Araştırma Makalesi
Yıl 2019,
, 64 - 68, 28.03.2019
Öz
Objective: Osteopontin (OPN) is an extracellular matrix protein which has been
associated with immune response and tissue repair in the central nervous
system.
We set out to investigate the OPN values and its association with
clinical features in patients with ischemic stroke.
Method: Serum OPN values of 35 patients with ischemic stroke were compared
with 35 controls at the admission and at the seventh day following the event. Correlations
between OPN levels and disease specific features were also calculated.
Results: Serum OPN
values were not significantly different between patients and controls at
baseline. In patients, an increase in OPN values was detected at follow-up
which was significantly higher than the controls. The OPN levels were not
correlated with infarct size or disease severity.
Conclusions: Serum OPN levels increase not in the hyperacute/acute phase of the stroke
but in the subacute phase. No association with disease severity or lesion
volume is detected.
Anahtar Kelimeler
Kaynakça
- 1. Mazzali M, Kipari T, Ophascharoensuk V, Wesson JA, Johnson R, Hughes J. Osteopontin--a molecule for all seasons. QJM [Internet]. 2002 Jan [cited 2018 Dec 7];95(1):3–13.
- 2. Wang KX, Denhardt DT. Osteopontin: Role in immune regulation and stress responses. Cytokine Growth Factor Rev [Internet]. 2008 Oct [cited 2018 Dec 7];19(5–6):333–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18952487
- 3. Ladwig A, Rogall R, Hucklenbroich J, Willuweit A, Schoeneck M, Langen K-J, et al. Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke. J Neuroimmune Pharmacol [Internet]. 2018 Nov 28 [cited 2018 Dec 7]; Available from: http://link.springer.com/10.1007/s11481-018-9826-1
- 4. Schroeter M, Zickler P, Denhardt DT, Hartung H-P, Jander S. Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice. Brain [Internet]. 2006 Jun 13 [cited 2018 Dec 7];129(Pt 6):1426–37. Available from: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl094
- 5. Gliem M, Krammes K, Liaw L, van Rooijen N, Hartung H-P, Jander S. Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia [Internet]. 2015 Dec [cited 2018 Dec 7];63(12):2198–207. Available from: http://doi.wiley.com/10.1002/glia.22885
- 6. Wang X, Louden C, Yue TL, Ellison JA, Barone FC, Solleveld HA, et al. Delayed expression of osteopontin after focal stroke in the rat. J Neurosci [Internet]. 1998 Mar 15 [cited 2018 Dec 7];18(6):2075–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9482794
- 7. Ellison JA, Velier JJ, Spera P, Jonak ZL, Wang X, Barone FC, et al. Osteopontin and its integrin receptor alpha(v)beta3 are upregulated during formation of the glial scar after focal stroke. Stroke [Internet]. 1998 Aug [cited 2018 Dec 7];29(8):1698–706; discussion 1707. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9707214
- 8. Ladwig A, Walter HL, Hucklenbroich J, Willuweit A, Langen K-J, Fink GR, et al. Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia. Mediators Inflamm [Internet]. 2017 [cited 2018 Dec 7];2017:7189421. Available from: https://www.hindawi.com/journals/mi/2017/7189421/
- 9. Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, et al. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab [Internet]. 2005 Feb 28 [cited 2018 Dec 7];25(2):217–25. Available from: http://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600022
- 10. Doyle KP, Yang T, Lessov NS, Ciesielski TM, Stevens SL, Simon RP, et al. Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab [Internet]. 2008 Jun 26 [cited 2018 Dec 7];28(6):1235–48. Available from: http://journals.sagepub.com/doi/10.1038/jcbfm.2008.17
- 11. Wolak T, Sion-Vardi N, Novack V, Greenberg G, Szendro G, Tarnovscki T, et al. N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients. Am J Hypertens [Internet]. 2013 Mar 1 [cited 2018 Dec 7];26(3):326–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23382482
- 12. Ozaki S, Kurata M, Kumon Y, Matsumoto S, Tagawa M, Watanabe H, et al. Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke. Hypertens Res [Internet]. 2017 Jan 25 [cited 2018 Dec 7];40(1):61–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27558929
- 13. Hedtjärn M, Mallard C, Hagberg H. Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia. J Cereb Blood Flow Metab [Internet]. 2004 Dec 31 [cited 2018 Dec 7];24(12):1333–51. Available from: http://journals.sagepub.com/doi/10.1097/01.WCB.0000141559.17620.36
- 14. Carbone F, Rigamonti F, Burger F, Roth A, Bertolotto M, Spinella G, et al. Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis. Int J Cardiol [Internet]. 2018 Mar 15 [cited 2018 Dec 7];255:195–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29317141
Yıl 2019,
, 64 - 68, 28.03.2019
Öz
Amaç: Osteopontin merkezi sinir sisteminde immün yanıt ve doku tamiri ile ilişkili bir ekstraselüler matrix proteinidir. İskemik inmeli hastalarda osteopontin değerlerini ve bu değerlerin klinik bulgular ile olan ilişkisini tespit etmektir.
Yöntem: Çalışma kapsamında 35 hastanın inmenin ilk günü ve yedinci günü serum osteopontin seviyeleri
35 kontrol ile karşılastırıldı. Ayrıca
osteopontin değerleri ve hastalık özellikleri arasındaki korelasyon incelendi.
