Araştırma Makalesi
BibTex RIS Kaynak Göster

Analyzing The Relationship Between Systemic Inflammatory Index, Neutrophil Lymphocyte Ratios And Covid-19 Infection

Yıl 2023, , 67 - 73, 30.06.2023
https://doi.org/10.7197/cmj.1238446

Öz

Introduction: There are important parameters in understanding the severity of COVID-19 infection. We aimed to observe the role of systemic inflammatory index and neutrophil lymphocyte ratios in Covid-19 infections and the changes seen during the infection process.
Method: This retrospective single-center study was conducted between April 2020 and May 2020. Clinical, demographic and laboratory data of patients with COVID-19 were analyzed. All COVID-19 case confirmation made with reverse transcription polymerase chain reaction. Neutrophil/lymphocyte ratio and SII change and relationship were examined.
Results: 140 patients were included in our study and 50 of them were female. There was no statistically significant difference in SII according to gender (p>0.05) but there was a difference in SII between age categories (p=0.009). A statistically significant difference was found (p=0.003) regardless of the presence of comorbidities. Tobacco users had a significantly lower SII (p=0.028). A statistically significant difference was found between SII and Covid Severity Index (p=0.020). A statistically significant difference was found in the SII values of those receiving favipiravir treatment and those receiving hydroxychloroquine treatment (p<0.001). A statistically significant difference was found between those who received treatment in the outpatient clinic and those who received treatment in the intensive care unit (p=0.043). A statistically significant difference in the SII values was found between the patients who died and those who survived (p= 0.009).

Conclusion: The Systemic Inflammatory Index is a parameter that can be used for the Covid-19 patient follow-up and estimating mortality.

Destekleyen Kurum

yok

Proje Numarası

yok

Teşekkür

-

Kaynakça

  • 1. Fois AG, Paliogiannis P. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020;4;25(23):5725.
  • 2. World Health Organization. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 106, https://www.who.int/emergencies/diseases/ novel-coronavirus-2019/situation-reports (2021)
  • 3. Süzer NE, Sirkeci EE, Sirkeci O. Are basic inflammation markers sufficient for predicting Covid 19 infection, Acta Medica Mediterranea. 2021;37(2):1127-1131.
  • 4. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
  • 5. Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol. Infect. 2020;148:e139. 6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–1242.
  • 7. Wang D, Hu B, Hu C et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;17;323(11):1061-1069.
  • 8. Zhou F, Yu T, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062.
  • 9. Usul E, San I, Bekgoz B, Sahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark. Med. 2020;14:1207–1215.
  • 10. Paliogiannis P, Fois AG, Sotgia S et al. The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: A systematic review and meta-analysis. Eur. J. Clin. Investig. 2018;48:e12984.
  • 11. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91: 181-4.

Sistemik İnflamatuar İndeks Ve Nötrofil Lenfosit Oranlarının Covid-19 Enfeksiyonu İle İlişkilerinin Analizi

Yıl 2023, , 67 - 73, 30.06.2023
https://doi.org/10.7197/cmj.1238446

Öz

Giriş: COVID-19 enfeksiyonunun ciddiyetini anlamada önemli parametreler bulunmaktadır. Çalışmamızda amacımız Sistemik inflamatuar index (SII) ve nötrofil lenfosit oranlarının Covid-19 Enfeksiyonu ve bu enfeksiyon sürecindeki değişim ile ilişkilerini ortaya koymaktır.
Method: Nisan 2020-Mayıs 2020 tarihleri arasında yapılan retrospektif tek merkezli bir çalışmadır. COVID-19 hastalığı tüm vakalarda ters transkripsiyon polimeraz zincir reaksiyonu ile doğrulanan hastaların demografik, klinik ve laboratuvar verileri incelendi. Nötrofil/lenfosit oranı ve SII değişimi ve ilişkisi incelendi.

Bulgular: Çalışmamızda 50’si kadın toplam 140 hasta bulunmaktadır. İstatistiksel olarak Cinsiyetlere göre SII ‘de farklılık bulunmaz iken (p>0.05), yaş katagorileri arasında SII ‘de anlamlı farklılık saptanmıştır (p=0,009). Komorbidite olup olmaması durumunda, SII ‘de istatistiksel anlamlı farklılıklar saptandı (p=0,003). Tütün kullananların SII nin daha az olduğu ve bunun anlamlı olduğu bulundu (p=0.028). SII ile Covid Severity İndexin, karşılaştırılmasında; gruplar arası istatistiksel anlamlı farklılık bulundu (p=0.020). Favipravir tedavisi alanlar ile hidroksiklorokin tedavisi alanların SII değerlerinde istatistiksel anlamlı farklılık bulundu (p<0.001). Klinikte tedavi alanlar ile yoğun bakımda tedavi alanlar arasında istatistiksel olarak anlamlı farklılık bulundu (p=0,043) Hastalardan ölenlerin ve yaşayanların SII’lerinin gruplar arasında istatistiksel olarak anlamlı farklılık bulundu (p= 0.009).
Sonuç: Sistemik İnflamatuar İndeks, Covid-19 hastalarının takibinde ve mortalite tahminlerinde kullanılabilir bir parametredir.

Proje Numarası

yok

Kaynakça

  • 1. Fois AG, Paliogiannis P. The Systemic Inflammation Index on Admission Predicts In-Hospital Mortality in COVID-19 Patients. Molecules. 2020;4;25(23):5725.
  • 2. World Health Organization. World Health Organization. Coronavirus disease 2019 (COVID-19) Situation Report – 106, https://www.who.int/emergencies/diseases/ novel-coronavirus-2019/situation-reports (2021)
  • 3. Süzer NE, Sirkeci EE, Sirkeci O. Are basic inflammation markers sufficient for predicting Covid 19 infection, Acta Medica Mediterranea. 2021;37(2):1127-1131.
  • 4. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506.
  • 5. Kong M, Zhang H, Cao X, Mao X, Lu Z. Higher level of neutrophil-to-lymphocyte is associated with severe COVID-19. Epidemiol. Infect. 2020;148:e139. 6. Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323:1239–1242.
  • 7. Wang D, Hu B, Hu C et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;17;323(11):1061-1069.
  • 8. Zhou F, Yu T, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020;395:1054–1062.
  • 9. Usul E, San I, Bekgoz B, Sahin A. Role of hematological parameters in COVID-19 patients in the emergency room. Biomark. Med. 2020;14:1207–1215.
  • 10. Paliogiannis P, Fois AG, Sotgia S et al. The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: A systematic review and meta-analysis. Eur. J. Clin. Investig. 2018;48:e12984.
  • 11. Walsh SR, Cook EJ, Goulder F, Justin TA, Keeling NJ. Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer. J Surg Oncol 2005; 91: 181-4.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Cerrahi Tıp Bilimleri Araştırma Yazıları
Yazarlar

Hayri Canbaz 0000-0001-6989-7854

Neslihan Ergün Süzer 0000-0003-4839-8110

Özgür Sirkeci 0000-0001-9048-5096

Emel Erkuş Sirkeci 0000-0003-2743-7619

Proje Numarası yok
Erken Görünüm Tarihi 30 Haziran 2023
Yayımlanma Tarihi 30 Haziran 2023
Kabul Tarihi 9 Haziran 2023
Yayımlandığı Sayı Yıl 2023

Kaynak Göster

AMA Canbaz H, Ergün Süzer N, Sirkeci Ö, Erkuş Sirkeci E. Analyzing The Relationship Between Systemic Inflammatory Index, Neutrophil Lymphocyte Ratios And Covid-19 Infection. CMJ. Haziran 2023;45(2):67-73. doi:10.7197/cmj.1238446