Araştırma Makalesi
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Yıl 2022, , 362 - 369, 31.12.2022
https://doi.org/10.7197/cmj.1164858

Öz

Kaynakça

  • 1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382:727-733.
  • 2. Golob JL, Lugogo N, Lauring AS, Lok AS. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight. 2021.
  • 3. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25.
  • 4. Arevalo-Rodriguez I, Buitrago-Garcia D, Simancas-Racines D, et al. False-negative results of initial RT-PCR assays for COVID-19: A systematic review. PLoS One. 2020;15:e0242958.
  • 5. Green DA, Zucker J, Westblade LF, et al. Clinical Performance of SARS-CoV-2 Molecular Tests. J Clin Microbiol. 2020;58.
  • 6. Kanji JN, Zelyas N, MacDonald C, et al. False negative rate of COVID-19 PCR testing: a discordant testing analysis. Virol J. 2021;18:13.
  • 7. Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30:4381-4389.
  • 8. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology. 2020;296:E115-E117.
  • 9. Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296:E32-E40.
  • 10. Khatami F, Saatchi M, Zadeh SST, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Sci Rep. 2020;10:22402.
  • 11. Islam N, Salameh JP, Leeflang MM, et al. Thoracic imaging tests for the diagnosis of COVID-19. Cochrane Database Syst Rev. 2020;11:CD013639.
  • 12. Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219-227.
  • 13. Kanne JP, Bai H, Bernheim A, et al. COVID-19 Imaging: What We Know Now and What Remains Unknown. Radiology. 2021:204522.
  • 14. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672-675.
  • 15. Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Ann Intern Med. 2020;173:262-267.
  • 16. Zhang Z, Bi Q, Fang S, et al. Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study. Lancet Microbe. 2021;2:e79-e87.
  • 17. Kwee TC, Kwee RM. Chest CT in COVID-19: What the Radiologist Needs to Know. Radiographics. 2020;40:1848-1865.
  • 18. Ravikanth R. Diagnostic accuracy and false-positive rate of chest CT as compared to RT-PCR in coronavirus disease 2019 (COVID-19) pneumonia: A prospective cohort of 612 cases from India and review of literature. Indian J Radiol Imaging. 2021;31:S161-S169.
  • 19. Waller JV, Kaur P, Tucker A, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. AJR Am J Roentgenol. 2020;215:834-838.
  • 20. Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-19) on chest CT: spectrum of CT and clinical features. Insights Imaging. 2021;12:12.

Can Chest CT be The First-Line Diagnostic Test in COVID-19? A Cross-Sectional Study

Yıl 2022, , 362 - 369, 31.12.2022
https://doi.org/10.7197/cmj.1164858

Öz

Background/aim: Early in the COVID-19 pandemic, chest computerized tomography (CCT) was shown to be more sensitive than real-time reverse transcription polymerase chain Reaction (rRT-PCR) in detecting the disease, especially in regions with high disease prevalence. In this study, we aimed to determine the sensitivity and specificity of chest CT in the diagnosis of COVID-19.
Materials and Methods: Between 17 March, 2020 and 25 April, 2020, 2170 patients who were admitted to the hospital for any reason and underwent chest CT scanning were retrospectively analyzed. Patients with a pre-diagnosis of COVID-19 and a positive rRT-PCR test, two consecutive negative rRT-PCR tests, or with a first negative rRT-PCR test and a positive follow-up rRT-PCR test were included. The day of the rRT-PCR test for these patients was counted as day “0,” and 200 patients whose CCT was performed within +/- three days were included in the study.
Results: Of the 200 patients included in the study, 118 were rRT-PCR-positive, and 82 were rRT-PCR-negative. Of the 118 patients with positive rRT-PCR results, 62/118 (52.5%) had positive CCT scans. With the rRT-PCR results as the reference, the sensitivity, specificity, and accuracy of CCT in indicating COVID-19 infection were 52.5% (95% CI 43–61%), 67% (95% CI 56–77%), and 58.5% (95% CI 51-65%), respectively. The negative predictive value of CCT in diagnosing COVID-19 was greater for women than for men (p = 0.01).
Conclusions: In regions where the prevalence of COVID-19 is not high, the use of CCT in the diagnosis of the disease is not an alternative to the rRT-PCR test due to its low sensitivity.

