31 (6%) gastrointestinal, 21 (5%) genitourinary, 13 (3%) gynecological, 11 (2%) unknown cancer and 25 (5%) had other types of cancer. At the time of diagnosis, 217 patients (47%) were in a metastatic stage. Median survival was 4 months (0-130 months); mean survival was 9.74 + 0.6 months; 1-year survival was 27% and 2-year survival was 13%. In univariate analysis, gender (p = .001), age (p < .001), hypertension (p = .018), primary diagnosis (p < .001), RPA (p < .001), number of lesions (p < .001), SRS (p < .001), metastatectomy (p < .001) and primary disease status (p = .002) were statistically significant. Multivariate analysis showed that hypertension (HR: 1.29, 95%; CI: 1.02-1.71; p = .027), age (HR: 1.39, 95%; CI: 1.08-1.77; p = .008), primary diagnosis (HR: 1.63, 95%; CI: 1.20 -2.23; p = .002), RPA (HR: 2.05, 95%; CI: 1.35-3.09; p = .001), metastatectomy (HR: 0.63, 95%; CI: 0.46-0.86; p = .004) and SRS (HR: 0.53, 95%; CI: 0.38-0.72, p < .001) were independent prognostic factors.

Conclusions: In this study, the presence of hypertension was as important in the prognosis of the disease as primary diagnosis, age, metastatectomy and SRS.

Keywords

Brain metastases,prognostic factors,survival,hypertension

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Eda Erdiş
0000-0003-3003-8643
Türkiye

Birsen Yücel
Türkiye

Yayımlanma Tarihi

31 Aralık 2019

Gönderilme Tarihi

6 Kasım 2019

Kabul Tarihi

28 Kasım 2019

Yayımlandığı Sayı

Yıl 2019 Cilt: 41 Sayı: 4

DOI

https://doi.org/10.7197/cmj.vi.643508

IZ

https://izlik.org/JA74BT69XJ

Kaynak Göster

RIS / Bibtex

AMA

1.Erdiş E, Yücel B. The effect of hypertension on survival in patients undergoing radiotherapy for brain metastasis. CMJ. 2019;41(4):712-720. doi:10.7197/cmj.vi.643508

Öz

The effect of hypertension on survival in patients undergoing radiotherapy for brain metastasis

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster