Zinc copper levels in patients with primary hyperparathyroidism

Filiz Alkan Baylan; Mehmet Bankir; Fettah Acıbucu; Metin Kılınç

doi:10.7197/cmj.884316

EN

Zinc copper levels in patients with primary hyperparathyroidism

Öz

Objective: Primary hyperparathyroidism (PHPTH) is an endocrine disorder with hypercalcemia due to increased parathormone (PTH) release. This study aims to investigate the relationship between PHPTH and serum zinc and copper levels.

Method: 35 patients diagnosed with PHPT and 30 healthy control cases were included in the study. Serum zinc and copper levels were measured in all patients.

Results: There was no difference between the groups in terms of age and gender. It was detected that serum Zn levels were significantly lower and serum Cu levels were higher in the PHPTH group compared to the control group (PHPTH Zn: 85.8±24.9 μ/dL, Cu: 81.2±13.8 μ/dL and Control Zn: 103.3±21.3 μ/dL, Cu: 72.6±13.3 μ/dL p = 0.004, p= 0.013, respectively). There was a weak positive correlation between serum Cu levels and PTH levels.

Conclusions: Serum zinc and copper levels should be considered in the clarification of the pathogenesis of PHPTH and in treatment planning.

Anahtar Kelimeler

Kaynakça

Referans1. Bilezikian JP, Bandeira L, Khan A, et al. Hyperparathyroidism. Lancet 2018;391:168e78.) (Bilezikian JP, Cusano NE, Khan AA, et al. Primary hyperparathyroidism. Nat Rev Dis Primers 2016;2:16033.
Referans2. Neer NM, Arnaud CD, Zanchetta JR, Price R,Gaich GA, Reginster JY, et al. Effect of Parathyroid hormone (1-34) on fractures and bone mineral dansity im postmenopausal women with osteoporosis. N Engl Med 2001;344(19):1434-41. doi: 10.1056/NEJM200105103441904.
Referans3. Seo HJ, Cho YE, Kim T, Shin HI, Kwun IS. Zinc may increase bone formation through stimulating cell proliferation, alkaline phosphatase activity and collogen synthesis in osteobalstic MC3T3-El cells. Nutr Res Pract 2010:4; 356-361.
Referans4. Kubıak K, Klımczak A, Dzıkı L, Modranka R, Malınowska K: Influence of copper (II) complex on the activity of selected oxidative enzymes. (In Polish) Pol Merkur Lekarski 28: 22-25, 2010.
Referans5. Lı Bb, Yu Sf: In vitro study of the effects of copper ion on osteoclastic resorption in various dental mineralized tissues. Zhoghua Kou Qiang Yi Xue Za Zhi 42: 110-113, 2007.
Referans6. Zofkova I, Davıs M, Blahos J. Trace Elements Have Beneficial, as Well as Detrimental Effects on Bone Homeostasis. Physiol. Res. 66: 391-402, 2017.
Referans7. Osteoporoz Ve Metabolik Kemik Hastalıkları Tanı Ve Tedavi Kılavuzu. Türkiye Endokrinoloji ve Metabolizma Derneği. ISBN: 978-605-66410-1-5. 13. Baskı: Mayıs 2018.
Referans8. Azza A El Tayeb, Nashwa A Abd El-Mottaleb, Ebtihal A Abdel Aziz. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res. 2009 May;128(2):128-34.

Referans9. O'Connor JP, Kanjilal D, Teitelbaum M, Lin SS, Cottrell JA. Zinc as a Therapeutic Agent in Bone Regeneration. Materials (Basel). 2020;13(10):2211. doi: 10.3390/ma13102211.
Referans10. Suzuki T, Kajita Y, Katsumata S, Matsuzaki H, Suzuki K (2015) Zinc deficiency increases serum concentrations of parathyroid hor- mone through a decrease in serum calcium and induces bone fra- gility in rats. J Nutr Sci Vitaminol (Tokyo) 61(5):382–390. https:// doi.org/10.3177/jnsv.61.382.
Referans11. El Tayeb AA, Abd El-Mottaleb NA, Abdel Aziz EA. Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children. Biol Trace Elem Res (2009) 128:128–134. DOI 10.1007/s12011-008-8265-x.
Referans12. Chen SM, Deng C, Iaio JF, HO LT (2005) Effects of parathyroid hormone on plasma zinc concentration in rat with chronic renal failure. Chin J Physiol 48(2):121–128.
Referans13. Simin Dashti-Khavidaki, Hossein Khalili, Seyedeh-Maryam Vahedi, Mahboob Lessan- Pezeshki. Serum Zinc Concentrations in Patients on Maintenance Hemodialysis and its Relationship with Anemia, Parathyroid Hormone Concentrations and Pruritus Severity. Saudi J Kidney Dis Transpl 2010;21(4):641-645.
Referans14. Malette LE, Henkin RI. Altered Copper and Zinc Metabolism in Primary Hyperparathyroidism. Am J Med Sci. 1976; 272(2):167-74.
Referans15. Deska M, Romuk E, Segiet OA, Buła G, Truchanowski W, Stolecka D, Birkner E, Gawrychowski Oxidative stress and angiogenesis in primary hyperparathyroidism. J. Eur Surg. 2017;49(3):118-126. doi: 10.1007/s10353-016-0457-6. Epub 2016 Dec 14.)