Kaynakça

  • 1. Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020;382:727-733.
  • 2. Golob JL, Lugogo N, Lauring AS, Lok AS. SARS-CoV-2 vaccines: a triumph of science and collaboration. JCI Insight. 2021.
  • 3. Corman VM, Landt O, Kaiser M, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25.
  • 4. Arevalo-Rodriguez I, Buitrago-Garcia D, Simancas-Racines D, et al. False-negative results of initial RT-PCR assays for COVID-19: A systematic review. PLoS One. 2020;15:e0242958.
  • 5. Green DA, Zucker J, Westblade LF, et al. Clinical Performance of SARS-CoV-2 Molecular Tests. J Clin Microbiol. 2020;58.
  • 6. Kanji JN, Zelyas N, MacDonald C, et al. False negative rate of COVID-19 PCR testing: a discordant testing analysis. Virol J. 2021;18:13.
  • 7. Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review. Eur Radiol. 2020;30:4381-4389.
  • 8. Fang Y, Zhang H, Xie J, et al. Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR. Radiology. 2020;296:E115-E117.
  • 9. Ai T, Yang Z, Hou H, et al. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. Radiology. 2020;296:E32-E40.
  • 10. Khatami F, Saatchi M, Zadeh SST, et al. A meta-analysis of accuracy and sensitivity of chest CT and RT-PCR in COVID-19 diagnosis. Sci Rep. 2020;10:22402.
  • 11. Islam N, Salameh JP, Leeflang MM, et al. Thoracic imaging tests for the diagnosis of COVID-19. Cochrane Database Syst Rev. 2020;11:CD013639.
  • 12. Simpson S, Kay FU, Abbara S, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219-227.
  • 13. Kanne JP, Bai H, Bernheim A, et al. COVID-19 Imaging: What We Know Now and What Remains Unknown. Radiology. 2021:204522.
  • 14. He X, Lau EHY, Wu P, et al. Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020;26:672-675.
  • 15. Kucirka LM, Lauer SA, Laeyendecker O, Boon D, Lessler J. Variation in False-Negative Rate of Reverse Transcriptase Polymerase Chain Reaction-Based SARS-CoV-2 Tests by Time Since Exposure. Ann Intern Med. 2020;173:262-267.
  • 16. Zhang Z, Bi Q, Fang S, et al. Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study. Lancet Microbe. 2021;2:e79-e87.
  • 17. Kwee TC, Kwee RM. Chest CT in COVID-19: What the Radiologist Needs to Know. Radiographics. 2020;40:1848-1865.
  • 18. Ravikanth R. Diagnostic accuracy and false-positive rate of chest CT as compared to RT-PCR in coronavirus disease 2019 (COVID-19) pneumonia: A prospective cohort of 612 cases from India and review of literature. Indian J Radiol Imaging. 2021;31:S161-S169.
  • 19. Waller JV, Kaur P, Tucker A, et al. Diagnostic Tools for Coronavirus Disease (COVID-19): Comparing CT and RT-PCR Viral Nucleic Acid Testing. AJR Am J Roentgenol. 2020;215:834-838.
  • 20. Elmokadem AH, Batouty NM, Bayoumi D, et al. Mimickers of novel coronavirus disease 2019 (COVID-19) on chest CT: spectrum of CT and clinical features. Insights Imaging. 2021;12:12.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Dahili Tıp Bilimleri Araştırma Yazıları
Yazarlar

Halil Çaylak 0000-0001-8089-4822

Dilara Atasoy 0000-0001-7924-1752

Nazim Çetinkaya 0000-0001-9596-9057

İsmet Can 0000-0002-5188-944X

Rağıp Sarıismailoğlu 0000-0002-1859-6100

Mehmet Atalar 0000-0003-3076-8072

Yayımlanma Tarihi 31 Aralık 2022
Kabul Tarihi 21 Aralık 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

AMA Çaylak H, Atasoy D, Çetinkaya N, Can İ, Sarıismailoğlu R, Atalar M. Can Chest CT be The First-Line Diagnostic Test in COVID-19? A Cross-Sectional Study. CMJ. Aralık 2022;44(4):362-369. doi:10.7197/cmj.1164858