Bulgular:
İnmenin ilk günü ölçülen osteopontin değerlerinde hastalar ve kontroller arasında anlamlı fark bulunmadı. Hastaların yedinci gün değerleri ise kontrollere oranla anlamlı derecede yüksekti. Osteopontin degerleri infarkt
büyüklüğü ya da hastalık derecesi ile anlamlı korelasyon göstermedi.
Sonuç:
Serum osteopontin
değerleri inmenin hiperakut/akut evresinden
cok subakut döneminde yükselmektedir. Osteopontin yüksekliği, infarkt boyutu veya klinik durumdan bağımsız olabilir.
Anahtar Kelimeler
Kaynakça
- 1. Mazzali M, Kipari T, Ophascharoensuk V, Wesson JA, Johnson R, Hughes J. Osteopontin--a molecule for all seasons. QJM [Internet]. 2002 Jan [cited 2018 Dec 7];95(1):3–13.
- 2. Wang KX, Denhardt DT. Osteopontin: Role in immune regulation and stress responses. Cytokine Growth Factor Rev [Internet]. 2008 Oct [cited 2018 Dec 7];19(5–6):333–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18952487
- 3. Ladwig A, Rogall R, Hucklenbroich J, Willuweit A, Schoeneck M, Langen K-J, et al. Osteopontin Attenuates Secondary Neurodegeneration in the Thalamus after Experimental Stroke. J Neuroimmune Pharmacol [Internet]. 2018 Nov 28 [cited 2018 Dec 7]; Available from: http://link.springer.com/10.1007/s11481-018-9826-1
- 4. Schroeter M, Zickler P, Denhardt DT, Hartung H-P, Jander S. Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice. Brain [Internet]. 2006 Jun 13 [cited 2018 Dec 7];129(Pt 6):1426–37. Available from: https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awl094
- 5. Gliem M, Krammes K, Liaw L, van Rooijen N, Hartung H-P, Jander S. Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke. Glia [Internet]. 2015 Dec [cited 2018 Dec 7];63(12):2198–207. Available from: http://doi.wiley.com/10.1002/glia.22885
- 6. Wang X, Louden C, Yue TL, Ellison JA, Barone FC, Solleveld HA, et al. Delayed expression of osteopontin after focal stroke in the rat. J Neurosci [Internet]. 1998 Mar 15 [cited 2018 Dec 7];18(6):2075–83. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9482794
- 7. Ellison JA, Velier JJ, Spera P, Jonak ZL, Wang X, Barone FC, et al. Osteopontin and its integrin receptor alpha(v)beta3 are upregulated during formation of the glial scar after focal stroke. Stroke [Internet]. 1998 Aug [cited 2018 Dec 7];29(8):1698–706; discussion 1707. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9707214
- 8. Ladwig A, Walter HL, Hucklenbroich J, Willuweit A, Langen K-J, Fink GR, et al. Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia. Mediators Inflamm [Internet]. 2017 [cited 2018 Dec 7];2017:7189421. Available from: https://www.hindawi.com/journals/mi/2017/7189421/
- 9. Meller R, Stevens SL, Minami M, Cameron JA, King S, Rosenzweig H, et al. Neuroprotection by osteopontin in stroke. J Cereb Blood Flow Metab [Internet]. 2005 Feb 28 [cited 2018 Dec 7];25(2):217–25. Available from: http://journals.sagepub.com/doi/10.1038/sj.jcbfm.9600022
- 10. Doyle KP, Yang T, Lessov NS, Ciesielski TM, Stevens SL, Simon RP, et al. Nasal administration of osteopontin peptide mimetics confers neuroprotection in stroke. J Cereb Blood Flow Metab [Internet]. 2008 Jun 26 [cited 2018 Dec 7];28(6):1235–48. Available from: http://journals.sagepub.com/doi/10.1038/jcbfm.2008.17
- 11. Wolak T, Sion-Vardi N, Novack V, Greenberg G, Szendro G, Tarnovscki T, et al. N-Terminal Rather Than Full-Length Osteopontin or Its C-Terminal Fragment Is Associated With Carotid-Plaque Inflammation in Hypertensive Patients. Am J Hypertens [Internet]. 2013 Mar 1 [cited 2018 Dec 7];26(3):326–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23382482
- 12. Ozaki S, Kurata M, Kumon Y, Matsumoto S, Tagawa M, Watanabe H, et al. Plasma thrombin-cleaved osteopontin as a potential biomarker of acute atherothrombotic ischemic stroke. Hypertens Res [Internet]. 2017 Jan 25 [cited 2018 Dec 7];40(1):61–6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27558929
- 13. Hedtjärn M, Mallard C, Hagberg H. Inflammatory gene profiling in the developing mouse brain after hypoxia-ischemia. J Cereb Blood Flow Metab [Internet]. 2004 Dec 31 [cited 2018 Dec 7];24(12):1333–51. Available from: http://journals.sagepub.com/doi/10.1097/01.WCB.0000141559.17620.36
- 14. Carbone F, Rigamonti F, Burger F, Roth A, Bertolotto M, Spinella G, et al. Serum levels of osteopontin predict major adverse cardiovascular events in patients with severe carotid artery stenosis. Int J Cardiol [Internet]. 2018 Mar 15 [cited 2018 Dec 7];255:195–9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29317141
Toplam 14 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Dahili Tıp Bilimleri Araştırma Yazıları |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Mart 2019 |
| Kabul Tarihi | 26 Mart 2019 |
| Yayımlandığı Sayı | Yıl 2019 |