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Filiz Alkan Baylan
0000-0003-3117-7768
Türkiye

Mehmet Bankir ^*
0000-0003-3284-2838
Türkiye

Fettah Acıbucu
0000-0002-2252-2112
Türkiye

Metin Kılınç
0000-0002-1623-0201
Türkiye

Yayımlanma Tarihi

1 Temmuz 2021

Gönderilme Tarihi

21 Şubat 2021

Kabul Tarihi

29 Haziran 2021

Yayımlandığı Sayı

Yıl 2021 Cilt: 43 Sayı: 2

DOI

https://doi.org/10.7197/cmj.884316

IZ

https://izlik.org/JA55JK38JZ

Kaynak Göster

RIS / Bibtex

APA

Alkan Baylan, F., Bankir, M., Acıbucu, F., & Kılınç, M. (2021). Zinc copper levels in patients with primary hyperparathyroidism. Cumhuriyet Medical Journal, 43(2), 117-123. https://doi.org/10.7197/cmj.884316

AMA

1.Alkan Baylan F, Bankir M, Acıbucu F, Kılınç M. Zinc copper levels in patients with primary hyperparathyroidism. CMJ. 2021;43(2):117-123. doi:10.7197/cmj.884316

Chicago

Alkan Baylan, Filiz, Mehmet Bankir, Fettah Acıbucu, ve Metin Kılınç. 2021. “Zinc copper levels in patients with primary hyperparathyroidism”. Cumhuriyet Medical Journal 43 (2): 117-23. https://doi.org/10.7197/cmj.884316.

EndNote

Alkan Baylan F, Bankir M, Acıbucu F, Kılınç M (01 Temmuz 2021) Zinc copper levels in patients with primary hyperparathyroidism. Cumhuriyet Medical Journal 43 2 117–123.

IEEE

[1]F. Alkan Baylan, M. Bankir, F. Acıbucu, ve M. Kılınç, “Zinc copper levels in patients with primary hyperparathyroidism”, CMJ, c. 43, sy 2, ss. 117–123, Tem. 2021, doi: 10.7197/cmj.884316.

ISNAD

Alkan Baylan, Filiz - Bankir, Mehmet - Acıbucu, Fettah - Kılınç, Metin. “Zinc copper levels in patients with primary hyperparathyroidism”. Cumhuriyet Medical Journal 43/2 (01 Temmuz 2021): 117-123. https://doi.org/10.7197/cmj.884316.

JAMA

1.Alkan Baylan F, Bankir M, Acıbucu F, Kılınç M. Zinc copper levels in patients with primary hyperparathyroidism. CMJ. 2021;43:117–123.

MLA

Alkan Baylan, Filiz, vd. “Zinc copper levels in patients with primary hyperparathyroidism”. Cumhuriyet Medical Journal, c. 43, sy 2, Temmuz 2021, ss. 117-23, doi:10.7197/cmj.884316.

Vancouver

1.Filiz Alkan Baylan, Mehmet Bankir, Fettah Acıbucu, Metin Kılınç. Zinc copper levels in patients with primary hyperparathyroidism. CMJ. 01 Temmuz 2021;43(2):117-23. doi:10.7197/cmj.884316

Cited By

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

International Journal of Molecular Sciences

https://doi.org/10.3390/ijms23010044

Computational drug repurposing for primary hyperparathyroidism

Molecular and Cellular Endocrinology

https://doi.org/10.1016/j.mce.2024.112159